日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Identification and biological evaluation of benzimidazole-based compounds as novel TGFβR1 inhibitors

鉴定和生物学评价苯并咪唑类化合物作为新型TGFβR1抑制剂

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2025.2600746
Tseng, Hui-Ju; Wu, Yi-Wen; Chen, Yan-Ling; Lin, Tony Eight; Fang-Chin, Yu-Ting; Wu, Yueh-Lin; Sung, Tzu-Ying; Yen, Shih-Chung; Hsieh, Jui-Hua; Hsu, Kai-Cheng; Pan, Shiow-Lin
TGFβ
发表日期：2026
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Consensus Pharmacological Interactions for PLK2 Inhibitor Identification in Colorectal Cancer Treatment

结直肠癌治疗中PLK2抑制剂鉴定的共识药理学相互作用

期刊:Journal of Chemical Information and Modeling
影响因子:5.3
doi:10.1021/acs.jcim.5c02197
Wu, Yi-Wen; Yang, Chun-Lin; Lin, Tony Eight; Yeh, Yun-Hsuan; Fang-Chin, Yu-Ting; Sung, Tzu-Ying; Yen, Shih-Chung; Hsieh, Jui-Hua; Chung, Cheng-Chih; Pan, Shiow-Lin; Hsu, Kai-Cheng
肿瘤
肠癌
肿瘤免疫
发表日期：2026
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SARST2 high-throughput and resource-efficient protein structure alignment against massive databases

SARST2 高通量、资源高效的蛋白质结构比对，目标数据库规模庞大

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-63757-9
Lo, Wei-Cheng; Warshel, Arieh; Lo, Chia-Hua; Choke, Chia Yee; Li, Yan-Jie; Yen, Shih-Chung; Yang, Jyun-Yi; Weng, Shih-Wen
发表日期：2025
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Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure-Based Virtual Screening.

利用基于结构的虚拟筛选方法鉴定和生物学评价一种靶向胰腺癌中选择性剪接的新型 CLK4 抑制剂

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202416323
Yang Chun-Lin, Wu Yi-Wen, Tu Huang-Ju, Yeh Yun-Hsuan, Lin Tony Eight, Sung Tzu-Ying, Li Mu-Chun, Yen Shih-Chung, Hsieh Jui-Hua, Yu Ming-Chin, Hsieh Sen-Yung, Hsieh Hsing-Pang, Pan Shiow-Lin, Hsu Kai-Cheng
肿瘤
胰腺癌
发表日期：2025
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Exploring diarylheptanoid derivatives to target LIMK1 as potential agents against colorectal cancer

探索以LIMK1为靶点的二芳基庚烷衍生物作为潜在的结直肠癌治疗药物

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2025.2583826
Chen, Liang-Chieh; Chang, Tung-Cheng; Tseng, Hui-Ju; Chu, Jung-Chun; Huang, Yun-Yi; Peng, Hao-Yuan; Kuo, Yi-Chen; Wu, Yi-Wen; Lin, Tony Eight; Yen, Shih-Chung; Hsu, Kai-Cheng; Huang, Wei-Jan; Pan, Shiow-Lin
肿瘤
肠癌
肿瘤免疫
LIMK1
发表日期：2025
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Identification of a Potent CDK8 Inhibitor Using Structure-Based Virtual Screening

利用基于结构的虚拟筛选鉴定高效 CDK8 抑制剂

期刊:Journal of Chemical Information and Modeling
影响因子:5.3
doi:10.1021/acs.jcim.4c02011
Lin, Tony Eight; Chou, Ching-Hsuan; Wu, Yi-Wen; Sung, Tzu-Ying; Hsu, Jui-Yi; Yen, Shih-Chung; Hsieh, Jui-Hua; Chang, Yu-Wei; Pan, Shiow-Lin; Huang, Wei-Jan; Hsu, Kai-Cheng; Yang, Chia-Ron
CDK8
发表日期：2025
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An ensemble machine learning model generates a focused screening library for the identification of CDK8 inhibitors

集成机器学习模型生成一个针对性筛选库，用于识别 CDK8 抑制剂。

期刊:Protein Science
影响因子:5.2
doi:10.1002/pro.5007
Lin, Tony Eight; Yen, Dyan; HuangFu, Wei-Chun; Wu, Yi-Wen; Hsu, Jui-Yi; Yen, Shih-Chung; Sung, Tzu-Ying; Hsieh, Jui-Hua; Pan, Shiow-Lin; Yang, Chia-Ron; Huang, Wei-Jan; Hsu, Kai-Cheng
CDK8
发表日期：2024
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A Causal Regulation Modeling Algorithm for Temporal Events with Application to Escherichia coli's Aerobic to Anaerobic Transition

一种用于时间事件的因果调控建模算法及其在大肠杆菌需氧向厌氧转变中的应用

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms25115654
Chen, Yigang; Mao, Runbo; Xu, Jiatong; Huang, Yixian; Xu, Jingyi; Cui, Shidong; Zhu, Zihao; Ji, Xiang; Huang, Shenghan; Huang, Yanzhe; Huang, Hsi-Yuan; Yen, Shih-Chung; Lin, Yang-Chi-Duang; Huang, Hsien-Da
信号转导
发表日期：2024
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In silico identification and biological evaluation of a selective MAP4K4 inhibitor against pancreatic cancer

利用计算机模拟方法鉴定和生物学评价一种针对胰腺癌的选择性MAP4K4抑制剂

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2023.2166039
Chang, Chao-Di; Chao, Min-Wu; Lee, Hsueh-Yun; Liu, Yi-Ting; Tu, Huang-Ju; Lien, Ssu-Ting; Lin, Tony Eight; Sung, Tzu-Ying; Yen, Shih-Chung; Huang, Sing-Han; Hsu, Kai-Cheng; Pan, Shiow-Lin
MAP4
胰腺癌
肿瘤
肿瘤免疫
发表日期：2023
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Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach

利用基于结构的虚拟筛选方法鉴定TAOK1和MAP4K5双重抑制剂

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2020.1843452
Chao, Min-Wu; Lin, Tony Eight; HuangFu, Wei-Chun; Chang, Chao-Di; Tu, Huang-Ju; Chen, Liang-Chieh; Yen, Shih-Chung; Sung, Tzu-Ying; Huang, Wei-Jan; Yang, Chia-Ron; Pan, Shiow-Lin; Hsu, Kai-Cheng
MAP4
发表日期：2021
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