日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Orthosteric STING inhibition elucidates molecular correction of SAVI STING.

正构 STING 抑制阐明了 SAVI STING 的分子矫正

Xie Tao, Ruzanov Max, Critton David, Merselis Leidy, Naglich Joseph, Sack John S, Zhang Ping, Xie Chunshan, Tredup Jeffrey, Stine Laurel B, Messier Cameron, Hope David L, Caceres-Cortes Janet, Mueller Luciano, Dyckman Alaric J, Newitt John A, Choudhury Asmita, Wilson Stephen C

Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach

基于结构的新型TLR7/8激动剂有效载荷设计,可实现免疫调节偶联物策略

Poudel, Yam B; Lo, Julian C; Norris, Derek J; Cox, Matthew; He, Liqi; Johnson, Walter L; A M Subbaiah, Murugaiah; Mondal, Santigopal; Thangavel, Soodamani; Subramani, Lakshumanan; Reddy, Maheswara; Jain, Suraksha; Weiss, Dahlia R; Sivaprakasam, Prasanna; Critton, David; Mulligan, Dawn; Xie, Chunshan; Dhar, Payal; Li, Yvonne; Sega, Emanuela; Yamazoe, Sayumi; Gavai, Ashvinikumar V; Mathur, Arvind; Zapf, Christoph W; Chekler, Eugene P

Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology

发现新型TLR7激动剂作为全身性药物与抗PD-1抗体联合用于免疫肿瘤学

Poudel, Yam B; He, Liqi; Cox, Matthew; Zhang, Qian; Johnson, Walter L; Cong, Qiang; Cheng, Heng; Chowdari, Naidu S; Tarby, Christine; Donnell, Andrew F; Broekema, Matthais; O'Malley, Daniel P; Zhang, Yong; A M Subbaiah, Murugaiah; Kumar, Boda Vijay; Subramani, Lakshumanan; Wang, Bei; Li, Yi-Xin; Sivaprakasam, Prasanna; Critton, David; Mulligan, Dawn; Sandhu, Bhupindar; Xie, Chunshan; Ramakrishnan, Radha; Nagar, Jignesh; Dudhgaonkar, Shailesh; Oderinde, Martins S; Murtaza, Anwar; Schieven, Gary L; Mathur, Arvind; Gavai, Ashvinikumar V; Vite, Gregory; Gangwar, Sanjeev

Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology

鉴定和优化小分子吡唑并嘧啶类TLR7激动剂在免疫肿瘤学中的应用

He, Liqi; Zhang, Meng Yao; Cox, Matthew; Zhang, Qian; Donnell, Andrew F; Zhang, Yong; Tarby, Christine; Gill, Patrice; Subbaiah, Murugaiah A M; Ramar, Thangeswaran; Reddy, Maheswara; Puttapaka, Vijaya; Li, Yi-Xin; Sivaprakasam, Prasanna; Critton, David; Mulligan, Dawn; Xie, Chunshan; Ramakrishnan, Radha; Nagar, Jignesh; Dudhgaonkar, Shailesh; Murtaza, Anwar; Oderinde, Martins S; Schieven, Gary L; Mathur, Arvind; Gavai, Ashvinikumar V; Vite, Gregory; Gangwar, Sanjeev; Poudel, Yam B

Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties

BET抑制剂作为潜在癌症治疗药物的开发:药代动力学特性的优化

Hill, Matthew D; Fang, Haiquan; Norris, Derek; Delucca, George V; Huang, Hong; DeBenedetto, Mikkel; Quesnelle, Claude; Schmitz, William D; Tokarski, John S; Sheriff, Steven; Yan, Chunhong; Fanslau, Caroline; Haarhoff, Zuzana; Huang, Christine; Kramer, Melissa; Madari, Shilpa; Menard, Krista; Monereau, Laura; Morrison, John; Raghavan, Nirmala; Shields, Eric E; Simmermacher-Mayer, Jean; Sinz, Michael; Tye, Ching Kim; Westhouse, Richard; Xie, Chunshan; Zhang, Haiying; Zhang, Lisa; Zvyaga, Tatyana; Lee, Francis; Gavai, Ashvinikumar V; Degnan, Andrew P

DNA-Model-Based Design and Execution of Some Fused Benzodiazepine Hybrid Payloads for Antibody-Drug Conjugate Modality

基于DNA模型的融合苯二氮卓类杂合有效载荷的设计与实现及其在抗体-药物偶联物中的应用

Sivaprakasam, Prasanna; McDonald, Ivar; Iwuagwu, Christiana; Chowdari, Naidu S; Peese, Kevin M; Langley, David R; Cheng, Heng; Luzung, Michael R; Schmidt, Michael A; Zheng, Bin; Tan, Yichen; Cho, Patricia; Rakshit, Souvik; Lakshminarasimhan, Thirumalai; Guturi, Sivakrishna; Kanagavel, Kishorekumar; Kanusu, Umamaheswararao; Niyogi, Ankita G; Sidhar, Somprabha; Vaidyanathan, Rajappa; Eastgate, Martin D; Kotapati, Srikanth; Deshpande, Madhura; Pan, Chin; Cardarelli, Pina M; Xie, Chunshan; Rao, Chetana; Holder, Patrick; Sarma, Ganapathy; Vite, Gregory; Gangwar, Sanjeev

Synthesis, structure-activity relationship studies and evaluation of a TLR 3/8/9 agonist and its analogues

TLR 3/8/9激动剂及其类似物的合成、构效关系研究和评价

Sarkar, Anindya; Galasiti Kankanamalage, Anushka C; Zhang, Qian; Cheng, Heng; Sivaprakasam, Prasanna; Naglich, Joseph; Xie, Chunshan; Gangwar, Sanjeev; Boger, Dale L