日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

TREM2表达水平对小胶质细胞状态、代谢能力和TREM2激动剂的疗效至关重要。

Feiten, Astrid F; Dahm, Kilian; Schlepckow, Kai; van Lengerich, Bettina; Suh, Jung H; Reifschneider, Anika; Wefers, Benedikt; Bartos, Laura M; Wind-Mark, Karin; de Weerd, Lis; Ulas, Thomas; De-Domenico, Elena; Grundschöttel, Pia; Paulusch, Stefan; Tast, Benjamin; Honda, Tamisa; Müller, Stephan A; Becker, Matthias; Khalin, Igor; Ricci, Alessio; Liesz, Arthur; Brunner, Bettina; Krenner, Claudia; Buschmann, Katrin; Nuscher, Brigitte; Spieth, Lena; Junker, Niklas; Berghoff, Stefan A; Davis, Sonnet S; Neher, Jonas J; Wurst, Wolfgang; Plesnila, Nikolaus; Lewcock, Joseph W; Simons, Mikael; Lichtenthaler, Stefan F; Di Paolo, Gilbert; Brendel, Matthias; Capell, Anja; Monroe, Kathryn M; Schultze, Joachim L; Haass, Christian

VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and α-synuclein pathology in DJ-1-linked Parkinson's neurons.

VMAT2 功能障碍会损害囊泡多巴胺的摄取,从而导致 DJ-1 相关的帕金森神经元中多巴胺的氧化和 α-突触核蛋白病理。

Heger Leonie M, Gubinelli Francesco, Huber Andreas J, Cardona-Alberich Aida, Rovere Matteo, Matti Ulf, Müller Stephan A, Nagaraja Sankarshana R, Jaschkowitz Lena, Schifferer Martina, Wurst Wolfgang, Lichtenthaler Stefan F, Behrends Christian, Sambandan Sivakumar, Burbulla Lena F

Cobalt-based metallo-mesoionic carbene gold complexes with antiproliferative effects

具有抗增殖作用的钴基金属介离子卡宾金配合物

Menia, D; Neururer, F R; Wurst, K; Lippmann, P; Esarev, I V; Seidl, M; Ott, I; Podewitz, M; Hohloch, S; Bildstein, B

Allenylidene Phosphonium Ion: An Isoelectronic Phosphorus Analogue of [3]Cumulene

烯丙基膦鎓离子:[3]累积烯的等电子磷类似物

Torres, Lucas C; Löwe, Pawel; Bhattacharjee, Avik; Röthel, Maike B; Seidl, Michael; LeBlanc, Jesse; Wurst, Klaus; Dielmann, Fabian; Caputo, Christopher B

RNase T2 restricts TLR13-mediated autoinflammation in vivo

RNase T2 在体内抑制 TLR13 介导的自身炎症

Carlos Gomez-Diaz ,Wilhelm Greulich ,Benedikt Wefers ,Meiyue Wang ,Silvia Bolsega ,Maike Effern ,Daniel P Varga ,Zhe Han ,Minyi Chen ,Marleen Bérouti ,Natascia Leonardi ,Ulrike Schillinger ,Bernhard Holzmann ,Arthur Liesz ,Axel Roers ,Michael Hölzel ,Marijana Basic ,Wolfgang Wurst ,Veit Hornung

A bipolar disorder-associated missense variant alters adenylyl cyclase 2 activity and promotes mania-like behavior

与双相情感障碍相关的错义变异会改变腺苷酸环化酶 2 的活性,并促进躁狂样行为。

Sen, Paromita; Ortiz, Oskar; Brivio, Elena; Menegaz, Danusa; Sotillos Elliott, Laura; Du, Ying; Ries, Clemens; Chen, Alon; Wurst, Wolfgang; Lopez, Juan Pablo; Eder, Matthias; Deussing, Jan M

Neuropathy-associated Tecpr2 mutation knock-in mice reveal endolysosomal loss of function phenotypes in neurons and microglia

神经病变相关的Tecpr2突变敲入小鼠揭示了神经元和小胶质细胞中内溶酶体功能丧失的表型。

Bhattacharya, Debjani; da Silva-Buttkus, Patricia; Nalbach, Karsten; Cheng, Lizhen; Garrett, Lillian; Irmler, Martin; Kislinger, Georg; Werner, Georg; Rodde, Ramona; Lengger, Christoph; Beckers, Johannes; Zimprich, Annemarie; Hölter, Sabine M; Gailus-Durner, Valerie; Fuchs, Helmut; Hrabe de Angelis, Martin; Wefers, Benedikt; Wurst, Wolfgang; Brill, Monika S; Schifferer, Martina; Lichtenthaler, Stefan F; Behrends, Christian

Asymmetric total synthesis of glauconic and glaucanic acid

格劳酸和格劳酸酸的不对称全合成

Paciorek, Jan; Steinborn, Christian; Gordiy, Igor; Plangger, Immanuel; Schmutzler, Dirk; Barber, David M; Wurst, Klaus; Riniker, Sereina; Magauer, Thomas

Pervasive glycative stress links metabolic imbalance and muscle atrophy in early-onset Parkinson's disease.

普遍存在的糖化应激与早发性帕金森病中的代谢失衡和肌肉萎缩有关

de Mello Natalia Prudente, Berger Michelle Tamara, Lagerborg Kim A, Yan Yingfei, Wettmarshausen Jennifer, Keipert Susanne, Weidner Leopold, Tokarz Janina, Möller Gabriele, Ciciliot Stefano, Walia Safal, Cheng Yiming, Chudenkova Margarita, Artati Anna, Weisenhorn Daniela Vogt, Wurst Wolfgang, Adamski Jerzy, Nilsson Roland, Cossu Giovanni, Boon Agnita, Kievit Anneke, Mandemakers Wim, Bonifati Vincenzo, Jain Mohit, Jastroch Martin, Schmitt-Kopplin Philippe, Perocchi Fabiana, Dyar Kenneth Allen

Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies

对基因敲除小鼠品系进行系统性眼部表型分析,鉴定出与年龄相关性角膜营养不良相关的基因

Briere, Andrew; Vo, Peter; Yang, Benjamin; Adams, David; Amano, Takanori; Amarie, Oana; Berberovic, Zorana; Bower, Lynette; Brown, Steve D M; Burrill, Samantha; Cho, Soo Young; Clementson-Mobbs, Sharon; D'souza, Abigail; Eskandarian, Mohammad; Flenniken, Ann M; Fuchs, Helmut; Gailus-Durner, Valerie; Hérault, Yann; Hrabe de Angelis, Martin; Jin, Shundan; Joynson, Russell; Kang, Yeon Kyung; Kim, Haerim; Masuya, Hiroshi; Meziane, Hamid; Nam, Ki-Hoan; Noh, Hyuna; Nutter, Lauryl M J; Palkova, Marcela; Prochazka, Jan; Raishbrook, Miles Joseph; Riet, Fabrice; Salazar, Jason; Sedlacek, Radislav; Selloum, Mohammed; Seo, Kyoung Yul; Seong, Je Kyung; Shin, Hae-Sol; Shiroishi, Toshihiko; Stewart, Michelle; Svenson, Karen; Tamura, Masaru; Tolentino, Heather; Wells, Sara; Wurst, Wolfgang; Yoshiki, Atsushi; Lanoue, Louise; Lloyd, K C Kent; Leonard, Brian C; Roux, Michel J; McKerlie, Colin; Moshiri, Ala