日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Phase I/II Study of GSK525762 Combined with Fulvestrant in Patients with Hormone Receptor-positive/HER2-negative Advanced or Metastatic Breast Cancer

一项针对激素受体阳性/HER2阴性晚期或转移性乳腺癌患者的GSK525762联合氟维司群的I/II期研究

Cescon, David W; Hilton, John; Morales Murilo, Serafin; Layman, Rachel M; Pluard, Timothy; Yeo, Belinda; Park, In Hae; Provencher, Louise; Kim, Sung-Bae; Im, Young-Hyuck; Wyce, Anastasia; Krishnatry, Anu Shilpa; Hicks, Kirsty; Zhang, Qu; Barbash, Olena; Khaled, Ahmed; Horner, Thierry; Dhar, Arindam; Oliveira, Mafalda; Sparano, Joseph A

A Phase I/II Open-Label Study of Molibresib for the Treatment of Relapsed/Refractory Hematologic Malignancies

一项针对复发/难治性血液系统恶性肿瘤的 Molibresib I/II 期开放标签研究

Dawson, Mark A; Borthakur, Gautam; Huntly, Brian J P; Karadimitris, Anastasios; Alegre, Adrian; Chaidos, Aristeidis; Vogl, Dan T; Pollyea, Daniel A; Davies, Faith E; Morgan, Gareth J; Glass, Jacob L; Kamdar, Manali; Mateos, Maria-Victoria; Tovar, Natalia; Yeh, Paul; Delgado, Regina García; Basheer, Faisal; Marando, Ludovica; Gallipoli, Paolo; Wyce, Anastasia; Krishnatry, Anu Shilpa; Barbash, Olena; Bakirtzi, Evi; Ferron-Brady, Geraldine; Karpinich, Natalie O; McCabe, Michael T; Foley, Shawn W; Horner, Thierry; Dhar, Arindam; Kremer, Brandon E; Dickinson, Michael

Inhibiting PRMT5 induces DNA damage and increases anti-proliferative activity of Niraparib, a PARP inhibitor, in models of breast and ovarian cancer

在乳腺癌和卵巢癌模型中,抑制 PRMT5 可诱导 DNA 损伤并增强 PARP 抑制剂尼拉帕尼的抗增殖活性

Shane O'Brien, Michael Butticello, Christine Thompson, Boris Wilson, Anastasia Wyce, Vivek Mahajan, Ryan Kruger, Helai Mohammad, Andy Fedoriw

Phase 1 Study of Molibresib (GSK525762), a Bromodomain and Extra-Terminal Domain Protein Inhibitor, in NUT Carcinoma and Other Solid Tumors

Molibresib (GSK525762)(一种溴结构域和末端结构域蛋白抑制剂)治疗 NUT 癌和其他实体瘤的 1 期研究

Piha-Paul, Sarina A; Hann, Christine L; French, Christopher A; Cousin, Sophie; Braña, Irene; Cassier, Phillippe A; Moreno, Victor; de Bono, Johann S; Harward, Sara Duckworth; Ferron-Brady, Geraldine; Barbash, Olena; Wyce, Anastasia; Wu, Yuehui; Horner, Thierry; Annan, Meg; Parr, Nigel J; Prinjha, Rabinder K; Carpenter, Christopher L; Hilton, John; Hong, David S; Haas, Naomi B; Markowski, Mark C; Dhar, Arindam; O'Dwyer, Peter J; Shapiro, Geoffrey I

Limited antitumor activity of combined BET and MEK inhibition in neuroblastoma

BET 和 MEK 联合抑制对神经母细胞瘤的抗肿瘤活性有限

Jason R Healy, Lori S Hart, Alexander L Shazad, Maria E Gagliardi, Matthew Tsang, Jimmy Elias, Jacob Ruden, Alvin Farrel, Jo Lynne Rokita, Yimei Li, Anastasia Wyce, Olena Barbash, Vandana Batra, Minu Samanta, John M Maris, Robert W Schnepp

MEK inhibitors overcome resistance to BET inhibition across a number of solid and hematologic cancers

MEK抑制剂能够克服多种实体瘤和血液肿瘤对BET抑制剂的耐药性。

Wyce, Anastasia; Matteo, Jeanne J; Foley, Shawn W; Felitsky, Daniel J; Rajapurkar, Satyajit R; Zhang, Xi-Ping; Musso, Melissa C; Korenchuk, Susan; Karpinich, Natalie O; Keenan, Kathryn M; Stern, Melissa; Mathew, Lijoy K; McHugh, Charles F; McCabe, Michael T; Tummino, Peter J; Kruger, Ryan G; Carpenter, Christopher; Barbash, Olena

BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models

BET抑制剂可沉默MYCN和BCL2的表达,并在神经母细胞瘤模型中诱导细胞毒性。

Wyce, Anastasia; Ganji, Gopinath; Smitheman, Kimberly N; Chung, Chun-Wa; Korenchuk, Susan; Bai, Yuchen; Barbash, Olena; Le, BaoChau; Craggs, Peter D; McCabe, Michael T; Kennedy-Wilson, Karen M; Sanchez, Lydia V; Gosmini, Romain L; Parr, Nigel; McHugh, Charles F; Dhanak, Dashyant; Prinjha, Rab K; Auger, Kurt R; Tummino, Peter J

H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex

H2B泛素蛋白酶Ubp8和Sgf11构成酿酒酵母SAGA复合物内的一个独立功能模块。

Ingvarsdottir, Kristin; Krogan, Nevan J; Emre, N C Tolga; Wyce, Anastasia; Thompson, Natalie J; Emili, Andrew; Hughes, Timothy R; Greenblatt, Jack F; Berger, Shelley L

Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8

通过连续组蛋白H2B泛素化和去泛素化激活转录,由SAGA相关的Ubp8介导

Karl W Henry, Anastasia Wyce, Wan-Sheng Lo, Laura J Duggan, N C Tolga Emre, Cheng-Fu Kao, Lorraine Pillus, Ali Shilatifard, Mary Ann Osley, Shelley L Berger