日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Accurate strand-specific long-read transcript isoform discovery and quantification at bulk, single-cell, and single-nucleus resolution.

在整体、单细胞和单核分辨率下,精确地发现和定量链特异性长读转录本异构体。

Yu Houlin, Georgescu Christophe H, Khorgade Akanksha, Al-Eryani Ghamdan, Bartlett Daniel A, Brookhart Allison, Kockan Can, Webber James T, Shin Asa, White Emily, Reed Xylena, Hu Fangle, Bromberek Sarah, Ndayambaje Sandra, Aryal Sandeep, Dickson Dennis W, Prudencio Mercedes, Lagier-Tourenne Clotilde, Ward Michael E, Blainey Paul C, Popic Victoria, Haas Brian J, Al'Khafaji Aziz M

Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice.

炎症信号对人类和小鼠的帕金森病相关激酶 LRRK2 的染色质可及性和基因表达的影响存在差异。

Beilina Alexandra, Park Jae-Hyeon, Landeck Natalie, Chia Ruth, Ding Jinhui, Reed Xylena, Bailey Hannah, Kim Changyoun, Kaganovich Alice, Acri Dominic J, Brooks Janet, Mann Alexandra, Zaghloul Kareem A, Marsan Elise, Gibbs J Raphael, DeCasien Alex, Cookson Mark R

Long-Read epigenetic clocks identify improved brain aging predictions

长读长表观遗传时钟可提高大脑衰老预测的准确性

Grant, Spencer M; Makarious, Mary B; Meredith, Melissa; Moller, Abraham; Grant-Peters, Melissa; Hicks, Amy; Mandal, Ajeet; Auluck, Pavan; Leonard, Hampton; Kuznetsov, Nicole; Weller, Cory; Reed, Xylena; Jain, Miten; Ferrucci, Luigi; Cookson, Mark R; Ryten, Mina; Nalls, Mike A; Billingsley, Kimberley J

Haplotype-Resolved DNA Methylation at the APOE Locus identifies Allele-Specific Epigenetic Signatures Relevant to Alzheimer's Disease Risk

基于单倍型解析的APOE基因座DNA甲基化分析揭示了与阿尔茨海默病风险相关的等位基因特异性表观遗传特征。

Genner, Rylee M; Meredith, Melissa; Moller, Abraham; Weller, Cory; Daida, Kensuke; Ayuketah, Alexis; Jerez, Pilar Alvarez; Akeson, Stuart; Malik, Laksh; Baker, Breeana; Kouam, Cedric; Paquette, Kimberly; Marenco, Stefano; Auluck, Pavan; Mandal, Ajeet; Paten, Benedict; Reed, Xylena; Jain, Miten; Cookson, Mark R; Singleton, Andrew B; Nalls, Mike; Blauwendraat, Cornelis; Billingsley, Kimberley J

Characterizing a complex CT-rich haplotype in intron 4 of SNCA using large-scale targeted amplicon long-read sequencing

使用大规模靶向扩增子长读测序鉴定 SNCA 内含子 4 中复杂的富含 CT 的单倍型

Pilar Alvarez Jerez, Kensuke Daida, Francis P Grenn, Laksh Malik, Abigail Miano-Burkhardt, Mary B Makarious, Jinhui Ding, J Raphael Gibbs, Anni Moore, Xylena Reed, Mike A Nalls, Syed Shah, Medhat Mahmoud, Fritz J Sedlazeck, Egor Dolzhenko, Morgan Park, Hirotaka Iwaki, Bradford Casey, Mina Ryten, Cor

A SINE-VNTR-Alu at the LRIG2 locus is associated with proximal and distal gene expression in CRISPR and population models

LRIG2 基因座上的 SINE-VNTR-Alu 与 CRISPR 和群体模型中的近端和远端基因表达相关

Ashley Hall, Ben Middlehurst, Max A M Cadogan, Xylena Reed, Kimberley J Billingsley, Vivien J Bubb, John P Quinn

Characterization of DNA methylation in PBMCs and donor-matched iPSCs shows methylation is reset during stem cell reprogramming

对 PBMC 和供体匹配的 iPSC 中的 DNA 甲基化的表征表明,甲基化在干细胞重编程过程中被重置

Xylena Reed, Cory A Weller, Sara Saez-Atienzar, Alexandra Beilina, Sultana Solaiman, Makayla Portley, Mary Kaileh, Roshni Roy, Jinhui Ding, A Zenobia Moore, D Thad Whitaker, Bryan J Traynor, J Raphael Gibbs, Sonja W Scholz, Mark R Cookson

Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study

非洲及非洲混血人群中帕金森病相关遗传风险位点的鉴定及因果关系研究:一项全基因组关联研究

Rizig, Mie; Bandres-Ciga, Sara; Makarious, Mary B; Ojo, Oluwadamilola Omolara; Crea, Peter Wild; Abiodun, Oladunni Victoria; Levine, Kristin S; Abubakar, Sani Atta; Achoru, Charles Obiora; Vitale, Dan; Adeniji, Olaleye Akinmola; Agabi, Osigwe Paul; Koretsky, Mathew J; Agulanna, Uchechi; Hall, Deborah A; Akinyemi, Rufus Olusola; Xie, Tao; Ali, Mohammed Wulgo; Shamim, Ejaz A; Ani-Osheku, Ifeyinwa; Padmanaban, Mahesh; Arigbodi, Ohwotemu Michael; Standaert, David G; Bello, Abiodun Hamzat; Dean, Marissa N; Erameh, Cyril Oshomah; Elsayed, Inas; Farombi, Temitope Hannah; Okunoye, Olaitan; Fawale, Michael Bimbola; Billingsley, Kimberley J; Imarhiagbe, Frank Aiwansoba; Jerez, Pilar Alvarez; Iwuozo, Emmanuel Uzodinma; Baker, Breeana; Komolafe, Morenikeji Adeyoyin; Malik, Laksh; Nwani, Paul Osemeke; Daida, Kensuke; Nwazor, Ernest Okwundu; Miano-Burkhardt, Abigail; Nyandaiti, Yakub Wilberforce; Fang, Zih-Hua; Obiabo, Yahaya Olugbo; Kluss, Jillian H; Odeniyi, Olanike Adedoyin; Hernandez, Dena G; Odiase, Francis Ehidiamen; Tayebi, Nahid; Ojini, Francis Ibe; Sidranksy, Ellen; Onwuegbuzie, Gerald Awele; D'Souza, Andrea M; Osaigbovo, Godwin Osawaru; Berhe, Bahafta; Osemwegie, Nosakhare; Reed, Xylena; Oshinaike, Olajumoke Olufemi; Leonard, Hampton L; Otubogun, Folajimi Morenikeji; Alvarado, Chelsea X; Oyakhire, Shyngle Imiewan; Ozomma, Simon Izuchukwu; Samuel, Sarah Chabiri; Taiwo, Funmilola Tolulope; Wahab, Kolawole Wasiu; Zubair, Yusuf Agboola; Iwaki, Hirotaka; Kim, Jonggeol Jeffrey; Morris, Huw R; Hardy, John; Nalls, Mike A; Heilbron, Karl; Norcliffe-Kaufmann, Lucy; Blauwendraat, Cornelis; Houlden, Henry; Singleton, Andrew; Okubadejo, Njideka Ulunma

Scalable Nanopore sequencing of human genomes provides a comprehensive view of haplotype-resolved variation and methylation

可扩展的纳米孔测序技术能够对人类基因组进行全面分析,从而揭示单倍型解析的变异和甲基化情况。

Kolmogorov, Mikhail; Billingsley, Kimberley J; Mastoras, Mira; Meredith, Melissa; Monlong, Jean; Lorig-Roach, Ryan; Asri, Mobin; Alvarez Jerez, Pilar; Malik, Laksh; Dewan, Ramita; Reed, Xylena; Genner, Rylee M; Daida, Kensuke; Behera, Sairam; Shafin, Kishwar; Pesout, Trevor; Prabakaran, Jeshuwin; Carnevali, Paolo; Yang, Jianzhi; Rhie, Arang; Scholz, Sonja W; Traynor, Bryan J; Miga, Karen H; Jain, Miten; Timp, Winston; Phillippy, Adam M; Chaisson, Mark; Sedlazeck, Fritz J; Blauwendraat, Cornelis; Paten, Benedict

Inhibition of p38α MAPK restores neuronal p38γ MAPK and ameliorates synaptic degeneration in a mouse model of DLB/PD.

抑制 p38α MAPK 可恢复神经元 p38α MAPK,并改善 DLB/PD 小鼠模型中的突触退化

Iba Michiyo, Kim Changyoun, Kwon Somin, Szabo Marcell, Horan-Portelance Liam, Peer Cody J, Figg William D, Reed Xylena, Ding Jinhui, Lee Seung-Jae, Rissman Robert A, Cookson Mark R, Overk Cassia, Wrasidlo Wolf, Masliah Eliezer