PIK3CA mutant cervical cancer is selectively suppressed by PI3Kα inhibition (Alpelisib/BYL-719 and Inavolisib/GDC-0077) and cooperates with HPV directed T cell therapy
PIK3CA突变型宫颈癌可被PI3Kα抑制剂(Alpelisib/BYL-719和Inavolisib/GDC-0077)选择性抑制,并与HPV靶向T细胞疗法协同作用。
期刊:Neoplasia
影响因子:7.7
doi:10.1016/j.neo.2026.101305
Lou, Hong; Langan, David; Syracuse, Nick; Murphy, Elisabeth A; Kim, Sojung; Robinson, Emma; Rossi, Nicole M; Xie, Yi; Tulsyan, Sonam; Joe, Tawnjerae; Rodriguez, Isabel; Rao, Nina; Oberley, Matthew R; Oelke, Mathias; Dean, Michael
肿瘤
T细胞
肿瘤免疫
宫颈癌
T细胞
细胞生物学
免疫/内分泌