日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural and biochemical basis of ROC-dependent activation of LRRK2

ROC依赖性LRRK2激活的结构和生化基础

Park, Yangshin; Wu, Chunxiang; Tennessen, Kayla; Wan, Li; Hoang, Neo C; Hoang, Cardea W; Liao, Jingling; Hoang, Quyen Q

Potency of human hematopoietic cells from a novel CD34+ isolation technique

一种新型CD34+分离技术获得的造血细胞的效力

Ropa, James; Park, Jimin; Newton, Jessica; Kim, So Jeong; Park, Yangshin; Messer, Jonathan; Blacher, Justin; Namin, Shabnam

Allosteric differences dictate GroEL complementation of E. coli

变构差异决定了 GroEL 对大肠杆菌的互补作用

Sivinski, Jared; Ngo, Duc; Zerio, Christopher J; Ambrose, Andrew J; Watson, Edmond R; Kaneko, Lynn K; Kostelic, Marius M; Stevens, Mckayla; Ray, Anne-Marie; Park, Yangshin; Wu, Chunxiang; Marty, Michael T; Hoang, Quyen Q; Zhang, Donna D; Lander, Gabriel C; Johnson, Steven M; Chapman, Eli

A new alpha-synuclein missense variant (Thr72Met) in two Turkish families with Parkinson's disease

土耳其两个帕金森病家族中发现新的 α-突触核蛋白错义变体 (Thr72Met)

Christina Fevga, Yangshin Park, Ebba Lohmann, Anneke J Kievit, Guido J Breedveld, Federico Ferraro, Leon de Boer, Rick van Minkelen, Hasmet Hanagasi, Agnita Boon, Wei Wang, Gregory A Petsko, Quyen Q Hoang, Murat Emre, Vincenzo Bonifati

Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs.

硝基呋喃类抗生素的类似物是强效的 GroEL/ES 抑制剂前药

Stevens Mckayla, Howe Chris, Ray Anne-Marie, Washburn Alex, Chitre Siddhi, Sivinski Jared, Park Yangshin, Hoang Quyen Q, Chapman Eli, Johnson Steven M

The Parkinson's disease-associated mutation N1437H impairs conformational dynamics in the G domain of LRRK2

帕金森病相关突变 N1437H 会损害 LRRK2 的 G 结构域的构象动力学

Xiaorong Huang, Chunxiang Wu, Yangshin Park, Xuwei Long, Quyen Q Hoang, Jingling Liao

Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics.

LRRK2 GTPase 结构域中与帕金森病相关的突变会损害其核苷酸依赖性构象动力学

Wu Chun-Xiang, Liao Jingling, Park Yangshin, Reed Xylena, Engel Victoria A, Hoang Neo C, Takagi Yuichiro, Johnson Steven M, Wang Mu, Federici Mark, Nichols R Jeremy, Sanishvili Ruslan, Cookson Mark R, Hoang Quyen Q

HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules

多种已批准的药物、天然产物和已知的生物活性分子均可抑制HSP60/10分子伴侣系统。

Stevens, Mckayla; Abdeen, Sanofar; Salim, Nilshad; Ray, Anne-Marie; Washburn, Alex; Chitre, Siddhi; Sivinski, Jared; Park, Yangshin; Hoang, Quyen Q; Chapman, Eli; Johnson, Steven M

Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections

双靶向GroEL/ES分子伴侣和蛋白酪氨酸磷酸酶B (PtpB) 抑制剂:治疗结核分枝杆菌感染的多药理学策略

Washburn, Alex; Abdeen, Sanofar; Ovechkina, Yulia; Ray, Anne-Marie; Stevens, Mckayla; Chitre, Siddhi; Sivinski, Jared; Park, Yangshin; Johnson, James; Hoang, Quyen Q; Chapman, Eli; Parish, Tanya; Johnson, Steven M

Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA)

磺酰胺-2-芳基苯并恶唑 GroEL/ES 抑制剂可作为抗耐甲氧西林金黄色葡萄球菌 (MRSA) 的强效抗菌剂

Sanofar Abdeen, Trent Kunkle, Nilshad Salim, Anne-Marie Ray, Najiba Mammadova, Corey Summers, Mckayla Stevens, Andrew J Ambrose, Yangshin Park, Peter G Schultz, Arthur L Horwich, Quyen Q Hoang, Eli Chapman, Steven M Johnson