日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Investigation of a clinical trial drug VV261 as a potent antiviral candidate against Chikungunya virus

对临床试验药物VV261作为对抗基孔肯雅病毒的有效抗病毒候选药物进行研究

期刊:Signal Transduction and Targeted Therapy
影响因子:52.7
doi:10.1038/s41392-025-02567-3
Zhang, Yumin; Tang, Sheng; Chen, Lu; Song, Shufen; Cao, Junyuan; Tian, Guanghui; Xiao, Gengfu; Shen, Jingshan; Zhang, Leike
微生物学
发表日期：2026
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Structure-Based Development of Ultra-Broad-Spectrum 3C-Like Protease Inhibitors

基于结构的超广谱3C样蛋白酶抑制剂的开发

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202512342
Su, Haixia; Nie, Tianqing; Chen, Guofeng; Xiong, Muya; Zhang, Yumin; Wu, Guoqing; You, Mengyuan; Xie, Hang; He, Jian; Xiong, Yanchao; Hu, Hangchen; Zhao, Wenfeng; Li, Minjun; Xiao, Gengfu; Zhang, Leike; Xu, Yechun
发表日期：2026
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FDA-approved IMPDH inhibitors synergize with ribavirin to inhibit respiratory syncytial virus by interfering with purine de novo synthesis

FDA批准的IMPDH抑制剂与利巴韦林协同作用，通过干扰嘌呤从头合成来抑制呼吸道合胞病毒。

期刊:Emerging Microbes & Infections
影响因子:7.5
doi:10.1080/22221751.2026.2640289
Hu, Huina; Wang, Qingxing; Ai, Qiangyun; Zhou, Peiwen; He, Yang; Ye, Zuodong; Ma, Kaixiong; Zhou, Minmin; Huang, Shanzhi; Wang, Lei; Qi, Nan; Xiao, Gengfu; Wang, Shaobo
微生物学
发表日期：2026
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A clinical SARS-CoV-2 Mpro inhibitor blocks replication of multiple enteroviruses and confers oral in vivo protection in animal models

一种临床SARS-CoV-2 Mpro抑制剂可阻断多种肠道病毒的复制，并在动物模型中提供口服体内保护作用。

期刊:PLoS Pathogens
影响因子:4.9
doi:10.1371/journal.ppat.1014051
Ye, Zhengyu; Dai, Wenhao; Zhang, Shaolin; Xiang, Yingchun; Wang, Jinlin; Zhang, Yumin; Cao, Wenyuan; Neyts, Johan; Li, Zuyi; Feng, Fan; Xiao, Gengfu; Liu, Hong; Cao, Junyuan; Zhang, Lei-Ke
微生物学
SARS-CoV-2
发表日期：2026
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Dynamic Cap-Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

猴痘病毒I7L蛋白酶的动态帽介导底物进入和强效抑制剂设计

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202501625
Su, Haixia; Wu, Guoqing; Xiong, Muya; Wang, Yuhang; Cao, Junyuan; You, Mengyuan; Xiang, Yingchun; Nie, Tianqing; Li, Minjun; Xiao, Gengfu; Zhang, Leike; Shao, Qiang; Xu, Yechun
微生物学
猴痘
Monkey
发表日期：2025
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The oral nucleoside drug VV116 is a promising candidate for treating Nipah virus infection

口服核苷类药物VV116是治疗尼帕病毒感染的一种很有前景的候选药物。

期刊:Emerging Microbes & Infections
影响因子:7.5
doi:10.1080/22221751.2025.2587983
Zhang, Yumin; Yao, Yanfeng; Song, Shufen; Gao, Ge; Peng, Yun; Liu, Hang; Chen, Miaoyu; Zheng, Wei; Tian, Guanghui; Xie, Yuanchao; Shen, Jingshan; Xiao, Gengfu; Hu, Tianwen; Shan, Chao; Zhang, Leike
炎症/感染
微生物学
发表日期：2025
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Structure-guided design of a prefusion GPC trimer induces neutralizing responses against LASV

结构导向设计的融合前GPC三聚体可诱导针对LASV的中和反应

期刊:NPJ Vaccines
影响因子:6.5
doi:10.1038/s41541-025-01090-4
Wang, Shaoyan; Li, Ruihua; Pan, Xiaoyan; Wang, Meirong; Wu, Yan; Li, Yaohui; Huang, Xiaoyan; Zhu, Rui; Wang, Xiaolin; Zhang, Yue; Yang, Yilong; Zhang, Jun; Xiao, Gengfu; Zai, Xiaodong; Xu, Junjie; Chen, Wei
发表日期：2025
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Discovery and mechanistic insights of dibenzoylmethane as a broad spectrum inhibitor of coronavirus.

二苯甲酰甲烷作为冠状病毒广谱抑制剂的发现和机制研究

期刊:PLoS Pathogens
影响因子:4.9
doi:10.1371/journal.ppat.1013492
Sun Yuan, Shu Xiaoyang, Chen Lu, Shang Weijuan, Zhang Yumin, Xiao Gengfu, Zhang Leike
信号转导
发表日期：2025
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Eltrombopag, an FDA-approved drug, inhibits dengue virus type 2 by targeting NS2B-NS3 protease.

艾曲波帕是一种经 FDA 批准的药物，它通过靶向 NS2B-NS3 蛋白酶来抑制 2 型登革病毒

期刊:Virologica Sinica
影响因子:4
doi:10.1016/j.virs.2025.05.009
Zhu Xuerui, Gao Xiao, Wu Yan, Lu Jia, Chen Xinlan, Zhao Chenshu, Li Haoyu, Zhang Zhongfa, Liu Shuwen, Xiao Gengfu, Pan Xiaoyan
免疫/内分泌
发表日期：2025
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An orally available 4'-fluorouridine prodrug inhibits SFTSV and LCMV infection

口服的4'-氟尿苷前药可抑制SFTSV和LCMV感染

期刊:Journal of Virology
影响因子:3.8
doi:10.1128/jvi.01172-25
Jian, Xiaoqin; Hu, Tianwen; Xu, Huan; Wen, Yuxi; Zhang, Yumin; Xu, Mengwei; Jiang, Xiaming; Cao, Junyuan; Xiang, Li; Shen, Jingshan; Tian, Guanghui; Xiao, Gengfu; Zhang, Leike
炎症/感染
发表日期：2025
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