日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rapidly acquired HIV-1 neutralization breadth in a rhesus V2 apex knockin mouse model after a single bolus immunization

单次注射免疫后,恒河猴V2顶端敲入小鼠模型迅速获得HIV-1中和广度

Ghosh, Amrit Raj; Habib, Rumi; Mishra, Nitesh; Roark, Ryan S; Akauliya, Madhav; Albowaidey, Ali A; Allen, Joel D; Amereh, Khaled; Avillion, Gabriel; Bottermann, Maria; Liang, Bo; Chaudhary, Namit; Callaghan, Sean; Dye, Jonathan; Li, Xuduo; Ellis-Pugh, Jordan R; Roy Chowdhury, Rohan; James, Nicole E; Liu, Xiaotie; Maiorino, Laura; Villavicencio, Paula M; Nedellec, Rebecca; Oberoi, Prabhgun; Sowers, Kirsten J; Park, Younghoon; Prum, Thavaleak; Rodriguez, Linette; Ssozi, Maria; Torres, Jonathan L; Walsh, Agnes A; Warner, John E; Weldon, Stephanie R; Xu, Liling; Wiehe, Kevin; Crispin, Max; Ward, Andrew B; Nair, Usha; Hahn, Beatrice H; Burton, Dennis R; Shapiro, Lawrence; Kwong, Peter D; Irvine, Darrell J; Andrabi, Raiees; Shaw, George M; Batista, Facundo D

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development.

Env抗体共同进化表明B细胞启动是HIV V2顶端广泛中和抗体发展的主要瓶颈。

Habib Rumi, Roark Ryan S, Li Hui, Connell Andrew Jesse, Hogarty Michael P, Wagh Kshitij, Wang Shuyi, Marchitto Lorie, Skelly Ashwin N, Carey John W, Sowers Kirsten J, Ayyanathan Kasirajan, Plante Samantha J, Bibollet-Ruche Frederic, Park Younghoon, Agostino Colby J, Singh Ajay, Martella Christian L, Lewis Emily, Rando Juliette M, Chohan Neha, Lora Jinery, Ding Wenge, Campion Mary S, Zhao Chengyan, Liu Weimin, Li Yingying, Li Xuduo, Liang Bo, Chowdhury Rohan Roy, Amereh Khaled, Van Itallie Elizabeth, Sheng Zizhang, Ghosh Amrit R, Bar Katharine J, Williams Wilton B, Wiehe Kevin, Saunders Kevin O, Edwards Robert J, Cain Derek W, Lewis Mark G, Batista Facundo D, Burton Dennis R, Andrabi Raiees, Kulp Daniel W, Haynes Barton F, Korber Bette, Shapiro Lawrence, Kwong Peter D, Hahn Beatrice H, Shaw George M

Early clonal dominance at priming sets the trajectory for broad HIV serum neutralization.

早期克隆优势决定了 HIV 血清中和的广泛进程。

Liang Bo, Zhu Yuxin, Roark Ryan S, Li Xuduo, Mishra Nitesh, Martella Christian L, Vo Anh L, Giese Gabriella, Huang Qin, Biju Andrea, Tjio Lifei, Chowdhury Rohan Roy, Oberoi Prabhgun, Amereh Khaled, Wani Areeba A, Zhang Yuexiu, Andrabi Sharaf, Sekar Tharunika V, Somanathan Anjali, Kassab Muzaffer, Nedellec Rebecca, Callaghan Sean, Avillion Gabriel, Lewis Mark G, Sackett Sara Dutton, Skelly Ashwin N, Bibollet-Ruche Frederic, Shapiro Lawrence, Sheng Zizhang, Briney Bryan, Hahn Beatrice H, Burton Dennis R, Irvine Darrell J, Kwong Peter D, Shaw George M, Andrabi Raiees

Heterologous betacoronavirus spike immunization in nonhuman primates elicits cross-reactive antibodies that neutralize both sarbeco- and merbecoviruses.

