日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tight junction-high and CDH17-positive cell population is the source of colorectal cancer liver metastases.

紧密连接高表达且CDH17阳性的细胞群是结直肠癌肝转移的来源。

Alvarez-Villanueva Daniel, Maqueda María, Harti Dina, Canton Eric, Andrades Evelyn, Bertran Joan, Martínez-Iniesta María, Solé Laura, García-Hernández Violeta, Montoto Ángela, Lobo-Jarne Teresa, Alonso-Marañón Josune, Herrero-Molinero Patricia, Larrubia-Loring Mónica, Tramuns Anna, Wynne Kieran, Bera Indrani, Matallanas David, Villanueva Alberto, Bigas Anna, Iglesias Mar, Espinosa Lluís

Reduced PRC2 function causes asparaginase resistance in T-ALL by decreasing WNT pathway activity

PRC2功能降低会通过降低WNT通路活性,导致T细胞急性淋巴细胞白血病(T-ALL)产生天冬酰胺酶耐药性。

Lefeivre, Thomas; Grosu, Theodora-Ioana; Tudose, Cosmin; Jones, Luke; León, Theresa E; Wynne, Kieran; Oliviero, Giorgio; Smith, Owen P; Trinquand, Amélie; Mansour, Marc R; Ryan, Colm J; Bond, Jonathan

MYCN inhibits TrkC-mediated differentiation in neuroblastoma cells via disruption of the PKA signalling pathway

MYCN通过破坏PKA信号通路抑制神经母细胞瘤细胞中TrkC介导的分化。

Maher, Stephanie; Roe, Andrew; Wynne, Kieran; Zhernovkov, Vadim; Halasz, Melinda

Molecular crowding effects on protein stability in a bacterial proteome

分子拥挤效应对细菌蛋白质组中蛋白质稳定性的影响

McKeever, Kate; Dillon, Eugene T; Wynne, Kieran; Cagney, Gerard

Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure.

抑制 HDAC6 会改变延胡索酸水合酶活性和线粒体结构

Roe Andrew, Dowling Catríona M, D'Arcy Cian, Alencar Rodrigues Daniel, Wang Yu, Hiller Matthew, Keogh Carl, Hollinshead Kate E R, Garre Massimiliano, Cavanagh Brenton, Wynne Kieran, Liu Tianyan, Chen Zhixing, Kerr Emma, McIlroy Marie, H M Prehn Jochen, Schoen Ingmar, Chonghaile Tríona Ní

De novo DUOX2 expression in neutrophil subsets shapes the pathogenesis of intestinal disease

中性粒细胞亚群中DUOX2的新生表达影响肠道疾病的发病机制。

Singh, Ashish K; Ainciburu, Marina; Wynne, Kieran; Bhat, Sajad A; Blanco, Alfonso; Tzani, Ioanna; Akiba, Yasutada; Lalor, Stephen J; Kaunitz, Jonathan; Bourke, Billy; Kelly, Vincent P; Doherty, Glen A; Zerbe, Christa S; Clarke, Colin; Hussey, Séamus; Knaus, Ulla G

Saturated fat exacerbates mitochondrial dysfunction through remodelling of ATP production and inflammation in Barrett's oesophagus compared to monounsaturated fat, particularly in contrast to oesophageal adenocarcinoma

与单不饱和脂肪相比,饱和脂肪会通过重塑 ATP 生成和炎症加剧巴雷特食管中的线粒体功能障碍,尤其与食管腺癌相比更是如此。

Mitchelson, Kathleen A J; O'Connell, Fiona; Wynne, Kieran; Matallanas, David; O'Sullivan, Jacintha; Roche, Helen M

The fibrin-derived peptide FX06 protects human pulmonary endothelial cells against the COVID-19-triggered cytokine storm.

纤维蛋白衍生肽 FX06 可保护人类肺内皮细胞免受 COVID-19 引发的细胞因子风暴的损害

Wang Zhiran, Lebedev Dmitrii, Li Simeng, Rao Sudharshan, Wu Kevin, Doyle Lorcan, Wynne Kieran, Blanco Alfonso, Mysior Margaritha M, Simpson Jeremy C, Scholz Dimitri, Wülfroth Petra, Zacharowski Kai, Kolch Walter, Zhernovkov Vadim, Eissner Günther

Germline Disruption of Retinal Pigment Epithelium-Expressed Zebrafish rlbp1b(-/-) Results in Selective Dim Light Visual Behavior Deficits and Provides a Screening Platform for Evaluating the Pathogenicity of Human RLBP1 Variants.

视网膜色素上皮表达的斑马鱼 rlbp1b(-/-) 的种系破坏导致选择性弱光视觉行为缺陷,并为评估人类 RLBP1 变体的致病性提供了筛选平台

Fehilly John D, McCann Tess, Ruddin Grace, Kaylor Joanna J, Grenville Hannah, Ward Rebecca, Wynne Kieran, Sánchez Alicia Gómez, Strachan Elin, Travis Gabriel H, Collery Ross F, Kennedy Breandán N

Response to Nutrient Stress in the Industrial Model Bacterium Cupriavidus necator: A Thermal Proteome Profiling (TPP) Investigation

工业模式细菌贪铜菌(Cupriavidus necator)对营养胁迫的响应:热蛋白质组学分析(TPP)研究

McKeever, Kate; Tham, Jia-Lynn; Bruch, Manuel; Narancic, Tania; Connor, Kevin O'; Upadhya, Swathi Ramachandra; Ryan, Colm; Dillon, Eugene T; Wynne, Kieran; Cagney, Gerard