ManNAc attenuates Man5 glycoform abundance through GNE-mediated metabolic channeling of UDP-GlcNAc to N-glycosylation modifications via CMP-Neu5Ac biosynthesis
ManNAc 通过 GNE 介导的代谢途径,将 UDP-GlcNAc 转化为 N-糖基化修饰,进而通过 CMP-Neu5Ac 生物合成途径降低 Man5 糖型的丰度。
期刊:MAbs
影响因子:7.3
doi:10.1080/19420862.2025.2561823
Sun, Ruiqiang; Chai, Miaomiao; Man, Jiahao; Yang, Guiju; Shu, Hai; Wang, Qiancheng; Tian, Cong; Wang, Linlin; Liao, Shanhui; Zhang, Yifeng; Cao, Yanyan; Xia, Lisha; Yang, Haili; Zhang, Ting; Ma, Luoyan; Cao, Shenwang; Gao, Qiao; Le, Yichen; Shi, Mingli; Li, Quanxue; Fan, Yinmao; Zhou, Hang