日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

GLP-1RA may open a new era for MASLD treatment: Editorial on "Glucagon-like peptide 1 receptor agonist and reduced liver and non-liver complications in adults with type 2 diabetes and metabolic dysfunction-associated steatotic liver disease: a target trial emulation study"

GLP-1RA 或将开启 MASLD 治疗的新纪元：社论《胰高血糖素样肽-1 受体激动剂可减少 2 型糖尿病合并代谢功能障碍相关脂肪肝成人患者的肝脏和非肝脏并发症：一项目标试验模拟研究》

期刊:Clinical and Molecular Hepatology
影响因子:16.9
doi:10.3350/cmh.2025.0628
Feng, Ye; Xu, Chengfu
信号转导
代谢
GLP-1
脂肪肝
糖尿病
发表日期：2026
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NRF1 is upregulated by docosahexaenoic acid to ameliorate MASH through the inhibition of ER stress

二十二碳六烯酸上调NRF1，通过抑制内质网应激来改善MASH。

期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-08139-1
Lin, Mengchi; Zhang, Hongtao; Chen, Shuai; Zhang, Jie; Tang, Chenxi; Song, Xin; Zhou, Jiaming; Xu, Zixin; Mu, Yali; Zeng, Hang; Yang, Changqing; Yu, Chaohui; Xu, Chengfu
内质网应激
发表日期：2026
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Histidine triad nucleotide-binding protein 2 attenuates metabolic dysfunction-associated steatotic liver disease through NAD(+)-dependent sirtuin-3 activation

组氨酸三联体核苷酸结合蛋白2通过NAD(+)依赖性sirtuin-3激活来减轻代谢功能障碍相关的脂肪肝疾病。

期刊:Experimental and Molecular Medicine
影响因子:12.9
doi:10.1038/s12276-025-01445-w
Wang, Qinqiu; Guo, Yanjun; Chen, Shenghui; Liu, Zhening; Wang, Xinyu; Huang, Hangkai; Shen, Qi-En; Yang, Ling; Li, Meng; Li, Youming; Yu, Chaohui; Xu, Chengfu
脂肪肝
代谢
发表日期：2025
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The deubiquitinase USP28 maintains the expression of PPARγ and its inactivation protects mice from diet-induced MASH and hepatocarcinoma

去泛素化酶USP28维持PPARγ的表达，其失活可保护小鼠免受饮食诱导的MASH和肝癌的侵害。

期刊:Molecular Therapy
影响因子:12
doi:10.1016/j.ymthe.2025.01.046
Cai, Changzhou; Luo, Hangqi; Peng, Jin; Zhen, Xinghua; Shen, Xiang; Xi, Xiaomei; Zhu, Jianrong; Fang, Yanfei; Chen, Xiaoli; Wang, Jiewei; Yu, Chaohui; Zhang, Pumin; Xu, Chengfu
肿瘤
表观遗传
肿瘤免疫
泛素化
肝癌
USP28
发表日期：2025
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Tetrahedral framework nucleic acids ameliorate cholestatic liver disease by activating Wnt/β-catenin signaling and promoting ERK1/2 phosphorylation.

四面体框架核酸通过激活 Wnt/β-catenin 信号通路和促进 ERK1/2 磷酸化来改善胆汁淤积性肝病

期刊:Regenerative Biomaterials
影响因子:8.1
doi:10.1093/rb/rbaf017
Zhou Jiaming, Tang Chenxi, Song Xin, Wang Yating, Lin Bingru, Lin Mengchi, Xu Zixin, Lin Shihua, Xu Chengfu, Yu Chaohui
信号转导
MAPK/ERK
磷酸化
发表日期：2025
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Laparoscopically confirmed endometriosis and the risk of incident NAFLD: a prospective cohort study

腹腔镜确诊的子宫内膜异位症与新发非酒精性脂肪性肝病风险：一项前瞻性队列研究

期刊:Reproductive Biology and Endocrinology
影响因子:4.7
doi:10.1186/s12958-025-01391-2
Huang, Hangkai; Liu, Zhening; Ruan, Jiaqi; Fang, Zejun; Xu, Chengfu
脂肪肝
发表日期：2025
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Microbial changes resulting from VSG attenuate MASLD by modulating bile acid metabolism and the intestinal FXR-FGF19 axis

VSG术后引起的肠道菌群变化可通过调节胆汁酸代谢和肠道FXR-FGF19轴来减轻MASLD。

期刊:mSystems
影响因子:4.6
doi:10.1128/msystems.00634-25
Xia, Yi; Yang, Jinpu; Lu, Shixian; Cheng, Weixin; Ren, Mengting; Liu, Zhening; Yang, Ling; Shen, Qien; Liang, Yujie; Huang, Hangkai; Chen, Minjie; Zhou, Xinxin; Yu, Mosang; Ji, Feng; Xu, Chengfu
FGF1
代谢
微生物学
肠道菌群
FGF19
发表日期：2025
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Amyloid precursor protein promotes MASH progression by upregulating death receptor 6-mediated hepatocyte apoptosis

淀粉样前体蛋白通过上调死亡受体6介导的肝细胞凋亡来促进MASH的进展

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2025.108285
Guo, Yanjun; Huang, Hangkai; Yang, Ling; Shen, Qien; Liu, Zhening; Wang, Qinqiu; Chen, Shenghui; Pan, Jiaqi; Zhai, Haoliang; Li, Youming; Xu, Lei; Yu, Chaohui; Xu, Chengfu
信号转导
细胞生物学
凋亡
表观遗传
发表日期：2025
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Remnant cholesterol predicts the development of type 2 diabetes in patients with nonalcoholic fatty liver disease

残余胆固醇可预测非酒精性脂肪肝患者发生2型糖尿病的风险。

期刊:Diabetology & Metabolic Syndrome
影响因子:3.9
doi:10.1186/s13098-025-01828-z
Yang, Liping; Huang, Hangkai; Wang, Zejun; Xu, Chengfu
糖尿病
脂肪肝
代谢
发表日期：2025
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High uric acid exacerbates nonalcoholic steatohepatitis through NLRP3 inflammasome and gasdermin D-mediated pyroptosis.

高尿酸通过 NLRP3 炎症小体和 gasdermin D 介导的细胞焦亡加剧非酒精性脂肪性肝炎

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2025.110249
Xu Zixin, Tang Chenxi, Song Xin, Liu Zhening, Zhou Jiaming, Shi Qiaojuan, Yu Chaohui, Xu Chengfu
细胞生物学
炎性小体
炎症
焦亡
发表日期：2025
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