日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Real-time imaging of protein microenvironment changes in cells with rotor-based fluorescent amino acids

利用基于转子的荧光氨基酸对细胞内蛋白质微环境变化进行实时成像

期刊:Nature Chemical Biology
影响因子:13.7
doi:10.1038/s41589-025-02003-1
Yang, Shudan; Jin, Shikai; Zhang, Mengxi; Chen, Yuda; Guo, Yiming; Hu, Yu; Wolynes, Peter G; Xiao, Han
细胞生物学
IF
发表日期：2026
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Identification of novel HIF2α inhibitors: a structure-based virtual screening approach

新型HIF2α抑制剂的鉴定：基于结构的虚拟筛选方法

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2025.2606435
Zhou, Shasha; Yin, Shengnan; Yang, Shudan; Wang, Yuting; Feng, Panfeng
发表日期：2026
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Identification of a peptide inhibitor disrupting the PCSK9-LDLR interaction via pharmacophore-based virtual screening, molecular dynamics simulations and in vitro/vivo evaluation.

通过基于药效团的虚拟筛选、分子动力学模拟和体外/体内评价，鉴定出一种能够破坏 PCSK9-LDLR 相互作用的肽抑制剂。

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2025.2610849
Wu Wanling, Yang Shudan, Liu Jie, Wang Yuting, Pan Defeng, Zhou Yafeng
CSK
LDLR
PCSK9
发表日期：2026
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Engineering unnatural cells with a 21st amino acid as a living epigenetic sensor.

利用第 21 个氨基酸作为活体表观遗传传感器改造非天然细胞。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-64448-1
Hu Yu, Wang Yixian, Cheng Linqi, Wang Chenhang, Liu Yijie, Wang Yufei, Chen Yuda, Yang Shudan, Guo Yiming, Jiang Shiyu, Yang Kaiqiang, Xiao Han
细胞生物学
发表日期：2025
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Structure-based design of new potent and highly selective PARP-1 inhibitor for treating colorectal cancer

基于结构的新型高效高选择性PARP-1抑制剂设计用于治疗结直肠癌

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2025.2542358
Jiang, Chunying; Yang, Shudan; Wang, Yuting; Du, Liyuan; Niu, Miao-Miao; Zhang, Dongli
肿瘤
肠癌
肿瘤免疫
PARP
发表日期：2025
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Discovery and biological evaluation of a novel and highly potent JAK2 inhibitor for the treatment of triple negative breast cancer

发现并生物学评价一种新型高效JAK2抑制剂在治疗三阴性乳腺癌中的应用

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2025.2488127
Miao, Yingxiang; Yang, Shudan; Zhang, Fang; Li, Jindong; Zhang, Yan
肿瘤
肿瘤免疫
JAK/STAT
乳腺癌
JAK2
发表日期：2025
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Identification of a novel and high-affinity cyclic peptide targeting Keap1 for inflammation treatment by a combined virtual screening strategy.

通过结合虚拟筛选策略，鉴定出一种靶向 Keap1 的新型高亲和力环状肽，用于炎症治疗。

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2025.2574023
Gao Shenglin, Shi Xiaokai, Yang Shudan, Wang Yuting, Wang Qian, Yang Minyan
炎症/感染
KEAP1
Immunology/Inflammation
炎症
发表日期：2025
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Identification of a novel and high affinity MIF inhibitor via structure-based pharmacophore modelling, molecular docking, molecular dynamics simulations, and biological evaluation.

通过基于结构的药效团建模、分子对接、分子动力学模拟和生物学评价，鉴定出一种新型高亲和力的MIF抑制剂

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2025.2501378
Zhu Shang, Yang Shudan, Chen Yao, Niu Miao-Miao, Wang Jun, Li Jindong, Pu Xuehua
信号转导
发表日期：2025
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Harnessing Nature-Inspired Catechol Amino Acid to Engineer Sticky Proteins and Bacteria

利用仿生儿茶酚氨基酸改造粘性蛋白和细菌

期刊:Small Methods
影响因子:9.1
doi:10.1002/smtd.202400230
Zhang, Mengxi; Chen, Yuda; Chung, Anna; Yang, Shudan; Choi, Chi Hun; Zhang, Sophie; Han, Yimo; Xiao, Han
微生物学
发表日期：2024
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Advancements in boron difluoride formazanate dyes for biological imaging

二氟化硼甲脒酸盐染料在生物成像领域的进展

期刊:Current Opinion in Chemical Biology
影响因子:6.1
doi:10.1016/j.cbpa.2024.102473
Yang, Shudan; Lu, Kang; Xiao, Han
发表日期：2024
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