STUB1 downregulates TOP2A through a dual mechanism of ubiquitination and FOXM1-mediated transcription repression, suppressing breast cancer growth and enhancing sensitivity to chemotherapy
STUB1通过泛素化和FOXM1介导的转录抑制双重机制下调TOP2A的表达，从而抑制乳腺癌细胞的生长并增强其对化疗的敏感性。
期刊:Cellular & Molecular Biology Letters
影响因子:10.2
doi:10.1186/s11658-026-00902-2
Yue, Baohui; Xiang, Qiaoling; Qiu, Huimin; Huang, Mingxiang; Qi, Mengxin; Yi, Xianglan; Zhou, Sheng; Xiong, Jing
FOXM1
细胞生物学
表观遗传
乳腺癌
泛素化
肿瘤
肿瘤免疫
