日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combinatorial organoid mutagenesis screen reveals gene constellations driving malignant transformation, pathology and chemosensitivity in high-grade serous ovarian carcinoma

组合类器官诱变筛选揭示了驱动高级别浆液性卵巢癌恶性转化、病理和化疗敏感性的基因组合

Phuong, Daryl J; Ralston, Coulter Q; Ezzat, Tony M; Ashe, Christopher S; Armstrong, Amanda P; Flesken-Nikitin, Andrea; Yamulla, Robert J; Nikitin, Alexander Yu; Schimenti, John C

Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5-CD44+ cells

胃鳞状柱状交界处含有大量易癌变的未成熟骨桥蛋白反应性Lgr5-CD44+细胞。

Dah-Jiun Fu ,Lianghai Wang ,Fouad K Chouairi ,Ian M Rose ,Danysh A Abetov ,Andrew D Miller ,Robert J Yamulla ,John C Schimenti ,Andrea Flesken-Nikitin ,Alexander Yu Nikitin

Most Commonly Mutated Genes in High-Grade Serous Ovarian Carcinoma Are Nonessential for Ovarian Surface Epithelial Stem Cell Transformation

高级别浆液性卵巢癌中最常见的突变基因对于卵巢表面上皮干细胞转化并非必需的

Robert Joseph Yamulla, Shreya Nalubola, Andrea Flesken-Nikitin, Alexander Yu Nikitin, John C Schimenti

The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2

聚(ADP-核糖)聚合酶 Tankyrase 通过 ADP-核糖基化 Axin 和 APC2 来拮抗 β-Catenin 破坏复合物的活性

Heather E Croy, Caitlyn N Fuller, Jemma Giannotti, Paige Robinson, Andrew V A Foley, Robert J Yamulla, Sean Cosgriff, Bradford D Greaves, Ryan A von Kleeck, Hyun Hyung An, Catherine M Powers, Julie K Tran, Aaron M Tocker, Kimberly D Jacob, Beckley K Davis, David M Roberts

Testing models of the APC tumor suppressor/β-catenin interaction reshapes our view of the destruction complex in Wnt signaling

APC 肿瘤抑制因子/β-catenin 相互作用的测试模型重塑了我们对 Wnt 信号破坏复合物的看法

Robert J Yamulla, Eric G Kane, Alexandra E Moody, Kristin A Politi, Nicole E Lock, Andrew V A Foley, David M Roberts