日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A "Ligand First" Approach toward Selective, Covalent JNK2/3 Inhibitors.

以“配体优先”为导向的选择性共价 JNK2/3 抑制剂策略

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c00884
Wydra Valentin R, Plank Nicole, Zwirner Stefan, Selig Roland, Rasch Alexander, Masberg Benedikt, Lämmerhofer Michael, Zender Lars, Koch Pierre, Albrecht Wolfgang, Laufer Stefan
信号转导
JNK
发表日期：2025
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Screening of Covalent Kinase Inhibitors Yields Hits for Cysteine Protease USP7 / HAUSP

共价激酶抑制剂筛选发现半胱氨酸蛋白酶USP7/HAUSP的有效抑制剂

期刊:Drug Design Development and Therapy
影响因子:5.1
doi:10.2147/DDDT.S513591
Ernst, Larissa N; Jaag, Simon J; Wydra, Valentin R; Masberg, Benedikt; Knappe, Cornelius; Gerstenecker, Stefan; Serafim, Ricardo A M; Liang, Xiaojun Julia; Seidler, Nico J; Lämmerhofer, Michael; Gehringer, Matthias; Boeckler, Frank M
信号转导
SP7
HAUSP
发表日期：2025
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Design, Synthesis, and Molecular Evaluation of S(N)Ar-Reactive N-(6-Fluoro-3-Nitropyridin-2-yl)Isoquinolin-3-Amines as Covalent USP7 Inhibitors Reveals an Unconventional Binding Mode

S(N)Ar反应性N-(6-氟-3-硝基吡啶-2-基)异喹啉-3-胺类化合物作为共价USP7抑制剂的设计、合成和分子评价揭示了一种非常规的结合模式

期刊:Archiv der Pharmazie
影响因子:3.6
doi:10.1002/ardp.70053
Ernst, Larissa N; Stahlecker, Jason; Mier, Finn; Serafim, Ricardo A M; Wydra, Valentin R; Masberg, Benedikt; Jaag, Simon J; Knappe, Cornelius; Lämmerhofer, Michael; Stehle, Thilo; Gehringer, Matthias; Boeckler, Frank M
SP7
发表日期：2025
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