日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

1-Hydroxy-1,8-napthyridinone (DHN) Analogs Potently Inhibit Monkeypox Virus Resolvase (Mpr)

1-羟基-1,8-萘啶酮 (DHN) 类似物可有效抑制猴痘病毒分解酶 (Mpr)

Offei, Samuel; Mahoney, Jacob P; Wang, Ziyue; Pant, Anil; Ryu, Won Hee; Katekar, Roshan; Xie, Jiashu; Yang, Zhilong; Wang, Zhengqiang

Methylation Enables Sensitive LC-MS/MS Quantification of Ciclopirox in a Mouse Pharmacokinetics Study

甲基化作用使得在小鼠药代动力学研究中能够对环吡咯烷酮进行灵敏的LC-MS/MS定量分析。

Katekar, Roshan; Wang, Zhengqiang; Xie, Jiashu

Intranasal Delivery of Metabolically Resilient Glutathione: In Vivo Pharmacokinetic, Permeation, and Efficacy Studies

经鼻内途径递送代谢耐受性谷胱甘肽:体内药代动力学、渗透性和疗效研究

Bhilare, Kiran D; Dobariya, Prakashkumar; Lee, Antonio; Xie, Wei; Xie, Jiashu; Meints, Joyce; Vince, Robert; Lee, Michael K; More, Swati S

Norditerpene Natural Products from Subterranean Fungi with Anti-Parasitic Activity

具有抗寄生虫活性的地下真菌来源的北二萜类天然产物

Kolas, Alexandra; Rusman, Yudi; Maia, Ana C R G; Williams, Jessica M; Xie, Jiashu; Katekar, Roshan; Fumuso, Fernanda G; Cotto-Rosario, Alexis; Onoh, Chidiebere N; Baggar, Hanen; Piaskowski, Mary L; Baigorria, Christian; Paes, Raphaella; Chakrabarti, Debopam; Weible, Lyssa J; Ojo, Kayode K; O'Connor, Roberta M; Salomon, Christine E

Design, synthesis and profiling of highly potent antivirals targeting emerging drug-resistant HIV-1 variants

针对新出现的耐药性HIV-1变异株的高效抗病毒药物的设计、合成和分析

Jamey, Nicolas; Udayanga, D M Nirosh; Zhang, Huanchun; Ravichandran, Shreya M; Cai, Xinyong; Lorson, Zachary C; McFadden, William M; Ryu, Won Hee; Katekar, Roshan; Xie, Jiashu; Kirby, Karen A; Sarafianos, Stefan G; Wang, Zhengqiang

Discovery and Characterization of a Hydroxypyridone-3-carboxamide Analog as an Antiviral Lead against Orthopoxviruses

发现并表征羟基吡啶酮-3-甲酰胺类似物作为抗正痘病毒的先导化合物

Pant, Anil; Jagtap, Ajit; Xie, Jiashu; Belhaouari, Djamal Brahim; Xie, Wei; Mahoney, Jacob P; Dsouza, Lara; Wang, Ziyue; Aboezz, Zeinab R; Farkas, Tibor; Wang, Zhengqiang; Yang, Zhilong

Modulation of endogenous opioid signaling by inhibitors of puromycin-sensitive aminopeptidase.

嘌呤霉素敏感氨肽酶抑制剂对内源性阿片信号传导的调节

Singh Rohit, Jiang Rongrong, Williams Jessica, Dobariya Prakashkumar, Hanak Filip, Xie Jiashu, Rothwell Patrick E, Vince Robert, More Swati S

Can remdesivir and its parent nucleoside GS-441524 be potential oral drugs? An in vitro and in vivo DMPK assessment

瑞德西韦及其母体核苷类化合物GS-441524能否成为潜在的口服药物?一项体外和体内DMPK评估

Xie, Jiashu; Wang, Zhengqiang

Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability.

靶向 HIV-1 衣壳蛋白的新型 PF74 样小分子:效力和代谢稳定性的平衡

Wang Lei, Casey Mary C, Vernekar Sanjeev Kumar V, Sahani Rajkumar Lalji, Kirby Karen A, Du Haijuan, Zhang Huanchun, Tedbury Philip R, Xie Jiashu, Sarafianos Stefan G, Wang Zhengqiang

Potency and metabolic stability: a molecular hybrid case in the design of novel PF74-like small molecules targeting HIV-1 capsid protein.

效力和代谢稳定性:针对 HIV-1 衣壳蛋白的新型 PF74 样小分子设计中的分子混合案例

Sahani Rajkumar Lalji, Akther Thamina, Cilento Maria E, Castaner Andres Emanuelli, Zhang Huanchun, Kirby Karen A, Xie Jiashu, Sarafianos Stefan G, Wang Zhengqiang