日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Actinomycin D enhances killing of cancer cells by immunotoxin RG7787 through activation of the extrinsic pathway of apoptosis.

放线菌素 D 通过激活细胞凋亡的外源途径,增强免疫毒素 RG7787 对癌细胞的杀伤作用

Liu Xiu Fen, Xiang Laiman, Zhou Qi, Carralot Jean-Philippe, Prunotto Marco, Niederfellner Gerhard, Pastan Ira

Recombinant Immunotoxin with T-cell Epitope Mutations That Greatly Reduce Immunogenicity for Treatment of Mesothelin-Expressing Tumors

用于治疗间皮素表达肿瘤的T细胞表位突变重组免疫毒素可显著降低免疫原性

Mazor, Ronit; Zhang, Jingli; Xiang, Laiman; Addissie, Selamawit; Awuah, Prince; Beers, Richard; Hassan, Raffit; Pastan, Ira

Antitumor effects of immunotoxins are enhanced by lowering HCK or treatment with SRC kinase inhibitors

降低HCK水平或使用SRC激酶抑制剂治疗可增强免疫毒素的抗肿瘤作用。

Liu, Xiu-Fen; Xiang, Laiman; FitzGerald, David J; Pastan, Ira

A recombinant immunotoxin against the tumor-associated antigen mesothelin reengineered for high activity, low off-target toxicity, and reduced antigenicity

一种针对肿瘤相关抗原间皮素的重组免疫毒素,经重新设计后具有高活性、低脱靶毒性和降低的抗原性。

Weldon, John E; Xiang, Laiman; Zhang, Jingli; Beers, Richard; Walker, Dawn A; Onda, Masanori; Hassan, Raffit; Pastan, Ira

Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia cell line KOPN-8

DPH1启动子的甲基化导致急性淋巴细胞白血病细胞系KOPN-8产生免疫毒素抗性。

Hu, Xiaobo; Wei, Hui; Xiang, Laiman; Chertov, Oleg; Wayne, Alan S; Bera, Tapan K; Pastan, Ira

A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity

通过添加二硫键提高稳定性的重组免疫毒素的免疫原性降低。

Liu, Wenhai; Onda, Masanori; Kim, Changhoon; Xiang, Laiman; Weldon, John E; Lee, Byungkook; Pastan, Ira

A recombinant immunotoxin targeting CD22 with low immunogenicity, low nonspecific toxicity, and high antitumor activity in mice

一种靶向CD22的重组免疫毒素,具有低免疫原性、低非特异性毒性和高抗肿瘤活性(小鼠模型)。

Hansen, Johanna K; Weldon, John E; Xiang, Laiman; Beers, Richard; Onda, Masanori; Pastan, Ira