日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A CD8αβ co-receptor modified to contain an intracellular CD28 signaling tail enhances TCR-engineered T cell function independent of solid-tumor-associated co-stimulatory ligands

经过修饰,含有胞内 CD28 信号尾的 CD8αβ 共受体可增强 TCR 工程化 T 细胞的功能,且该功能不依赖于实体瘤相关的共刺激配体。

Shihong Zhang #,Tzu-Hao Tang #,Sinéad Kinsella #,Francesco Mazziotta,Michael T Schweizer,Megan S McAfee,Ariunaa Munkhbat,Yapeng Su,Valentin Voillet,Lauren E Martin,Colton W Smith,Yuta Asano,Menna Hailemariam,Jakob Bakhtiari,Bo Lee,Cecilia Yeung,Hung Chen,Alessandro M Rizzi,Daniel G Chen,Kelsey Furiya,Nick Horst,Tianzi Zhang,Phung Le,Kelly McKenna,Shannon K Oda,Anthony Rongvaux,Phillip D Greenberg,Thomas M Schmitt,Aude G Chapuis

Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity

甘露糖代谢重塑T细胞分化,从而增强抗肿瘤免疫力

Yajing Qiu,Yapeng Su,Ermei Xie,Hongcheng Cheng,Jing Du,Yue Xu,Xiaoli Pan,Zhe Wang,Daniel G Chen,Hong Zhu,Philip D Greenberg,Guideng Li

APMAT analysis reveals the association between CD8 T cell receptors, cognate antigen, and T cell phenotype and persistence

APMAT 分析揭示了 CD8 T 细胞受体、同源抗原、T 细胞表型和持久性之间的关联

Jingyi Xie ,Daniel G Chen ,William Chour ,Rachel H Ng ,Rongyu Zhang ,Dan Yuan ,Jongchan Choi ,Michaela McKasson ,Pamela Troisch ,Brett Smith ,Lesley Jones ,Andrew Webster ,Yusuf Rasheed ,Sarah Li ,Rick Edmark ,Sunga Hong ,Kim M Murray ,Jennifer K Logue ,Nicholas M Franko ,Christopher G Lausted ,Brian Piening ,Heather Algren ,Julie Wallick ,Andrew T Magis ,Kino Watanabe ,Phil Mease ,Philip D Greenberg ,Helen Chu ,Jason D Goldman ,Yapeng Su ,James R Heath

Integrative systems biology reveals NKG2A-biased immune responses correlate with protection in infectious disease, autoimmune disease, and cancer

整合系统生物学揭示,NKG2A偏向性免疫反应与传染病、自身免疫性疾病和癌症的保护作用相关。

Daniel G Chen ,Jingyi Xie ,Jongchan Choi ,Rachel H Ng ,Rongyu Zhang ,Sarah Li ,Rick Edmark ,Hong Zheng ,Ben Solomon ,Katie M Campbell ,Egmidio Medina ,Antoni Ribas ,Purvesh Khatri ,Lewis L Lanier ,Philip J Mease ,Jason D Goldman ,Yapeng Su ,James R Heath

Entropic analysis of antigen-specific CDR3 domains identifies essential binding motifs shared by CDR3s with different antigen specificities

抗原特异性 CDR3 结构域的熵分析可识别具有不同抗原特异性的 CDR3 所共有的基本结合基序

Alexander M Xu, William Chour, Diana C DeLucia, Yapeng Su, Ana Jimena Pavlovitch-Bedzyk, Rachel Ng, Yusuf Rasheed, Mark M Davis, John K Lee, James R Heath

Stereochemical engineering yields a multifunctional peptide macrocycle inhibitor of Akt2 by fine-tuning macrocycle-cell membrane interactions

立体化学工程通过微调大环-细胞膜相互作用产生 Akt2 的多功能肽大环抑制剂

Arundhati Nag, Amirhossein Mafi, Samir Das, Mary Beth Yu, Belen Alvarez-Villalonga, Soo-Kyung Kim, Yapeng Su, William A Goddard 3rd, James R Heath

Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis

大型单链三聚体肽-MHC 库可实现抗原特异性 CD8+ T 细胞的发现和分析

William Chour #, Jongchan Choi #, Jingyi Xie, Mary E Chaffee, Thomas M Schmitt, Kathryn Finton, Diana C DeLucia, Alexander M Xu, Yapeng Su, Daniel G Chen, Rongyu Zhang, Dan Yuan, Sunga Hong, Alphonsus H C Ng, Jonah Z Butler, Rick A Edmark, Lesley C Jones, Kim M Murray, Songming Peng, Guideng Li, Rol

An NKG2A biased immune response confers protection for infection, autoimmune disease, and cancer

NKG2A 偏向的免疫反应可预防感染、自身免疫性疾病和癌症

James Heath, Daniel Chen, Jingyi Xie, Jongchan Choi, Rachel Ng, Rongyu Zhang, Sarah Li, Rick Edmark, Hong Zheng, Benjamin Solomon, Katie Campbell, Egmidio Medina, Antoni Ribas, Purvesh Khatri, Lewis Lanier, Philip Mease, Jason Goldman, Yapeng Su

Multiple early factors anticipate post-acute COVID-19 sequelae

多种早期因素预示着新冠肺炎急性期后遗症的发生

Yapeng Su ,Dan Yuan ,Daniel G Chen ,Rachel H Ng ,Kai Wang ,Jongchan Choi ,Sarah Li ,Sunga Hong ,Rongyu Zhang ,Jingyi Xie ,Sergey A Kornilov ,Kelsey Scherler ,Ana Jimena Pavlovitch-Bedzyk ,Shen Dong ,Christopher Lausted ,Inyoul Lee ,Shannon Fallen ,Chengzhen L Dai ,Priyanka Baloni ,Brett Smith ,Venkata R Duvvuri ,Kristin G Anderson ,Jing Li ,Fan Yang ,Caroline J Duncombe ,Denise J McCulloch ,Clifford Rostomily ,Pamela Troisch ,Jing Zhou ,Sean Mackay ,Quinn DeGottardi ,Damon H May ,Ruth Taniguchi ,Rachel M Gittelman ,Mark Klinger ,Thomas M Snyder ,Ryan Roper ,Gladys Wojciechowska ,Kim Murray ,Rick Edmark ,Simon Evans ,Lesley Jones ,Yong Zhou ,Lee Rowen ,Rachel Liu ,William Chour ,Heather A Algren ,William R Berrington ,Julie A Wallick ,Rebecca A Cochran ,Mary E Micikas ,Christos J Petropoulos ,Hunter R Cole ,Trevan D Fischer ,Wei Wei ,Dave S B Hoon ,Nathan D Price ,Naeha Subramanian ,Joshua A Hill ,Jennifer Hadlock ,Andrew T Magis ,Antoni Ribas ,Lewis L Lanier ,Scott D Boyd ,Jeffrey A Bluestone ,Helen Chu ,Leroy Hood ,Raphael Gottardo ,Philip D Greenberg ,Mark M Davis ,Jason D Goldman ,James R Heath

KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19

KIR+CD8+ T细胞抑制致病性T细胞,并在自身免疫性疾病和COVID-19中发挥作用。

Jing Li ,Maxim Zaslavsky ,Yapeng Su ,Jing Guo ,Michael J Sikora ,Vincent van Unen ,Asbjørn Christophersen ,Shin-Heng Chiou ,Liang Chen ,Jiefu Li ,Xuhuai Ji ,Julie Wilhelmy ,Alana M McSween ,Brad A Palanski ,Venkata Vamsee Aditya Mallajosyula ,Nathan A Bracey ,Gopal Krishna R Dhondalay ,Kartik Bhamidipati ,Joy Pai ,Lucas B Kipp ,Jeffrey E Dunn ,Stephen L Hauser ,Jorge R Oksenberg ,Ansuman T Satpathy ,William H Robinson ,Cornelia L Dekker ,Lars M Steinmetz ,Chaitan Khosla ,Paul J Utz ,Ludvig M Sollid ,Yueh-Hsiu Chien ,James R Heath ,Nielsen Q Fernandez-Becker ,Kari C Nadeau ,Naresha Saligrama ,Mark M Davis