Methotrexate-triggered ferroptosis suppresses oral cancer progression by phosphorylated KEAP1-mediated NRF2 degradation to inhibit SLC7A11/GPX4 signaling pathway.
甲氨蝶呤触发的铁死亡通过磷酸化 KEAP1 介导的 NRF2 降解来抑制 SLC7A11/GPX4 信号通路,从而抑制口腔癌的进展。
期刊:Cancer Cell International
影响因子:6
doi:10.1186/s12935-025-04019-y
Yu Chenchen, Zhang Tingting, Yuan Jialu, Su Yijing, Zhang Hongli, Xu Liqin, Li Xiaomin, Cui Jianan, Xu Rui, Zhou Yan, Huang Hongming, Zhou Xiaorong, Zhou Yongqiang, Zhang Erhao
口腔癌
信号转导
GPX4
NRF2
KEAP1
磷酸化
铁死亡