日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Humans with function-disrupting variants in the myostatin gene (MSTN) have increased skeletal muscle mass and strength, and less adiposity

携带破坏肌肉生长抑制素基因(MSTN)功能变异的人类,其骨骼肌质量和力量增加,脂肪含量减少。

Herman, Joseph L; Dornbos, Peter; Landheer, Karl; Geraghty, Benjamin J; Egerman, Marc A; Phan, Duc; Germino, Mary; Mastaitis, Jason W; Walls, Johnathon R; Lotta, Luca A; Abecasis, Gonçalo; Baras, Aris; Altarejos, Judith Y; Sleeman, Mark W; Melander, Olle; Shavlakadze, Tea; Yancopoulos, George D; Bovijn, Jonas; Marchini, Jonathan; Glass, David J

GDF8 and activin A are the key negative regulators of muscle mass in postmenopausal females: a randomized phase I trial

GDF8 和激活素 A 是绝经后女性肌肉量的关键负调控因子:一项随机 I 期试验

Gonzalez Trotter, Dinko; Donahue, Stephen; Wynne, Chris; Ali, Shazia; Parasoglou, Prodromos; Boyapati, Anita; Mohammadi, Kusha; Musser, Bret J; Meier, Pretty; Mastaitis, Jason; Sleeman, Mark W; Glass, David J; Gasparino, Evelyn; Trejos, Jesus; Davis, John D; Hirshberg, Boaz; Pordy, Robert; Yancopoulos, George D; Herman, Gary A

GDF8 and activin A blockade protects against GLP-1-induced muscle loss while enhancing fat loss in obese male mice and non-human primates

GDF8 和激活素 A 阻断可防止 GLP-1 诱导的肥胖雄性小鼠和非人灵长类动物肌肉流失,同时增强脂肪减少。

Mastaitis, Jason W; Gomez, Daniel; Raya, José G; Li, Diana; Min, Soo; Stec, Michael; Kleiner, Sandra; McWilliams, Toya; Altarejos, Judith Y; Murphy, Andrew J; Yancopoulos, George D; Sleeman, Mark W

Evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy disease: an open-label phase 2 and 3 study

评估 pozelimab 在伴有补体过度激活、血管病性血栓形成和蛋白丢失性肠病的 CD55 缺陷患者中的疗效和安全性:一项开放标签的 2 期和 3 期研究

Ozen, Ahmet; Chongsrisawat, Voranush; Sefer, Asena Pinar; Kolukisa, Burcu; Jalbert, Jessica J; Meagher, Karoline A; Brackin, Taylor; Feldman, Hagit Baris; Baris, Safa; Karakoc-Aydiner, Elif; Ergelen, Rabia; Fuss, Ivan J; Moorman, Heather; Suratannon, Narissara; Suphapeetiporn, Kanya; Perlee, Lorah; Harari, Olivier A; Yancopoulos, George D; Lenardo, Michael J

Linvoseltamab for Treatment of Relapsed/Refractory Multiple Myeloma

Linvoseltamab 用于治疗复发/难治性多发性骨髓瘤

Bumma, Naresh; Richter, Joshua; Jagannath, Sundar; Lee, Hans C; Hoffman, James E; Suvannasankha, Attaya; Zonder, Jeffrey A; Shah, Mansi R; Lentzsch, Suzanne; Baz, Rachid; Maly, Joseph J; Namburi, Swathi; Pianko, Matthew J; Ye, Jing Christine; Wu, Ka Lung; Silbermann, Rebecca; Min, Chang-Ki; Vekemans, Marie-Christiane; Munder, Markus; Byun, Ja Min; Martínez-Lopez, Joaquín; Cassady, Kaniel; DeVeaux, Michelle; Chokshi, Dhruti; Boyapati, Anita; Hazra, Anasuya; Yancopoulos, George D; Sirulnik, L Andres; Rodriguez Lorenc, Karen; Kroog, Glenn S; Houvras, Yariv; Dhodapkar, Madhav V

Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials

Dupilumab治疗结节性痒疹患者:两项随机、双盲、安慰剂对照的3期试验

Yosipovitch, Gil; Mollanazar, Nicholas; Ständer, Sonja; Kwatra, Shawn G; Kim, Brian S; Laws, Elizabeth; Mannent, Leda P; Amin, Nikhil; Akinlade, Bolanle; Staudinger, Heribert W; Patel, Naimish; Yancopoulos, George D; Weinreich, David M; Wang, Sheldon; Shi, Genming; Bansal, Ashish; O'Malley, John T

Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial

Garetosmab治疗进行性骨化性纤维发育不良:一项随机、双盲、安慰剂对照的II期试验

Di Rocco, Maja; Forleo-Neto, Eduardo; Pignolo, Robert J; Keen, Richard; Orcel, Philippe; Funck-Brentano, Thomas; Roux, Christian; Kolta, Sami; Madeo, Annalisa; Bubbear, Judith S; Tabarkiewicz, Jacek; Szczepanek, Małgorzata; Bachiller-Corral, Javier; Cheung, Angela M; Dahir, Kathryn M; Botman, Esmée; Raijmakers, Pieter G; Al Mukaddam, Mona; Tile, Lianne; Portal-Celhay, Cynthia; Sarkar, Neena; Hou, Peijie; Musser, Bret J; Boyapati, Anita; Mohammadi, Kusha; Mellis, Scott J; Rankin, Andrew J; Economides, Aris N; Trotter, Dinko Gonzalez; Herman, Gary A; O'Meara, Sarah J; DelGizzi, Richard; Weinreich, David M; Yancopoulos, George D; Eekhoff, E Marelise W; Kaplan, Frederick S

Effect of High-Dose Intravitreal Aflibercept, 8 mg, in Patients With Neovascular Age-Related Macular Degeneration: The Phase 2 CANDELA Randomized Clinical Trial

高剂量玻璃体内注射阿柏西普(8毫克)治疗新生血管性年龄相关性黄斑变性患者的疗效:CANDELA II期随机临床试验

Wykoff, Charles C; Brown, David M; Reed, Kimberly; Berliner, Alyson J; Gerstenblith, Adam T; Breazna, Aurora; Abraham, Prema; Fein, Jordana G; Chu, Karen W; Clark, W Lloyd; Leal, Sergio; Schmelter, Thomas; Hirshberg, Boaz; Yancopoulos, George D; Vitti, Robert

Association of complement pathways with COVID-19 severity and outcomes

补体通路与 COVID-19 严重程度和预后的关联

Devalaraja-Narashimha, Kishor; Ehmann, Peter J; Huang, Cong; Ruan, Qin; Wipperman, Matthew F; Kaplan, Theodore; Liu, Chien; Afolayan, Simisola; Glass, David J; Mellis, Scott; Yancopoulos, George D; Hamilton, Jennifer D; MacDonnell, Scott; Hamon, Sara C; Boyapati, Anita; Morton, Lori

Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection: A Randomized Clinical Trial

皮下注射卡西利维单抗和伊姆维维单抗抗体组合与安慰剂对早期无症状SARS-CoV-2感染者发展为有症状COVID-19的影响:一项随机临床试验

O'Brien, Meagan P; Forleo-Neto, Eduardo; Sarkar, Neena; Isa, Flonza; Hou, Peijie; Chan, Kuo-Chen; Musser, Bret J; Bar, Katharine J; Barnabas, Ruanne V; Barouch, Dan H; Cohen, Myron S; Hurt, Christopher B; Burwen, Dale R; Marovich, Mary A; Brown, Elizabeth R; Heirman, Ingeborg; Davis, John D; Turner, Kenneth C; Ramesh, Divya; Mahmood, Adnan; Hooper, Andrea T; Hamilton, Jennifer D; Kim, Yunji; Purcell, Lisa A; Baum, Alina; Kyratsous, Christos A; Krainson, James; Perez-Perez, Richard; Mohseni, Rizwana; Kowal, Bari; DiCioccio, A Thomas; Geba, Gregory P; Stahl, Neil; Lipsich, Leah; Braunstein, Ned; Herman, Gary; Yancopoulos, George D; Weinreich, David M