日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The glymphatic system clears amyloid beta and tau from brain to plasma in humans

在人类体内,淋巴系统负责将β-淀粉样蛋白和tau蛋白从大脑清除到血浆中。

Dagum, Paul; Elbert, Donald L; Giovangrandi, Laurent; Singh, Tarandeep; Venkatesh, Venky V; Corbellini, Alejandro; Kaplan, Robert M; Levendovszky, Swati Rane; Ludington, Elizabeth; Yarasheski, Kevin; Lowenkron, Jeffrey; VandeWeerd, Carla; Lim, Miranda M; Iliff, Jeffrey J

Accuracy of plasma biomarkers to detect Alzheimer's disease proteinopathy prior to dementia

血浆生物标志物在痴呆症发生前检测阿尔茨海默病蛋白病变的准确性

Cody, Karly A; Du, Lianlian; Studer, Rachel L; Jonaitis, Erin M; Asthana, Sanjay; Christian, Bradley T; Chin, Nathaniel A; Kirmess, Kris M; Meyer, Matthew R; Yarasheski, Kevin E; West, Tim; Verghese, Philip B; Braunstein, Joel B; Betthauser, Tobey J; Langhough, Rebecca E; Johnson, Sterling C

Independent validation of the PrecivityAD2(™) blood test to identify presence or absence of brain amyloid pathology in individuals with cognitive impairment

独立验证 PrecivityAD2™ 血液检测在识别认知障碍患者脑内淀粉样蛋白病理存在与否方面的有效性

Coppinger, Justine; West, Tim; Kirmess, Kris M; Fogelman, Ilana; Ray, Sutapa; Aurora, Sheena; Verghese, Philip B; Braunstein, Joel B; Yarasheski, Kevin E

Independent validation of the PrecivityAD2™ blood test to identify presence or absence of brain amyloid pathology in individuals with cognitive impairment

独立验证PrecivityAD2™血液检测在识别认知障碍患者脑内淀粉样蛋白病理存在与否方面的有效性

Coppinger, Justine; West, Tim; Kirmess, Kris M; Fogelman, Ilana; Ray, Sutapa; Verghese, Philip B; Braunstein, Joel B; Yarasheski, Kevin E

Plasma Aβ42/Aβ40 and phospho-tau217 concentration ratios increase the accuracy of amyloid PET classification in preclinical Alzheimer's disease

血浆Aβ42/Aβ40和磷酸化tau217浓度比值可提高临床前阿尔茨海默病中淀粉样蛋白PET分类的准确性

Rissman, Robert A; Langford, Oliver; Raman, Rema; Donohue, Michael C; Abdel-Latif, Sara; Meyer, Matthew R; Wente-Roth, Traci; Kirmess, Kristopher M; Ngolab, Jennifer; Winston, Charisse N; Jimenez-Maggiora, Gustavo; Rafii, Michael S; Sachdev, Pallavi; West, Tim; Yarasheski, Kevin E; Braunstein, Joel B; Irizarry, Michael; Johnson, Keith A; Aisen, Paul S; Sperling, Reisa A

Racial and ethnic differences in plasma biomarker eligibility for a preclinical Alzheimer's disease trial

种族和民族差异导致血浆生物标志物在阿尔茨海默病临床前试验中的适用性受到影响

Molina-Henry, Doris Patricia; Raman, Rema; Liu, Andy; Langford, Oliver; Johnson, Keith; Shum, Leona K; Glover, Crystal M; Dhadda, Shobha; Irizarry, Michael; Jimenez-Maggiora, Gustavo; Braunstein, Joel B; Yarasheski, Kevin; Venkatesh, Venky; West, Tim; Verghese, Philip B; Rissman, Robert A; Aisen, Paul; Grill, Joshua D; Sperling, Reisa A

The AlzMatch Pilot Study - Feasibility of Remote Blood Collection of Plasma Biomarkers for Preclinical Alzheimer's Disease Trials

AlzMatch试点研究——远程采集血浆生物标志物用于阿尔茨海默病临床前试验的可行性

Walter, S; Langford, O; Jimenez-Maggiora, G A; Abdel-Latif, S; Rissman, R A; Grill, J D; Karlawish, J; Atri, A; Bruschi, S; Hussen, K; Donohue, M C; Marshall, G A; Jicha, G; Racke, M; Turner, R S; van Dyck, C H; Venkatesh, V; Yarasheski, K E; Sperling, R; Cummings, J; Aisen, P S; Raman, R

Associations of sleep duration and daytime sleepiness with plasma amyloid beta and cognitive performance in cognitively unimpaired, middle-aged and older African Americans

睡眠时长和日间嗜睡与血浆β-淀粉样蛋白和认知能力之间的关联,研究对象为认知功能正常的非裔美国人中年人和老年人

Cook, Jesse D; Malik, Ammara; Plante, David T; Norton, Derek; Langhough Koscik, Rebecca; Du, Lianlian; Bendlin, Barbara B; Kirmess, Kris M; Holubasch, Mary S; Meyer, Matthew R; Venkatesh, Venky; West, Tim; Verghese, Philip B; Yarasheski, Kevin E; Thomas, Kevin V; Carlsson, Cynthia M; Asthana, Sanjay; Johnson, Sterling C; Gleason, Carey E; Zuelsdorff, Megan

The Association of Alzheimer's Disease-Related Blood-Based Biomarkers with Cognitive Screening Test Performance in the Congolese Population in Kinshasa

阿尔茨海默病相关血液生物标志物与金沙萨刚果人群认知筛查测试表现的关联性研究

Schwinne, Megan; Alonso, Alvaro; Roberts, Blaine R; Hickle, Sabrina; Verberk, Inge M W; Epenge, Emmanuel; Gikelekele, Guy; Tsengele, Nathan; Kavugho, Immaculee; Mampunza, Samuel; Yarasheski, Kevin E; Teunissen, Charlotte E; Stringer, Anthony; Levey, Allan; Ikanga, Jean

Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimer's disease (BenfoTeam)

一项无缝衔接的 2A 期-2B 期随机双盲安慰剂对照试验方案,旨在评估苯磷硫胺在早期阿尔茨海默病患者中的安全性和有效性(BenfoTeam)

Feldman, Howard H; Luchsinger, José A; Léger, Gabriel C; Taylor, Curtis; Jacobs, Diane M; Salmon, David P; Edland, Steven D; Messer, Karen; Revta, Carolyn; Flowers, Sarah A; Jones, Kerry S; Koulman, Albert; Yarasheski, Kevin E; Verghese, Philip B; Venkatesh, Venky; Zetterberg, Henrik; Durant, January; Lupo, Jody-Lynn; Gibson, Gary E