Proteotoxic stress triggers TFEB- and TFE3-mediated autophagy and lysosomal biogenesis via non-canonical MTORC1 inactivation.
蛋白毒性应激通过非经典的 MTORC1 失活触发 TFEB 和 TFE3 介导的自噬和溶酶体生物合成。
期刊:Autophagy
影响因子:14.3
doi:10.1080/15548627.2025.2608973
Zhu Zhou, Yang Jing, Montefusco Sandro, Xia Siyu, Ou Jinhuan, Tong Haibo, Zeng Qingzhong, Xu Fengmei, Dai Lingyun, Sun Jichao, Xu Chengchao, Medina Diego Luis, Wang Jigang, Zhang Wei, Yang Chuanbin
表观遗传
MTOR
ORC1
TFE3
TFEB
Autophagy
mTOR
自噬