日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A druggable redox switch on SHP1 controls macrophage inflammation

SHP1 上的可药物调控的氧化还原开关控制巨噬细胞炎症

Ng, Mei Ying; Nix, Meredith N; Du, Guangyan; Davidek, Ivan; Burger, Nils; Shin, Sanghee; Toenjes, Sean; Takeda, Haruna; Cheah Xin Yan, Megan; Zhang, Bingsen; Xiao, Haopeng; Wei, Shelley M; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Wales, Thomas E; Engen, John R; Mills, Evanna L; Che, Jianwei; Zhang, Tinghu; Gray, Nathanael S; Chouchani, Edward T

Hepatic glutathione depletion ameliorates MASLD through selective protein oxidation and inhibition of lipogenesis.

肝脏谷胱甘肽耗竭可通过选择性蛋白质氧化和抑制脂肪生成来改善 MASLD。

Liu Xiang-Yu, Wang Guoxiao, Yu Yingying, Xiao Haopeng, Oh-Hashi Kentaro, Shi Xu, Zheng Shuning, Gerszten Robert, Kahn C Ronald

Diverse bacterial pattern recognition receptors sense the conserved phage proteome

多种细菌模式识别受体能够感知保守的噬菌体蛋白质组。

Lee, Hyunbin; Luengo-Woods, Sofia; Zhang, Jianxiu; Makarova, Kira S; Wolf, Yuri I; Chiu, Collin; Evans, Simone A; Chen, Junyi; Xiao, Haopeng; Feng, Liang; Koonin, Eugene V; Gao, Alex

Covariation MS uncovers a protein that controls cysteine catabolism

共变质谱分析揭示了一种控制半胱氨酸分解代谢的蛋白质

Xiao, Haopeng; Ordonez, Martha; Fink, Emma C; Covington, Taylor A; Woldemichael, Hilina B; Chen, Junyi; Jain, Mika Sarkin; Rohatgi, Milan H; Wei, Shelley M; Burger, Nils; Sharif, Muneeb A; Jan, Julius; Wang, Yaoyu; Petrocelli, Jonathan J; Blackmore, Katherine; Smythers, Amanda L; Zhang, Bingsen; Gilbert, Matthew; Cheong, Hakyung; Khetarpal, Sumeet A; Smith, Arianne; Bogoslavski, Dina; Lei, Yu; Vaites, Laura Pontano; McAllister, Fiona E; Van Bruggen, Nick; Donovan, Katherine A; Huttlin, Edward L; Mills, Evanna L; Fischer, Eric S; Chouchani, Edward T

The human zinc-binding cysteine proteome.

人类锌结合半胱氨酸蛋白质组

Burger Nils, Mittenbühler Melanie J, Xiao Haopeng, Shin Sanghee, Wei Shelley M, Henze Erik K, Schindler Sebastian, Mehravar Sepideh, Wood David M, Petrocelli Jonathan J, Sun Yizhi, Sprenger Hans-Georg, Latorre-Muro Pedro, Smythers Amanda L, Bozi Luiz H M, Darabedian Narek, Zhu Yingde, Seo Hyuk-Soo, Dhe-Paganon Sirano, Che Jianwei, Chouchani Edward T

Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology.

线粒体复合物 III 衍生的 ROS 会放大星形胶质细胞的免疫代谢变化,并促进痴呆症的病理发展。

Barnett Daniel, Zimmer Till S, Booraem Caroline, Palaguachi Fernando, Meadows Samantha M, Xiao Haopeng, Wong Man Ying, Luo Wenjie, Gan Li, Chouchani Edward T, Orr Anna G, Orr Adam L

Monocarboxylate transporters facilitate succinate uptake into brown adipocytes

单羧酸转运蛋白促进琥珀酸进入棕色脂肪细胞。

Reddy, Anita; Winther, Sally; Tran, Nhien; Xiao, Haopeng; Jakob, Josefine; Garrity, Ryan; Smith, Arianne; Ordonez, Martha; Laznik-Bogoslavski, Dina; Rothstein, Jeffrey D; Mills, Evanna L; Chouchani, Edward T

Reactive oxygen species from mitochondrial complex III are induced by NCLX to promote astrocytic STAT3‐linked transcription and dementia‐related pathology

NCLX诱导线粒体复合物III产生活性氧,从而促进星形胶质细胞STAT3相关转录和痴呆相关病理。

Barber, Sheila A; Bruett, Linda; Douglass, Brian R; Herbst, David S; Zink, M Christine; Clements, Janice E; Barnett, Daniel; Zimmer, Till S; Booraem, Caroline; Palaguachi, Fernando; Meadows, Samantha M; Xiao, Haopeng; Chouchani, Edward T; Orr, Anna G; Orr, Adam L

IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis

IRF3 通过 ISG15 介导的糖酵解重编程来降低脂肪组织产热

Yan, Shuai; Kumari, Manju; Xiao, Haopeng; Jacobs, Christopher; Kochumon, Shihab; Jedrychowski, Mark; Chouchani, Edward; Ahmad, Rasheed; Rosen, Evan D

Sample multiplexing for targeted pathway proteomics in aging mice

衰老小鼠靶向通路蛋白质组学的多重样本分析

Yu, Qing; Xiao, Haopeng; Jedrychowski, Mark P; Schweppe, Devin K; Navarrete-Perea, Jose; Knott, Jeffrey; Rogers, John; Chouchani, Edward T; Gygi, Steven P