Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis.
将 MDM2 抑制剂 RG7388 用于 TP53 突变型 NSCLC：通过 ROS/p-p38/NOXA/caspase-3/GSDME 轴的 p53 非依赖性细胞焦亡机制
期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-07770-2
Tang Gaoyan, Cao Xuelei, Chen Jiaqi, Hui Fu, Xu Na, Jiang Yiqing, Lu Hongmin, Xiao Haifeng, Liang Xiuming, Ma Mingzhe, Qian Yu, Liu Dongli, Wang Zhenlu, Liu Shuzhen, Yu Guohua, Sun Lei
