日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Untargeted metabolomics for triaging of cytochrome b inhibitors during Chagas' disease drug discovery

在恰加斯病药物研发过程中,利用非靶向代谢组学对细胞色素b抑制剂进行筛选

MacLeod, A Kenneth; Tulloch, Lindsay B; Tinti, Michele; Edwards, Darren; Wyllie, Susan; Read, Kevin D

Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease

靶向赖氨酰tRNA合成酶的抗锥虫喹唑啉类药物在急性恰加斯病小鼠模型中显示出部分疗效。

Tulloch, Lindsay B; Tawell, Hugh; Taylor, Annie E; Lima, Marta Lopes; Dawson, Alice; Carvalho, Sandra; Wall, Richard J; Corpas-Lopez, Victoriano; Dey, Gourav; Duggan, Jack; Magalhaes, Luma Godoy; Torrie, Leah S; Frame, Laura; Robinson, David; Patterson, Stephen; Tinti, Michele; Weaver, George W; Robinson, William J; Cal, Monica; Kaiser, Marcel; Mäser, Pascal; Sjö, Peter; Perry, Benjamin; Kelly, John M; Francisco, Amanda Fortes; Bhambra, Avninder S; Wyllie, Susan

Use of P450 Enzymes for Late-Stage Functionalization in Drug Discovery

P450酶在药物发现后期功能化中的应用

Poon, Vincent; Bailey, Christopher; Carvalho, Sandra; Patterson, Stephen; Fyfe, James W B; Semenova, Olga; Wrigley, Stephen K; Hopkins, Emily; Manohar, Ravi; Drake, Christopher; Kokubun, Tetsuo; Boyle, John; Kvaerno, Lisbet; Lees, Kristin; Hoffmann, Karl F; Forde-Thomas, Josephine; Wyllie, Susan; Steele, Jonathan; Gilbert, Ian H; Tarver, Gary J

The Thienopyrimidinone Gamhépathiopine Targets the Q(O) Site of Plasmodium falciparum Cytochrome b

噻吩并嘧啶酮类药物Gamhépathiopine靶向恶性疟原虫细胞色素b的Q(O)位点

Wiedemar, Natalie; Milne, Rachel; Carvalho, Sandra; Patterson, Stephen; Bodkin, Mike; Masurier, Nicolas; Lisowski, Vincent; Primas, Nicolas; Verhaeghe, Pierre; Sloan, Graeme M; Wyllie, Susan

Comparative metabolism of conjugated and unconjugated pterins in Crithidia, Leishmania and African trypanosomes

锥虫、利什曼原虫和非洲锥虫中结合型和非结合型蝶呤的代谢比较

Ong, Han B; Wyllie, Susan; Fairlamb, Alan H

ResMAP-a saturation mutagenesis platform enabling parallel profiling of target-specific resistance-conferring mutations in Plasmodium

ResMAP——一种饱和诱变平台,可对疟原虫中靶向特异性抗性突变进行并行分析

Wall, Richard J; MacGowan, Stuart A; Hallyburton, Irene; Syed, Aisha J; Ajay Castro, Sowmya; Dey, Gourav; Milne, Rachel; Patterson, Stephen; Phelan, Jody; Wiedemar, Natalie; Wyllie, Susan

Anti-trypanosomatid drug discovery: progress and challenges

抗锥虫药物研发:进展与挑战

De Rycker, Manu; Wyllie, Susan; Horn, David; Read, Kevin D; Gilbert, Ian H

DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc(1)

DNDI-6174 是一种用于治疗内脏利什曼病的临床前候选药物,其靶点为细胞色素 bc(1)

Braillard, Stéphanie; Keenan, Martine; Breese, Karen J; Heppell, Jacob; Abbott, Michael; Islam, Rafiqul; Shackleford, David M; Katneni, Kasiram; Crighton, Elly; Chen, Gong; Patil, Rahul; Lee, Given; White, Karen L; Carvalho, Sandra; Wall, Richard J; Chemi, Giulia; Zuccotto, Fabio; González, Silvia; Marco, Maria; Deakyne, Julianna; Standing, David; Brunori, Gino; Lyon, Jonathan J; Castañeda-Casado, Pablo; Camino, Isabel; Martinez Martinez, Maria S; Zulfiqar, Bilal; Avery, Vicky M; Feijens, Pim-Bart; Van Pelt, Natascha; Matheeussen, An; Hendrickx, Sarah; Maes, Louis; Caljon, Guy; Yardley, Vanessa; Wyllie, Susan; Charman, Susan A; Chatelain, Eric

Short-course combination treatment for experimental chronic Chagas disease

针对实验性慢性恰加斯病的短期联合治疗

González, Silvia; Wall, Richard J; Thomas, John; Braillard, Stephanie; Brunori, Gino; Camino Díaz, Isabel; Cantizani, Juan; Carvalho, Sandra; Castañeda Casado, Pablo; Chatelain, Eric; Cotillo, Ignacio; Fiandor, Jose M; Francisco, Amanda Fortes; Grimsditch, David; Keenan, Martine; Kelly, John M; Kessler, Albane; Luise, Chiara; Lyon, Jon J; MacLean, Lorna; Marco, Maria; Martin, J Julio; Martinez Martinez, Maria S; Paterson, Christy; Read, Kevin D; Santos-Villarejo, Angel; Zuccotto, Fabio; Wyllie, Susan; Miles, Tim J; De Rycker, Manu

The critical role of mode of action studies in kinetoplastid drug discovery

作用机制研究在动质体药物发现中的关键作用

Fairlamb, Alan H; Wyllie, Susan