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日期影响因子

HDAC6 Inhibition Reduces Seeded Tau and α-Synuclein Pathologies in Primary Neuron Cultures and Wild-Type Mice

HDAC6抑制剂可减少原代神经元培养物和野生型小鼠中播散的tau蛋白和α-突触核蛋白病理

期刊:Journal of Neuroscience

doi:10.1523/JNEUROSCI.1092-25.2025

Crowe, Alex; Yao, Yuemang; Newman, Mira; Hoxha, Kevt'her; Baffic, Thallyah; Brunden, Kurt R

发表日期：2026

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Photoaffinity labeling of protein targets in a complex metazoan: proof-of-concept using a probe for Schistosoma mansoni tubulin

利用光亲和标记技术对复杂后生动物中的蛋白质靶标进行标记：以曼氏血吸虫微管蛋白探针为例的概念验证

doi:10.1101/2025.10.04.680471

Lucero, Bobby; Alle, Thibault; Bufano, Marianna; Yao, Yuemang; Brunden, Kurt R; Brancale, Andrea; Ballatore, Carlo; Francisco, Karol R; Caffrey, Conor R

发表日期：2025

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Design, Synthesis, and Evaluation of An Anti-trypanosomal [1,2,4]Triazolo[1,5-a]pyrimidine Probe for Photoaffinity Labeling Studies.

设计、合成和评价抗锥虫[1,2,4]三唑并[1,5-a]嘧啶探针用于光亲和标记研究

期刊:ChemMedChem

影响因子:3.4

doi:10.1002/cmdc.202300656

Lucero Bobby, Francisco Karol R, Varricchio Carmine, Liu Lawrence J, Yao Yuemang, Brancale Andrea, Brunden Kurt R, Caffrey Conor R, Ballatore Carlo

发表日期：2024

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Correction of microtubule defects within Aβ plaque-associated dystrophic axons results in lowered Aβ release and plaque deposition

纠正Aβ斑块相关营养不良轴突内的微管缺陷可降低Aβ释放和斑块沉积。

期刊:Alzheimers & Dementia

影响因子:11.1

doi:10.1002/alz.12144

Yao, Yuemang; Nzou, Goodwell; Alle, Thibault; Tsering, Wangchen; Maimaiti, Shaniya; Trojanowski, John Q; Lee, Virginia M-Y; Ballatore, Carlo; Brunden, Kurt R

发表日期：2020

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Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines

微管（MT）活性[1,2,4]三唑并[1,5-a]嘧啶的光活化衍生物的设计、合成和评价

期刊:Bioorganic & Medicinal Chemistry Letters

影响因子:2.2

doi:10.1016/j.bmcl.2018.05.010

Oukoloff, Killian; Kovalevich, Jane; Cornec, Anne-Sophie; Yao, Yuemang; Owyang, Zachary A; James, Michael; Trojanowski, John Q; Lee, Virginia M-Y; Smith, Amos B 3rd; Brunden, Kurt R; Ballatore, Carlo

发表日期：2018

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Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group

对氧杂环丁烷-3-醇、噻丁烷-3-醇及其衍生物作为羧酸官能团生物等排体的评价

期刊:ACS Medicinal Chemistry Letters

doi:10.1021/acsmedchemlett.7b00212

Lassalas, Pierrik; Oukoloff, Killian; Makani, Vishruti; James, Michael; Tran, Van; Yao, Yuemang; Huang, Longchuan; Vijayendran, Krishna; Monti, Ludovica; Trojanowski, John Q; Lee, Virginia M-Y; Kozlowski, Marisa C; Smith, Amos B 3rd; Brunden, Kurt R; Ballatore, Carlo

发表日期：2017

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Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy

在PS19 tau转基因小鼠tau蛋白病模型中评估脑穿透性微管稳定剂dictyostatin的作用

期刊:Acta Neuropathologica Communications

影响因子:5.7

doi:10.1186/s40478-016-0378-4

Makani, Vishruti; Zhang, Bin; Han, Heeoon; Yao, Yuemang; Lassalas, Pierrik; Lou, Kevin; Paterson, Ian; Lee, Virginia M Y; Trojanowski, John Q; Ballatore, Carlo; Smith, Amos B 3rd; Brunden, Kurt R

发表日期：2016

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MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications

MT稳定剂Dictyostatin表现出持久的脑内滞留和活性：潜在的治疗意义

期刊:ACS Medicinal Chemistry Letters

doi:10.1021/ml400233e

Brunden, Kurt R; Gardner, Nicola M; James, Michael J; Yao, Yuemang; Trojanowski, John Q; Lee, Virginia M-Y; Paterson, Ian; Ballatore, Carlo; Smith, Amos B 3rd

发表日期：2013

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Aminothienopyridazine inhibitors of tau aggregation: evaluation of structure-activity relationship leads to selection of candidates with desirable in vivo properties

氨基噻吩并哒嗪类tau蛋白聚集抑制剂：构效关系评估筛选出具有理想体内特性的候选药物

期刊:Bioorganic & Medicinal Chemistry

doi:10.1016/j.bmc.2012.05.027

Ballatore, Carlo; Crowe, Alex; Piscitelli, Francesco; James, Michael; Lou, Kevin; Rossidivito, Gabrielle; Yao, Yuemang; Trojanowski, John Q; Lee, Virginia M-Y; Brunden, Kurt R; Smith, Amos B 3rd

发表日期：2012

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