在非人灵长类动物中进行异源β冠状病毒刺突蛋白免疫可诱导产生交叉反应抗体,该抗体可中和沙贝病毒和默贝病毒。

Dueker Katharina, Capozzola Tazio, Feng Ziqi, Lin Ryan N, Hurtado Jonathan, Bangaru Sandhya, Yuan Meng, Beutler Nathan, Garcia Elijah, He Wan-Ting, Callaghan Sean, Avillion Gabriel, Vo Lina, Li Xuduo, Torres Jonathan L, Musharrafieh Rami, Song Ge, Mishra Nitesh, Sharma Pragati, Yong Peter, Anzanello Fabio, Kaczmarek-Michaels Kasia, Ben-Akiva Elana, Silva Murillo, Melo Mariane, Makhdoomi Muzamil, Westfall-Gomez Ethan, Rinaldi William, Ferguson Melissa, Safonova Yana, Crotty Shane, Irvine Darrell J, Rogers Thomas, Ward Andrew B, Briney Bryan, Wilson Ian A, Burton Dennis R, Andrabi Raiees

Molecular parameters governing antibody FcγR signaling and effector functions in the context of HIV envelope

HIV包膜蛋白背景下调控抗体FcγR信号传导和效应功能的分子参数

Bick, Michael V; Puig, Eduard; Beauparlant, David; Nedellec, Rebecca; Burton, Iszac; Ardaghi, Keihvan; Zalunardo, Thea R; Bastidas, Raiza; Li, Xuduo; Guenaga, Javier; Lee, Wen-Hsin; Wyatt, Richard; Zhu, Wenwen; Crispin, Max; Ozorowski, Gabriel; Ward, Andrew B; Burton, Dennis R; Hangartner, Lars

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development

Env抗体协同进化研究表明,B细胞启动是HIV-1 V2顶端广谱中和抗体产生的主要瓶颈。

Habib, Rumi; Roark, Ryan S; Li, Hui; Connell, Andrew Jesse; Hogarty, Michael P; Wagh, Kshitij; Wang, Shuyi; Marchitto, Lorie; Skelly, Ashwin N; Carey, John W; Sowers, Kirsten J; Ayyanathan, Kasirajan; Plante, Samantha J; Bibollet-Ruche, Frederic; Park, Younghoon; Agostino, Colby J; Singh, Ajay; Martella, Christian L; Lewis, Emily; Rando, Juliette M; Chohan, Neha; Lora, Jinery; Ding, Wenge; Campion, Mary S; Zhao, Chengyan; Liu, Weimin; Li, Yingying; Li, Xuduo; Liang, Bo; Chowdhury, Rohan Roy; Amereh, Khaled; Van Itallie, Elizabeth; Sheng, Zizhang; Ghosh, Amrit R; Bar, Katharine J; Williams, Wilton B; Wiehe, Kevin; Saunders, Kevin O; Edwards, Robert J; Cain, Derek W; Lewis, Mark; Batista, Facundo D; Burton, Dennis R; Andrabi, Raiees; Kulp, Daniel W; Haynes, Barton F; Korber, Bette; Shapiro, Lawrence; Kwong, Peter D; Hahn, Beatrice H; Shaw, George M

Structure-guided design of native-like HIV Env Single Chain Trimers for enhanced stability, immunogenicity, and versatile vaccine delivery

以结构为导向设计天然样HIV Env单链三聚体,以增强其稳定性、免疫原性和多功能疫苗递送系统

Li, Xuduo; Krishnamurthy, Ipsita; Mishra, Nitesh; James, Nicole E; Chowdhury, Rohan Roy; Callaghan, Sean; Somanathan, Anjali; Avillion, Gabriel; Amereh, Khaled; Sekar, Tharunika; Oberoi, Prabhgun; Zhu, Yuxin; Torres, Jonathan L; Lee, Wen-Hsin; Allen, Joel D; Liang, Bo; Giese, Gabriella; Vo, Anh L; Andrabi, Sharaf; Jain, Ishita; Mergiya, Asanti; Capozzola, Tazio; He, Wan-Ting; Anzanello, Fabio; Habib, Rumi; Bibollet-Ruche, Frederic; Nedellec, Rebecca; Sackett, Sara Dutton; Ozorowski, Gabriel; Burton, Dennis R; Hahn, Beatrice H; Shaw, George M; Ward, Andrew B; Crispin, Max; Barnes, Christopher O; Andrabi, Raiees

Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design

通过一种新型两步机制持续诱导广谱中和HIV抗体,为免疫原设计提供指导

Skelly, Ashwin N; Gristick, Harry B; Li, Hui; Gavor, Edem; Connell, Andrew J; Kreider, Edward F; Marchitto, Lorie; Hogarty, Michael P; Newby, Maddy L; Allen, Joel D; Liu, Weimin; West, Anthony P Jr; Ayyanathan, Kasirajan; Campion, Mary S; Winters, Kaitlyn; Gordon, Colette G; Osbaldeston, Rebecca A; Akeley, Macy J; Li, Yingying; Singh, Ajay; Cruickshank, Kendra; Park, Younghoon; Zhao, Chengyan; Li, Xuduo; Amereh, Khaled; Itallie, Elizabeth Van; Carey, John W; Albertus, Amie; DeLaitsch, Andrew T; Keeffe, Jennifer R; Lituchy, Melinda G; Walsh, Agnes A; Morris, Daniel J; Habib, Rumi; Bibollet-Ruche, Frederic; Mishra, Nitesh; Avillion, Gabriel; Koranda, Nicholas S; Plante, Samantha J; Martella, Christian L; Lora, Jinery; Wang, Eric J D; Lewis, Mark G; Martin, Malcolm A; Nussenzweig, Michel C; Seaman, Michael S; Irvine, Darrell J; Wiehe, Kevin J; Haynes, Barton F; Wagh, Kshitij; Korber, Bette T; Andrabi, Raiees; Crispin, Max; Weissman, Drew; Bjorkman, Pamela J; Hahn, Beatrice H; Shaw, George M

Directed evolution of a stem-helix-targeting antibody enables MERS-CoV cross-neutralization through enhanced binding affinity.

通过定向进化,靶向茎螺旋结构的抗体能够增强结合亲和力,从而实现对MERS-CoV的交叉中和。

Zhou Panpan, Yuan Meng, Zhang Yuexiu, Limbo Oliver, Song Ge, Zhao Fangzhu, Liu Hejun, He Wan-Ting, Capozzola Tazio, Callaghan Sean, Avillion Gabriel, Li Xuduo, Beutler Nathan, Yong Peter, Anzanello Fabio, Rogers Thomas F, Burton Dennis R, Jardine Joseph G, Wilson Ian A, Andrabi Raiees

Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques.

针对种系 HIV 免疫原的免疫原可诱导非近交系猕猴产生交叉中和抗体。

Mishra Nitesh, Liang Bo, Roark Ryan S, Ghosh Amrit, Callaghan Sean, Lee Wen-Hsin, Li Xuduo, Vo Anh L, Avillion Gabriel, Chowdhury Rohan Roy, Habib Rumi H, Bibollet-Ruche Frederic, Giese Gabriella, Oberoi Prabhgun, Amereh Khaled, Somanathan Anjali, Zhu Yuxin, Zhang Yuexiu, Kassab Muzaffer, Tjio Lifei, Andrabi Sharaf, Reyes Raphael A, Allen Joel D, James Nicole E, Randall Kipchoge N Jr, van der Maas Lara, Ben-Akiva Elana, Kacmarek-Michaels Kasia, Plante Samantha, Martella Christian L, Skelly Ashwin N, Singh Ajay, Hurtado Jonathan, Dueker Katharina, Capozzola Tazio, Nedellec Rebecca, Ozorowski Gabriel, Lewis Mark M, Falcone Samantha, Carfi Andrea, Himansu Sunny, Shapiro Lawrence, Crispin Max, Hahn Beatrice H, Briney Bryan, Irvine Darrell J, Burton Dennis R, Ward Andrew B, Batista Facundo D, Kwong Peter D, Shaw George M, Andrabi Raiees