Targeted NAT10 Degradation by PROTAC NP1192 Suppresses Hypoxia-Adaptive Glycolysis and Reinvigorates CD8(+) Effector T‑Cell Function for Synergistic Cancer Immunotherapy
PROTAC NP1192靶向降解NAT10可抑制缺氧适应性糖酵解,并重新激活CD8(+)效应T细胞功能,从而实现协同癌症免疫治疗。
期刊:ACS Central Science
影响因子:10.4
doi:10.1021/acscentsci.5c00812
Ao, Keyi; Sun, Zhiqiang; Hao, Yi; Qin, Jiaqi; Xu, Chenglong; Wen, Xiuli; Yang, Zichao; Li, Li; Gan, Shaoyan; Chen, Xiaona; Li, Xin; Zhang, Jian; Chen, Jianjun; Guo, Xia
NAT10
肿瘤
T细胞
肿瘤免疫
CD8
T细胞
细胞生物学
免疫/内分泌