Paroxetine repurposing enhances antitumor immunity via SPOP-mediated PD-L1 ubiquitination and proteasomal degradation
帕罗西汀的重新定位通过SPOP介导的PD-L1泛素化和蛋白酶体降解增强抗肿瘤免疫力。
期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-026-03648-z
Xu, Mengting; Tian, Saisai; Xu, Hanchi; Xue, Xinying; Zhang, Qing; Hu, Hongmei; Wu, Gaosong; Geng, Xiangxin; Yu, Dianping; Xu, Hanchen; Xie, Mei; Li, Linyang; Li, Xinru; Li, Simeng; Xie, Shize; Lin, Xuwen; Lyu, Shuzhen; Xie, Yutong; Zhang, Biao; Zhou, Haiyang; Wang, Qun; Zhang, Weidong; Liu, Sanhong
肿瘤
表观遗传
肿瘤免疫
泛素化
SPOP
PD-L1
免疫/内分泌
