日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

DeepDegradome: A structure-aware deep learning framework for PROTAC and ligand generation against protein targets

DeepDegradome:一种面向蛋白质靶点的结构感知深度学习框架,用于生成PROTAC和配体

Hu, Qiaoyu; Cao, Yu; Ren, PengXuan; Zhang, Xianglei; Li, Fenglei; Zhang, Xueyuan; Cai, Fengyu; Zhang, Ran; Zhou, Yongqi; Mei, Lianghe; Bai, Fang

Tau seeds from Alzheimer's disease brains trigger tau spread in macaques while oligomeric-Aβ mediates pathology maturation

阿尔茨海默病患者大脑中的 Tau 种子会引发恒河猴体内的 Tau 扩散,而寡聚 Aβ 则会介导病理成熟

Morgane Darricau, Changsong Dou, Remi Kinet, Tao Zhu, Li Zhou, Xianglei Li, Aurélie Bedel, Stéphane Claverol, Caroline Tokarski, Taxiarchis Katsinelos, William A McEwan, Ling Zhang, Ran Gao, Mathieu Bourdenx, Benjamin Dehay, Chuan Qin, Erwan Bezard, Vincent Planche

Holocene climate change in southern Oman deciphered by speleothem records and climate model simulations

通过洞穴沉积物记录和气候模型模拟解读阿曼南部全新世气候变化

Ye Tian, Dominik Fleitmann, Qiong Zhang, Lijuan Sha, Jasper A Wassenburg, Josefine Axelsson, Haiwei Zhang, Xianglei Li, Jun Hu, Hanying Li, Liang Zhao, Yanjun Cai, Youfeng Ning, Hai Cheng

Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia

p62 依赖性自噬降解 NLRP3 可通过维持小胶质细胞的吞噬功能改善阿尔茨海默病患者的认知功能

Dongyuan Zhang, Yu Zhang, Jirong Pan, Jingjing Cao, Xiuping Sun, Xianglei Li, Ling Zhang, Chuan Qin

Whole-genome resequencing reveals genetic differences and the genetic basis of parapodium number in Russian and Chinese Apostichopus japonicus

全基因组重测序揭示了俄罗斯和中国日本刺猬(Apostichopus japonicus)的遗传差异及其侧足数量的遗传基础

Guo, Chao; Zhang, Xianglei; Li, Yuanxin; Xie, Jiahui; Gao, Pingping; Hao, Pengfei; Han, Lingshu; Zhang, Jinyuan; Wang, Wenpei; Liu, Peng; Ding, Jun; Chang, Yaqing

Hydroclimate variability in the Caribbean during North Atlantic Heinrich cooling events (H8 and H9)

北大西洋海因里希冷却事件期间加勒比海地区的水文气候变化(H8 和 H9)

Yassine Ait Brahim, Matthew C Peros, André E Viau, Mercedes Liedtke, Jesús M Pajón, Julio Valdes, Xianglei Li, R Lawrence Edwards, Eduard G Reinhardt, Frank Oliva

Longitudinal assessment of motor function following the unilateral intrastriatal 6-hydroxydopamine lesion model in mice

小鼠单侧纹状体内 6-羟基多巴胺损伤模型后运动功能的纵向评估

Xiuping Sun, Xianglei Li, Ling Zhang, Yu Zhang, Xiaolong Qi, Siyuan Wang, Chuan Qin

Comparison of the expression and toxicity of AAV2/9 carrying the human A53T α-synuclein gene in presence or absence of WPRE

存在或不存在 WPRE 的情况下携带人类 A53T α-突触核蛋白基因的 AAV2/9 的表达和毒性比较

Xiuping Sun, Xuan Yu, Ling Zhang, Wenjie Zhao, Manshi Wang, Yu Zhang, Xianglei Li, Ran Gao, Ludivine S Breger, Sandra Dovero, Gregory Porras, Pierre-Olivier Fernagut, Benjamin Dehay, Erwan Bezard, Chuan Qin

Comprehensive Proteomic Profiling of Urinary Exosomes and Identification of Potential Non-invasive Early Biomarkers of Alzheimer's Disease in 5XFAD Mouse Model

5XFAD 小鼠模型中尿液外泌体的全面蛋白质组学分析和阿尔茨海默病潜在非侵入性早期生物标志物的鉴定

Zhiqi Song, Yanfeng Xu, Ling Zhang, Li Zhou, Yu Zhang, Yunlin Han, Xianglei Li, Pin Yu, Yajin Qu, Wenjie Zhao, Chuan Qin

PINK1 Deficiency Ameliorates Cisplatin-Induced Acute Kidney Injury in Rats

PINK1 缺乏可改善大鼠顺铂诱发的急性肾损伤

Li Zhou, Ling Zhang, Yu Zhang, Xuan Yu, Xiuping Sun, Tao Zhu, Xianglei Li, Wei Liang, Yunlin Han, Chuan Qin