日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PEAKS activation by PROTAC EPIC-0726 potentiates temozolomide in glioblastoma via K63/K48 ubiquitination-dependent ERK/AKT suppression and p21 stabilization

PROTAC EPIC-0726 通过 K63/K48 泛素化依赖的 ERK/AKT 抑制和 p21 稳定增强 PEAKS 激活,从而增强替莫唑胺在胶质母细胞瘤中的疗效。

Hong, Biao; Su, Dongyuan; Cui, Xiaoteng; Zhao, Jixing; Wang, Qixue; Zhan, Qi; Yang, Eryan; Yang, Shixue; Ju, Jiasheng; Huang, Yanping; Cheng, Chunchao; Ding, Yaqing; Xu, Hanyi; Cui, Longtao; Zhao, Yilin; Zhao, Xun; Liang, Siwen; Liu, Yuhao; Kang, Chunsheng

LPC-engineered liposomes activate transcytosis for paclitaxel brain delivery and potentiation of TTFields/TMZ via TALECT regimen in glioblastoma

LPC工程化脂质体通过TALECT方案激活胞吞作用,将紫杉醇递送至脑部,并增强TTFields/TMZ在胶质母细胞瘤中的疗效。

Zhan, Qi; Yi, Kaikai; Yang, Shixue; Hong, Biao; Su, Dongyuan; Zhao, Jixing; Wang, Qixue; Cui, Xiaoteng; Huang, Yanping; Ding, Yaqing; Cheng, Chunchao; Ju, Jiasheng; Kang, Chunsheng

Linagliptin synergizes with cPLA2 inhibition to enhance temozolomide efficacy by interrupting DPP4-mediated EGFR stabilization in glioma.

利格列汀与 cPLA2 抑制剂协同作用,通过干扰 DPP4 介导的 EGFR 在胶质瘤中的稳定作用来增强替莫唑胺的疗效

Su Dongyuan, Hong Biao, Yang Shixue, Zhao Jixing, Cui Xiaoteng, Zhan Qi, Yi Kaikai, Huang Yanping, Ju Jiasheng, Yang Eryan, Wang Qixue, Zhou Junhu, Wang Yunfei, Liu Xing, Kang Chunsheng

Endothelial cell-derived SDF-1α elicits stemness traits of glioblastoma via dual-regulation of GLI1.

内皮细胞衍生的 SDF-1α 通过对 GLI1 的双重调控引发胶质母细胞瘤的干性特征

Yuan Ye, Liu Xudong, Kuang Liwen, Yang Shixue, Wang Lihong, Wang Jiao, Wei Sen, Yan Zexuan, Ma Qinghua, Lei Juan, Zhou Yu, Chen Yu, Chen Jiongming, Luo Tao, Yang Kaidi, Zhang Mengsi, Li Yongsheng

HIF1α/ATF3 partake in PGK1 K191/K192 succinylation by modulating P4HA1/succinate signaling in glioblastoma

HIF1α/ATF3通过调节胶质母细胞瘤中的P4HA1/琥珀酸信号通路参与PGK1 K191/K192的琥珀酰化。

Yang, Shixue; Zhan, Qi; Su, Dongyuan; Cui, Xiaoteng; Zhao, Jixing; Wang, Qixue; Hong, Biao; Ju, Jiasheng; Cheng, Chunchao; Yang, Eryan; Kang, Chunsheng

EPIC-1042 as a potent PTRF/Cavin1-caveolin-1 interaction inhibitor to induce PARP1 autophagic degradation and suppress temozolomide efflux for glioblastoma

EPIC-1042 是一种强效的 PTRF/Cavin1-caveolin-1 相互作用抑制剂,可诱导 PARP1 自噬降解并抑制替莫唑胺外排,用于治疗胶质母细胞瘤。

Hong, Biao; Yang, Eryan; Su, Dongyuan; Ju, Jiasheng; Cui, Xiaoteng; Wang, Qixue; Tong, Fei; Zhao, Jixing; Yang, Shixue; Cheng, Chunchao; Xin, Lei; Xiao, Menglin; Yi, Kaikai; Zhan, Qi; Ding, Yaqing; Xu, Hanyi; Cui, Longtao; Kang, Chunsheng

Modulation of gut microbiota in targeted cancer therapy: insights on the EGFR/VEGF/KRAS pathways

靶向癌症治疗中肠道菌群的调控:EGFR/VEGF/KRAS通路的研究进展

Gong, Li; Yang, Shixue; Huang, Junli; Li, Yongsheng

A novel compound EPIC-0412 reverses temozolomide resistance via inhibiting DNA repair/MGMT in glioblastoma

一种新型化合物 EPIC-0412 通过抑制胶质母细胞瘤中的 DNA 修复/MGMT 来逆转替莫唑胺耐药性

Zhao, Jixing; Yang, Shixue; Cui, Xiaoteng; Wang, Qixue; Yang, Eryan; Tong, Fei; Hong, Biao; Xiao, Menglin; Xin, Lei; Xu, Can; Tan, Yanli; Kang, Chunsheng

Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma

EGFR/AKT 和甲羟戊酸通路阻断可通过重编程胶质母细胞瘤中的能量代谢来协同替莫唑胺的抗肿瘤作用

Xiaoteng Cui, Jixing Zhao, Guanzhang Li, Chao Yang, Shixue Yang, Qi Zhan, Junhu Zhou, Yunfei Wang, Menglin Xiao, Biao Hong, Kaikai Yi, Fei Tong, Yanli Tan, Hu Wang, Qixue Wang, Tao Jiang, Chuan Fang, Chunsheng Kang

Endarterectomy versus stenting for the prevention of periprocedural stroke or death in patients with symptomatic or asymptomatic carotid stenosis: a meta-analysis of 10 randomized trials

颈动脉内膜剥脱术与支架置入术预防有症状或无症状颈动脉狭窄患者围手术期卒中或死亡的疗效比较:一项包含10项随机试验的荟萃分析

Xin, Wenqiang; Yang, Shixue; Li, Qifeng; Yang, Xinyu