Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites
BRD4的共价片段筛选鉴定出一个与乙酰赖氨酸结合位点正交的配体结合位点
期刊:ACS Chemical Biology
影响因子:3.8
doi:10.1021/acschembio.0c00058
Olp, Michael D; Sprague, Daniel J; Goetz, Christopher J; Kathman, Stefan G; Wynia-Smith, Sarah L; Shishodia, Shifali; Summers, Steven B; Xu, Ziyang; Statsyuk, Alexander V; Smith, Brian C