日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

GDF8 and activin A are the key negative regulators of muscle mass in postmenopausal females: a randomized phase I trial

GDF8 和激活素 A 是绝经后女性肌肉量的关键负调控因子:一项随机 I 期试验

Gonzalez Trotter, Dinko; Donahue, Stephen; Wynne, Chris; Ali, Shazia; Parasoglou, Prodromos; Boyapati, Anita; Mohammadi, Kusha; Musser, Bret J; Meier, Pretty; Mastaitis, Jason; Sleeman, Mark W; Glass, David J; Gasparino, Evelyn; Trejos, Jesus; Davis, John D; Hirshberg, Boaz; Pordy, Robert; Yancopoulos, George D; Herman, Gary A

GDF8 and activin A blockade protects against GLP-1-induced muscle loss while enhancing fat loss in obese male mice and non-human primates

GDF8 和激活素 A 阻断可防止 GLP-1 诱导的肥胖雄性小鼠和非人灵长类动物肌肉流失,同时增强脂肪减少。

Mastaitis, Jason W; Gomez, Daniel; Raya, José G; Li, Diana; Min, Soo; Stec, Michael; Kleiner, Sandra; McWilliams, Toya; Altarejos, Judith Y; Murphy, Andrew J; Yancopoulos, George D; Sleeman, Mark W

Evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy disease: an open-label phase 2 and 3 study

评估 pozelimab 在伴有补体过度激活、血管病性血栓形成和蛋白丢失性肠病的 CD55 缺陷患者中的疗效和安全性:一项开放标签的 2 期和 3 期研究

Ozen, Ahmet; Chongsrisawat, Voranush; Sefer, Asena Pinar; Kolukisa, Burcu; Jalbert, Jessica J; Meagher, Karoline A; Brackin, Taylor; Feldman, Hagit Baris; Baris, Safa; Karakoc-Aydiner, Elif; Ergelen, Rabia; Fuss, Ivan J; Moorman, Heather; Suratannon, Narissara; Suphapeetiporn, Kanya; Perlee, Lorah; Harari, Olivier A; Yancopoulos, George D; Lenardo, Michael J

Linvoseltamab for Treatment of Relapsed/Refractory Multiple Myeloma

Linvoseltamab 用于治疗复发/难治性多发性骨髓瘤

Bumma, Naresh; Richter, Joshua; Jagannath, Sundar; Lee, Hans C; Hoffman, James E; Suvannasankha, Attaya; Zonder, Jeffrey A; Shah, Mansi R; Lentzsch, Suzanne; Baz, Rachid; Maly, Joseph J; Namburi, Swathi; Pianko, Matthew J; Ye, Jing Christine; Wu, Ka Lung; Silbermann, Rebecca; Min, Chang-Ki; Vekemans, Marie-Christiane; Munder, Markus; Byun, Ja Min; Martínez-Lopez, Joaquín; Cassady, Kaniel; DeVeaux, Michelle; Chokshi, Dhruti; Boyapati, Anita; Hazra, Anasuya; Yancopoulos, George D; Sirulnik, L Andres; Rodriguez Lorenc, Karen; Kroog, Glenn S; Houvras, Yariv; Dhodapkar, Madhav V

A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies

一种靶向PD-1、受体掩蔽的IL-2免疫细胞因子,可通过与IL-2Rα结合来增强T细胞介导的抗肿瘤疗法。

Jiaxi Wu ,Nicolin Bloch ,Aaron Y Chang ,Ramandeep Bhavsar ,Qingqing Wang ,Alison Crawford ,David J DiLillo ,Kristin Vazzana ,Katja Mohrs ,Drew Dudgeon ,Supriya Patel ,Hassan Ahmed ,Vidur Garg ,Michael Amatulli ,Olivia Q Antao ,Yuetian Yan ,Shunhai Wang ,Willy Ramos ,Pamela Krueger ,Christina Adler ,Min Ni ,Yi Wei ,Chunguang Guo ,Lynn Macdonald ,Tammy Huang ,Erica Ullman ,Aynur Hermann ,George D Yancopoulos ,Andrew J Murphy ,Samuel Davis ,William C Olson ,John C Lin ,Eric Smith ,Tong Zhang

Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials

Dupilumab治疗结节性痒疹患者:两项随机、双盲、安慰剂对照的3期试验

Yosipovitch, Gil; Mollanazar, Nicholas; Ständer, Sonja; Kwatra, Shawn G; Kim, Brian S; Laws, Elizabeth; Mannent, Leda P; Amin, Nikhil; Akinlade, Bolanle; Staudinger, Heribert W; Patel, Naimish; Yancopoulos, George D; Weinreich, David M; Wang, Sheldon; Shi, Genming; Bansal, Ashish; O'Malley, John T

Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial

Garetosmab治疗进行性骨化性纤维发育不良:一项随机、双盲、安慰剂对照的II期试验

Di Rocco, Maja; Forleo-Neto, Eduardo; Pignolo, Robert J; Keen, Richard; Orcel, Philippe; Funck-Brentano, Thomas; Roux, Christian; Kolta, Sami; Madeo, Annalisa; Bubbear, Judith S; Tabarkiewicz, Jacek; Szczepanek, Małgorzata; Bachiller-Corral, Javier; Cheung, Angela M; Dahir, Kathryn M; Botman, Esmée; Raijmakers, Pieter G; Al Mukaddam, Mona; Tile, Lianne; Portal-Celhay, Cynthia; Sarkar, Neena; Hou, Peijie; Musser, Bret J; Boyapati, Anita; Mohammadi, Kusha; Mellis, Scott J; Rankin, Andrew J; Economides, Aris N; Trotter, Dinko Gonzalez; Herman, Gary A; O'Meara, Sarah J; DelGizzi, Richard; Weinreich, David M; Yancopoulos, George D; Eekhoff, E Marelise W; Kaplan, Frederick S

Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM

利用冷冻电镜技术对癌症相关TCR-CD3和肽-MHC复合物进行结构分析

Kei Saotome ,Drew Dudgeon ,Kiersten Colotti ,Michael J Moore ,Jennifer Jones ,Yi Zhou ,Ashique Rafique ,George D Yancopoulos ,Andrew J Murphy ,John C Lin ,William C Olson ,Matthew C Franklin

Structural insights into the assembly of gp130 family cytokine signaling complexes

gp130 家族细胞因子信号复合物组装的结构洞察

Yi Zhou, Panayiotis E Stevis, Jing Cao, Kei Saotome, Jiaxi Wu, Arielle Glatman Zaretsky, Sokol Haxhinasto, George D Yancopoulos, Andrew J Murphy, Mark W Sleeman, William C Olson, Matthew C Franklin

Effect of High-Dose Intravitreal Aflibercept, 8 mg, in Patients With Neovascular Age-Related Macular Degeneration: The Phase 2 CANDELA Randomized Clinical Trial

高剂量玻璃体内注射阿柏西普(8毫克)治疗新生血管性年龄相关性黄斑变性患者的疗效:CANDELA II期随机临床试验

Wykoff, Charles C; Brown, David M; Reed, Kimberly; Berliner, Alyson J; Gerstenblith, Adam T; Breazna, Aurora; Abraham, Prema; Fein, Jordana G; Chu, Karen W; Clark, W Lloyd; Leal, Sergio; Schmelter, Thomas; Hirshberg, Boaz; Yancopoulos, George D; Vitti, Robert