文献库，生知库 | 链接生命科学的每一步

Liu Xin, Liu Qian, Guo Dong, Zhao Zezhou, Wang Jing, Xiang Yaoxian, Wang Kangjie, Yang Lijun, Zhu Ke, Wang Li, Li Ruofan, Gao Xu, Zhang Chan, Cheng Yurong, Yan Dong, Tong Yingying

肠癌

免疫/内分泌

VISTA

发表日期：2026

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The glycolytic enzyme PGK1 phosphorylates MORC2 to Confer radioresistance in pancreatic ductal adenocarcinoma

糖酵解酶PGK1磷酸化MORC2，赋予胰腺导管腺癌放射抗性。

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-025-08177-9

Tong, Yingying; Liu, Xin; Liu, Qian; Wang, Jing; Xiang, Yaoxian; Wang, Kangjie; Zhao, Zezhou; Zhu, Ke; Yang, Lijun; Wang, Li; Guo, Dong; Lu, Zhimin; Yan, Dong

Knockdown NEK7 stimulates anti-tumor immune responses by NLRP3/PD-L1 signaling in esophageal cancer.

敲除 NEK7 可通过 NLRP3/PD-L1 信号通路刺激食管癌中的抗肿瘤免疫反应

期刊:Cancer Immunology Immunotherapy

影响因子:5.1

doi:10.1007/s00262-025-04057-5

Wang Li, Cheng Yurong, Li Weiqiang, Wang Jing, Liu Zhe, Xiang Yaoxian, Liu Xin, Wang Kangjie, Yan Dong

Identification of Metabolic Characteristic-Pancreatic Ductal Adenocarcinoma Associations Using Mendelian Randomization and Metabolomics

利用孟德尔随机化和代谢组学鉴定代谢特征与胰腺导管腺癌的关联

期刊:Journal of Gastrointestinal Cancer

影响因子:1.6

doi:10.1007/s12029-025-01173-4

Xiang, Yaoxian; Zhang, Chan; Wang, Jing; Cheng, Yurong; Wang, Kangjie; Wang, Li; Tong, Yingying; Yan, Dong

The roles of OGT and its mechanisms in cancer

OGT在癌症中的作用及其机制

期刊:Cell and Bioscience

影响因子:6.2

doi:10.1186/s13578-024-01301-w

Liu, Xin; Wang, Jing; Xiang, Yaoxian; Wang, Kangjie; Yan, Dong; Tong, Yingying

High-Risk Hepatocellular Carcinoma: Hepatic Arterial Infusion Chemotherapy versus Transarterial Chemoembolization

高危肝细胞癌：肝动脉灌注化疗与经动脉化疗栓塞术的比较

期刊:Journal of Hepatocellular Carcinoma

影响因子:3.4

doi:10.2147/JHC.S455953

Zhang, Baogen; Huang, Biqing; Yang, Fan; Yang, Jiandong; Kong, Man; Wang, Jing; Xiang, Yaoxian; Wang, Kangjie; Peng, Ruchen; Yang, Kun; An, Chao; Yan, Dong

The association between inflammatory cytokines and sarcopenia-related traits: a bi-directional Mendelian randomization study

炎症细胞因子与肌肉减少症相关性状之间的关联：一项双向孟德尔随机化研究

期刊:European Journal of Clinical Nutrition

影响因子:3.3

doi:10.1038/s41430-024-01486-w

Wang, Jing; Xiang, Yaoxian; Wu, Lihui; Zhang, Chan; Han, Baojuan; Cheng, Yurong; Tong, Yingying; Yan, Dong; Wang, Li

Role of blood metabolites in mediating the effect of gut microbiome on the mutated-RAS/BRAF metastatic colorectal cancer-specific survival

血液代谢物在介导肠道微生物群对突变型RAS/BRAF转移性结直肠癌特异性生存的影响中的作用

期刊:International Journal of Colorectal Disease

影响因子:2.3

doi:10.1007/s00384-024-04686-9

Xiang, Yaoxian; Zhang, Chan; Wang, Jing; Cheng, Yurong; Wang, Kangjie; Wang, Li; Tong, Yingying; Yan, Dong

Identification of host gene-microbiome associations in colorectal cancer patients using mendelian randomization

利用孟德尔随机化方法鉴定结直肠癌患者宿主基因-微生物组关联

期刊:Journal of Translational Medicine

影响因子:7.5

doi:10.1186/s12967-023-04335-9

Xiang, Yaoxian; Zhang, Chan; Wang, Jing; Cheng, Yurong; Wang, Li; Tong, Yingying; Yan, Dong

Comparison of the efficacy and safety of third-line treatments for advanced gastric cancer: A systematic review and network meta-analysis

晚期胃癌三线治疗疗效和安全性比较：系统评价和网络荟萃分析

期刊:Frontiers in Oncology

影响因子:3.3

doi:10.3389/fonc.2023.1118820

Zhang, Chan; Xiang, Yaoxian; Wang, Jing; Yan, Dong

Hyperglycemia drives lmmune evasion in colorectal cancer through VISTA stabilization.

高血糖通过 VISTA 稳定作用驱动结直肠癌的免疫逃逸。

The glycolytic enzyme PGK1 phosphorylates MORC2 to Confer radioresistance in pancreatic ductal adenocarcinoma

糖酵解酶PGK1磷酸化MORC2，赋予胰腺导管腺癌放射抗性。

Knockdown NEK7 stimulates anti-tumor immune responses by NLRP3/PD-L1 signaling in esophageal cancer.

敲除 NEK7 可通过 NLRP3/PD-L1 信号通路刺激食管癌中的抗肿瘤免疫反应

Identification of Metabolic Characteristic-Pancreatic Ductal Adenocarcinoma Associations Using Mendelian Randomization and Metabolomics

利用孟德尔随机化和代谢组学鉴定代谢特征与胰腺导管腺癌的关联

The roles of OGT and its mechanisms in cancer

OGT在癌症中的作用及其机制

High-Risk Hepatocellular Carcinoma: Hepatic Arterial Infusion Chemotherapy versus Transarterial Chemoembolization

高危肝细胞癌：肝动脉灌注化疗与经动脉化疗栓塞术的比较

The association between inflammatory cytokines and sarcopenia-related traits: a bi-directional Mendelian randomization study

炎症细胞因子与肌肉减少症相关性状之间的关联：一项双向孟德尔随机化研究

Role of blood metabolites in mediating the effect of gut microbiome on the mutated-RAS/BRAF metastatic colorectal cancer-specific survival

血液代谢物在介导肠道微生物群对突变型RAS/BRAF转移性结直肠癌特异性生存的影响中的作用

Identification of host gene-microbiome associations in colorectal cancer patients using mendelian randomization

利用孟德尔随机化方法鉴定结直肠癌患者宿主基因-微生物组关联

Comparison of the efficacy and safety of third-line treatments for advanced gastric cancer: A systematic review and network meta-analysis

晚期胃癌三线治疗疗效和安全性比较：系统评价和网络荟萃分析