Bacterial steroid-17,20-desmolase is a taxonomically rare enzymatic pathway that converts prednisone to 1,4-androstanediene-3,11,17-trione, a metabolite that causes proliferation of prostate cancer cells
细菌类固醇-17,20-去甲基酶是一种分类学上罕见的酶促途径,可将泼尼松转化为 1,4-雄烷二烯-3,11,17-三酮,后者是一种导致前列腺癌细胞增殖的代谢物
期刊:Journal of Steroid Biochemistry and Molecular Biology
影响因子:2.7
doi:10.1016/j.jsbmb.2019.105567
Lindsey K Ly, Joe L Rowles 3rd, Hans Müller Paul, João M P Alves, Camdon Yemm, Patricia M Wolf, Saravanan Devendran, Matthew E Hudson, David J Morris, John W Erdman Jr, Jason M Ridlon0