日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multi-laboratory comparisons of manual patch clamp hERG data generated using standardized protocols and following ICH S7B Q&A 2.1 best practices

使用标准化方案并遵循ICH S7B问答2.1最佳实践,对手动膜片钳hERG数据进行多实验室比较。

Alvarez Baron, Claudia; Zhao, Jun; Yu, Huimei; Ren, Ming; Thiebaud, Nicolas; Guo, Donglin; Vegesna, Giri; Hsiao, Cheng-Hui; DePalma, Ryan; Mistry, Sabyasachy; Tariq, Isra; Roni, Md Shadiqur Rashid; Ismaiel, Omnia A; Matta, Murali K; Patel, Vikram; Mashaee, Manni; Vicente, Jose; Johannesen, Lars; Sheng, Jiansong; Hebeisen, Simon; Kramer, James; Bruening-Wright, Andrew; Nakano, Koji; Matsukawa, Hiroshi; Pierson, Jennifer Beck; Wu, Wendy W

Reassessing the Conduct of Patch Clamp Cardiac Ion Channel Assays to Improve Nonclinical Data Translation to Clinical ECG Changes and Proarrythmia Risk.

重新评估膜片钳心脏离子通道检测方法,以改进非临床数据向临床心电图变化和致心律失常风险的转化。

Alvarez Baron Claudia, Zhao Jun, Guo Donglin, Mistry Sabyasachy, De Palma Ryan, Ismaiel Omnia A, Wu Wendy W

Integrating drug effects on individual cardiac ionic currents and cardiac action potentials to understand nonclinical translation to clinical ECG changes

整合药物对个体心脏离子电流和心脏动作电位的影响,以了解非临床结果如何转化为临床心电图变化。

Johannesen, Lars; Abi-Gerges, Najah; Sweat, Katrina; Roup, Ana; Page, Guy; Baron, Claudia Alvarez; Yu, Huimei; Wu, Wendy W

Metabolic and transcriptional activities underlie stationary-phase Pseudomonas aeruginosa sensitivity to Levofloxacin

代谢和转录活性是稳定期铜绿假单胞菌对左氧氟沙星敏感性的基础

Patricia J Hare, Juliet R Gonzalez, Ryan M Quelle, Yi I Wu, Wendy W K Mok

New science, drug regulation, and emergent public health issues: The work of FDA's division of applied regulatory science

新科学、药物监管和新兴公共卫生问题:FDA应用监管科学部门的工作

Chiu, Kimberly; Racz, Rebecca; Burkhart, Keith; Florian, Jeffry; Ford, Kevin; Iveth Garcia, M; Geiger, Robert M; Howard, Kristina E; Hyland, Paula L; Ismaiel, Omnia A; Kruhlak, Naomi L; Li, Zhihua; Matta, Murali K; Prentice, Kristin W; Shah, Aanchal; Stavitskaya, Lidiya; Volpe, Donna A; Weaver, James L; Wu, Wendy W; Rouse, Rodney; Strauss, David G

Translational Models and Tools to Reduce Clinical Trials and Improve Regulatory Decision Making for QTc and Proarrhythmia Risk (ICH E14/S7B Updates)

减少临床试验并改进 QTc 间期和致心律失常风险监管决策的转化模型和工具(ICH E14/S7B 更新)

Strauss, David G; Wu, Wendy W; Li, Zhihua; Koerner, John; Garnett, Christine

Corrigendum to "A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm" [Toxicology and Applied Pharmacology volume 394C (2020) 114961]

对“评估 hERG 阻滞效力的系统策略及其在新的心脏安全范式中的意义”的更正[毒理学和应用药理学卷 394C (2020) 114961]

Ridder, Bradley J; Leishman, Derek J; Bridgland-Taylor, Matthew; Samieegohar, Mohammadreza; Han, Xiaomei; Wu, Wendy W; Randolph, Aaron; Tran, Phu; Sheng, Jiansong; Danker, Timm; Lindqvist, Anders; Konrad, Daniel; Hebeisen, Simon; Polonchuk, Liudmila; Gissinger, Evgenia; Renganathan, Muthukrishnan; Koci, Bryan; Wei, Haiyang; Fan, Jingsong; Levesque, Paul; Kwagh, Jae; Imredy, John; Zhai, Jin; Rogers, Marc; Humphries, Edward; Kirby, Robert; Stoelzle-Feix, Sonja; Brinkwirth, Nina; Rotordam, Maria Giustina; Becker, Nadine; Friis, Søren; Rapedius, Markus; Goetze, Tom A; Strassmaier, Tim; Okeyo, George; Kramer, James; Kuryshev, Yuri; Wu, Caiyun; Himmel, Herbert; Mirams, Gary R; Strauss, David G; Bardenet, Remi; Li, Zhihua

A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm.

评估 hERG 阻滞效力的系统策略及其在新心脏安全范式中的意义

Ridder Bradley J, Leishman Derek J, Bridgland-Taylor Matthew, Samieegohar Mohammadreza, Han Xiaomei, Wu Wendy W, Randolph Aaron, Tran Phu, Sheng Jiansong, Danker Timm, Lindqvist Anders, Konrad Daniel, Hebeisen Simon, Polonchuk Liudmila, Gissinger Evgenia, Renganathan Muthukrishnan, Koci Bryan, Wei Haiyang, Fan Jingsong, Levesque Paul, Kwagh Jae, Imredy John, Zhai Jin, Rogers Marc, Humphries Edward, Kirby Robert, Stoelzle-Feix Sonja, Brinkwirth Nina, Rotordam Maria Giustina, Becker Nadine, Friis Søren, Rapedius Markus, Goetze Tom A, Strassmaier Tim, Okeyo George, Kramer James, Kuryshev Yuri, Wu Caiyun, Himmel Herbert, Mirams Gary R, Strauss David G, Bardenet Rémi, Li Zhihua

Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative

在CiPA计划下评估用于预测心律失常风险的计算机模拟机制模型

Li, Zhihua; Ridder, Bradley J; Han, Xiaomei; Wu, Wendy W; Sheng, Jiansong; Tran, Phu N; Wu, Min; Randolph, Aaron; Johnstone, Ross H; Mirams, Gary R; Kuryshev, Yuri; Kramer, James; Wu, Caiyun; Crumb, William J Jr; Strauss, David G

Functional changes in hippocampal synaptic signaling in offspring survivors of a mouse model of intrauterine inflammation

子宫内炎症小鼠模型后代海马突触信号传导的功能变化

Kelley, Melissa H; Wu, Wendy W; Lei, Jun; McLane, Michael; Xie, Han; Hart, Kyle D; Pereira, Leonardo; Burd, Irina; Maylie, James