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Targeting cellular senescence in dystrophin(-/-)/utrophin(-/-)double knockout mice improves musculoskeletal health and increases lifespan.

针对肌营养不良蛋白(-/-)/肌营养不良蛋白(-/-)双敲除小鼠的细胞衰老进行治疗，可改善肌肉骨骼健康并延长寿命。

doi:10.1016/j.phrs.2025.108016

Gao Xueqin, Ruzbarsky Joseph J, Huard Matthieu, Sajedi S Amir H, Shyu Peter T, Xiao Zuokui, Force Britney S, White Sarah, Ayers Jessica, Wang Bing, Guo X Edward, Huard Johnny

Evaluation of Dexamethasone-Eluting Cell-Seeded Constructs in a Preclinical Canine Model of Cartilage Repair

在犬软骨修复临床前模型中评估地塞米松洗脱细胞接种构建体

期刊:Tissue Engineering Part A

影响因子:2.9

doi:10.1089/ten.tea.2024.0244

Lee, Andy J; Gangi, Lianna R; Hu, Yizhong Jenny; Dinescu, Andreea T; Guo, X Edward; Bozynski, Chantelle C; Kuroki, Keiichi; Stoker, Aaron M; Marra, Kacey G; Ateshian, Gerard A; Cook, James L; Hung, Clark T

Elderly Caribbean Hispanic men have lower tibial stiffness and failure load compared to non-Hispanic White and Black men

与非西班牙裔白人和黑人男性相比，加勒比海地区西班牙裔老年男性的胫骨刚度和失效负荷较低。

期刊:JBMR Plus

影响因子:2.4

doi:10.1093/jbmrpl/ziaf110

Agarwal, Sanchita; Rawal, Ragyie; Germosen, Carmen; Rosillo, Isabella; Lopez, Lynette X; Colon, Ivelisse; Bucovsky, Mariana; Del Orbe, Mildense; Guo, X Edward; Shane, Elizabeth; Walker, Marcella

发表日期：2025

文献求助收藏

Bone microarchitecture assessed by High-resolution peripheral quantitative computed tomography in type 1 diabetes: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study

高分辨率外周定量计算机断层扫描评估1型糖尿病患者的骨微结构：糖尿病控制与并发症试验/糖尿病干预与并发症流行病学研究

期刊:JBMR Plus

影响因子:2.4

doi:10.1093/jbmrpl/ziaf167

Rubin, Mishaela; Kazakia, Galateia; Braffett, Barbara H; Gregory, Naina Sinha; Lin, Ming-Hui; Trapani, Victoria; de Boer, Ian H; Agarwal, Sanchita; Burghardt, Andrew; Guo, X Edward; Gubitosi-Klug, Rose; Schwartz, Ann V

Molecular Mechanisms of DNMT3A-3L-Mediated de novo DNA Methylation on Chromatin

DNMT3A-3L介导的染色质从头DNA甲基化的分子机制

期刊:

影响因子:

doi:10.1101/2025.06.10.658647

Yan, Yan; Zhou, X Edward; Thomas, Stacey L; Liu, Minmin; Lai, Gan-Qiang; Worden, Evan J; Jones, Peter A; Xu, Ting-Hai

Rescuing SERCA2 pump deficiency improves bone mechano-responsiveness in type 2 diabetes by shaping osteocyte calcium dynamics

通过塑造骨细胞钙动力学来挽救 SERCA2 泵缺陷，改善 2 型糖尿病患者的骨骼机械反应

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-024-45023-6

Xi Shao #, Yulan Tian #, Juan Liu #, Zedong Yan #, Yuanjun Ding, Xiaoxia Hao, Dan Wang, Liangliang Shen, Erping Luo, X Edward Guo, Peng Luo, Wenjing Luo, Jing Cai, Da Jing

HR-pQCT reveals marked trabecular and cortical structural deficits in women with pregnancy and lactation-associated osteoporosis (PLO)

