Repurposing of phosphodiesterase-5 inhibitor sildenafil as a therapeutic agent to prevent gastric cancer growth through suppressing c-MYC stability for IL-6 transcription.
将磷酸二酯酶-5抑制剂西地那非重新用于治疗,通过抑制c-MYC稳定性来抑制IL-6转录,从而预防胃癌的生长
期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-025-07519-9
Zhang Zhenzhan, Huang Wuqing, Huang Donghua, Xu Zhou, Xie Qingfeng, Tan Xin, He Wenjun, Yang Weihao, Li Guoxin, Ji Jianguang, Liu Hao