日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target

天然产物介导的反应劫持机制证实了疟原虫天冬氨酰tRNA合成酶作为抗疟药物靶点的有效性

Ketprasit, Nutpakal; Tai, Chia-Wei; Sharma, Vivek Kumar; Manickam, Yogavel; Khandokar, Yogesh; Ye, Xi; Dogovski, Con; Hilko, David H; Morton, Craig J; Braun, Anne-Sophie C; Leeming, Michael G; Siddharam, Bagale; Shami, Gerald J; Pradeepkumar, Pushpangadan Indira; Panjikar, Santosh; Poulsen, Sally-Ann; Griffin, Michael D W; Sharma, Amit; Tilley, Leann; Xie, Stanley C

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.

一种强效且选择性的恶性疟原虫酪氨酸 tRNA 合成酶反应劫持抑制剂在体内表现出单剂量口服疗效

Xie Stanley C, Tai Chia-Wei, Morton Craig J, Ma Liting, Huang Shih-Chung, Wittlin Sergio, Du Yawei, Hu Yongbo, Dogovski Con, Salimimarand Mina, Griffin Robert, England Dylan, de la Cruz Elisa, Deni Ioanna, Yeo Tomas, Burkhard Anna Y, Striepen Josefine, Schindler Kyra A, Crespo Benigno, Gamo Francisco J, Khandokar Yogesh, Hutton Craig A, Rabie Tayla, Birkholtz Lyn-Marié, Famodimu Mufuliat T, Delves Michael J, Bolsher Judith, Koolen Karin M J, van der Laak Rianne, Aguiar Anna C C, Pereira Dhelio B, Guido Rafael V C, Creek Darren J, Fidock David A, Dick Lawrence R, Brand Stephen L, Gould Alexandra E, Langston Steven, Griffin Michael D W, Tilley Leann

Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase

恶性疟原虫天冬酰胺tRNA合成酶的反应劫持抑制

Xie, Stanley C; Wang, Yinuo; Morton, Craig J; Metcalfe, Riley D; Dogovski, Con; Pasaje, Charisse Flerida A; Dunn, Elyse; Luth, Madeline R; Kumpornsin, Krittikorn; Istvan, Eva S; Park, Joon Sung; Fairhurst, Kate J; Ketprasit, Nutpakal; Yeo, Tomas; Yildirim, Okan; Bhebhe, Mathamsanqa N; Klug, Dana M; Rutledge, Peter J; Godoy, Luiz C; Dey, Sumanta; De Souza, Mariana Laureano; Siqueira-Neto, Jair L; Du, Yawei; Puhalovich, Tanya; Amini, Mona; Shami, Gerry; Loesbanluechai, Duangkamon; Nie, Shuai; Williamson, Nicholas; Jana, Gouranga P; Maity, Bikash C; Thomson, Patrick; Foley, Thomas; Tan, Derek S; Niles, Jacquin C; Han, Byung Woo; Goldberg, Daniel E; Burrows, Jeremy; Fidock, David A; Lee, Marcus C S; Winzeler, Elizabeth A; Griffin, Michael D W; Todd, Matthew H; Tilley, Leann

Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy

酪氨酸tRNA合成酶的反应劫持作为一种新的全生命周期抗疟策略

Xie, Stanley C; Metcalfe, Riley D; Dunn, Elyse; Morton, Craig J; Huang, Shih-Chung; Puhalovich, Tanya; Du, Yawei; Wittlin, Sergio; Nie, Shuai; Luth, Madeline R; Ma, Liting; Kim, Mi-Sook; Pasaje, Charisse Flerida A; Kumpornsin, Krittikorn; Giannangelo, Carlo; Houghton, Fiona J; Churchyard, Alisje; Famodimu, Mufuliat T; Barry, Daniel C; Gillett, David L; Dey, Sumanta; Kosasih, Clara C; Newman, William; Niles, Jacquin C; Lee, Marcus C S; Baum, Jake; Ottilie, Sabine; Winzeler, Elizabeth A; Creek, Darren J; Williamson, Nicholas; Parker, Michael W; Brand, Stephen; Langston, Steven P; Dick, Lawrence R; Griffin, Michael D W; Gould, Alexandra E; Tilley, Leann

Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome

设计对恶性疟原虫具有体内口服疗效且对人蛋白酶体具有选择性的蛋白酶体抑制剂

Xie, Stanley C; Metcalfe, Riley D; Mizutani, Hirotake; Puhalovich, Tanya; Hanssen, Eric; Morton, Craig J; Du, Yawei; Dogovski, Con; Huang, Shih-Chung; Ciavarri, Jeffrey; Hales, Paul; Griffin, Robert J; Cohen, Lawrence H; Chuang, Bei-Ching; Wittlin, Sergio; Deni, Ioanna; Yeo, Tomas; Ward, Kurt E; Barry, Daniel C; Liu, Boyin; Gillett, David L; Crespo-Fernandez, Benigno F; Ottilie, Sabine; Mittal, Nimisha; Churchyard, Alisje; Ferguson, Daniel; Aguiar, Anna Caroline C; Guido, Rafael V C; Baum, Jake; Hanson, Kirsten K; Winzeler, Elizabeth A; Gamo, Francisco-Javier; Fidock, David A; Baud, Delphine; Parker, Michael W; Brand, Stephen; Dick, Lawrence R; Griffin, Michael D W; Gould, Alexandra E; Tilley, Leann

A Dynamic Stress Model Explains the Delayed Drug Effect in Artemisinin Treatment of Plasmodium falciparum

动态应激模型解释了青蒿素治疗恶性疟原虫的延迟药物效应

Cao, Pengxing; Klonis, Nectarios; Zaloumis, Sophie; Dogovski, Con; Xie, Stanley C; Saralamba, Sompob; White, Lisa J; Fowkes, Freya J I; Tilley, Leann; Simpson, Julie A; McCaw, James M

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains

合成臭氧化物抗疟药和双氢青蒿素对K13野生型和突变型恶性疟原虫株活性的暴露时间依赖性比较

Yang, Tuo; Xie, Stanley C; Cao, Pengxing; Giannangelo, Carlo; McCaw, James; Creek, Darren J; Charman, Susan A; Klonis, Nectarios; Tilley, Leann

Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins

血红蛋白降解是早期环状疟原虫对青蒿素敏感的根本原因。

Xie, Stanley C; Dogovski, Con; Hanssen, Eric; Chiu, Francis; Yang, Tuo; Crespo, Maria P; Stafford, Che; Batinovic, Steven; Teguh, Silvia; Charman, Susan; Klonis, Nectarios; Tilley, Leann

Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance

靶向恶性疟原虫的细胞应激反应以克服青蒿素耐药性

Dogovski, Con; Xie, Stanley C; Burgio, Gaetan; Bridgford, Jess; Mok, Sachel; McCaw, James M; Chotivanich, Kesinee; Kenny, Shannon; Gnädig, Nina; Straimer, Judith; Bozdech, Zbynek; Fidock, David A; Simpson, Julie A; Dondorp, Arjen M; Foote, Simon; Klonis, Nectarios; Tilley, Leann

Altered temporal response of malaria parasites determines differential sensitivity to artemisinin

疟原虫时间反应的改变决定了其对青蒿素的敏感性差异

Klonis, Nectarios; Xie, Stanley C; McCaw, James M; Crespo-Ortiz, Maria P; Zaloumis, Sophie G; Simpson, Julie A; Tilley, Leann