HR-pQCT 揭示了妊娠和哺乳期相关骨质疏松症 (PLO) 女性的骨小梁和皮质结构明显缺陷

期刊:Journal of Bone and Mineral Research

影响因子:5.9

doi:10.1093/jbmr/zjae167

Agarwal, Sanchita; El-Najjar, Dany; Kondapalli, Ananya; Kil, Nayoung; Kamanda-Kosseh, Mafo; Bucovsky, Mariana; Colon, Ivelisse; Lappe, Joan M; Stubby, Julie; Recker, Robert R; Guo, X Edward; Shane, Elizabeth; Cohen, Adi

Mechanical and structural properties of articular cartilage and subchondral bone in human osteoarthritic knees

人类骨关节炎膝关节软骨和软骨下骨的力学和结构特性

期刊:Journal of Bone and Mineral Research

影响因子:5.9

doi:10.1093/jbmr/zjae094

Hu, Yizhong Jenny; Yu, Y Eric; Cooper, Herbert J; Shah, Roshan P; Geller, Jeffrey A; Lu, X Lucas; Shane, Elizabeth; Bathon, Joan; Lane, Nancy E; Guo, X Edward

关节炎

发表日期：2024

文献求助收藏

Neuroprotective macromolecular methylprednisolone prodrug nanomedicine prevents glucocorticoid-induced muscle atrophy and osteoporosis in a rat model of spinal cord injury

神经保护性大分子甲基泼尼松龙前药纳米药物可预防大鼠脊髓损伤模型中糖皮质激素诱导的肌肉萎缩和骨质疏松。

期刊:Nanomedicine-Nanotechnology Biology and Medicine

影响因子:4.6

doi:10.1016/j.nano.2024.102773

Qin, Yiwen; Zhao, Wei; Jia, Zhenshan; Bauman, William A; Peng, Yuanzhen; Guo, X Edward; Chen, Zihao; He, Zhiming; Cardozo, Christopher P; Wang, Dong; Qin, Weiping

Mechanisms of DNMT3A-3L-mediated de novo DNA methylation on chromatin

DNMT3A-3L介导的染色质从头DNA甲基化的机制

Targeting cellular senescence in dystrophin(-/-)/utrophin(-/-)double knockout mice improves musculoskeletal health and increases lifespan.

针对肌营养不良蛋白(-/-)/肌营养不良蛋白(-/-)双敲除小鼠的细胞衰老进行治疗，可改善肌肉骨骼健康并延长寿命。

Evaluation of Dexamethasone-Eluting Cell-Seeded Constructs in a Preclinical Canine Model of Cartilage Repair

在犬软骨修复临床前模型中评估地塞米松洗脱细胞接种构建体

Elderly Caribbean Hispanic men have lower tibial stiffness and failure load compared to non-Hispanic White and Black men

与非西班牙裔白人和黑人男性相比，加勒比海地区西班牙裔老年男性的胫骨刚度和失效负荷较低。

Bone microarchitecture assessed by High-resolution peripheral quantitative computed tomography in type 1 diabetes: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study

高分辨率外周定量计算机断层扫描评估1型糖尿病患者的骨微结构：糖尿病控制与并发症试验/糖尿病干预与并发症流行病学研究

Molecular Mechanisms of DNMT3A-3L-Mediated de novo DNA Methylation on Chromatin

DNMT3A-3L介导的染色质从头DNA甲基化的分子机制

Rescuing SERCA2 pump deficiency improves bone mechano-responsiveness in type 2 diabetes by shaping osteocyte calcium dynamics

通过塑造骨细胞钙动力学来挽救 SERCA2 泵缺陷，改善 2 型糖尿病患者的骨骼机械反应

HR-pQCT reveals marked trabecular and cortical structural deficits in women with pregnancy and lactation-associated osteoporosis (PLO)

HR-pQCT 揭示了妊娠和哺乳期相关骨质疏松症 (PLO) 女性的骨小梁和皮质结构明显缺陷

Mechanical and structural properties of articular cartilage and subchondral bone in human osteoarthritic knees

人类骨关节炎膝关节软骨和软骨下骨的力学和结构特性

Neuroprotective macromolecular methylprednisolone prodrug nanomedicine prevents glucocorticoid-induced muscle atrophy and osteoporosis in a rat model of spinal cord injury

神经保护性大分子甲基泼尼松龙前药纳米药物可预防大鼠脊髓损伤模型中糖皮质激素诱导的肌肉萎缩和骨质疏松。