日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies

mRNA-LNP HIV-1三聚体加强针可诱导产生广谱中和抗体的前体

Zhenfei Xie # ,Ying-Cing Lin # ,Jon M Steichen # ,Gabriel Ozorowski # ,Sven Kratochvil ,Rashmi Ray ,Jonathan L Torres ,Alessia Liguori ,Oleksandr Kalyuzhniy ,Xuesong Wang ,John E Warner ,Stephanie R Weldon ,Gordon A Dale ,Kathrin H Kirsch ,Usha Nair ,Sabyasachi Baboo ,Erik Georgeson ,Yumiko Adachi ,Michael Kubitz ,Abigail M Jackson ,Sara T Richey ,Reid M Volk ,Jeong Hyun Lee ,Jolene K Diedrich ,Thavaleak Prum ,Samantha Falcone ,Sunny Himansu ,Andrea Carfi ,John R Yates 3rd ,James C Paulson ,Devin Sok ,Andrew B Ward ,William R Schief ,Facundo D Batista

Affinity gaps among B cells in germinal centers drive the selection of MPER precursors

生发中心B细胞间的亲和力差异驱动MPER前体细胞的选择

Rashmi Ray # ,Torben Schiffner # ,Xuesong Wang # ,Yu Yan # ,Kimmo Rantalainen ,Chang-Chun David Lee ,Shivang Parikh ,Raphael A Reyes ,Gordon A Dale ,Ying-Cing Lin ,Simone Pecetta ,Sophie Giguere ,Olivia Swanson ,Sven Kratochvil ,Eleonora Melzi ,Ivy Phung ,Lisa Madungwe ,Oleksandr Kalyuzhniy ,John Warner ,Stephanie R Weldon ,Ryan Tingle ,Edward Lamperti ,Kathrin H Kirsch ,Nicole Phelps ,Erik Georgeson ,Yumiko Adachi ,Michael Kubitz ,Usha Nair ,Shane Crotty ,Ian A Wilson ,William R Schief ,Facundo D Batista

Vaccination induces broadly neutralizing antibody precursors to HIV gp41

接种疫苗可诱导产生针对 HIV gp41 的广谱中和抗体前体

Torben Schiffner # ,Ivy Phung # ,Rashmi Ray # ,Adriana Irimia # ,Ming Tian # ,Olivia Swanson ,Jeong Hyun Lee ,Chang-Chun D Lee ,Ester Marina-Zárate ,So Yeon Cho ,Jiachen Huang ,Gabriel Ozorowski ,Patrick D Skog ,Andreia M Serra ,Kimmo Rantalainen ,Joel D Allen ,Sabyasachi Baboo ,Oscar L Rodriguez ,Sunny Himansu ,Jianfu Zhou ,Jonathan Hurtado ,Claudia T Flynn ,Katherine McKenney ,Colin Havenar-Daughton ,Swati Saha ,Kaitlyn Shields ,Steven Schultze ,Melissa L Smith ,Chi-Hui Liang ,Laura Toy ,Simone Pecetta ,Ying-Cing Lin ,Jordan R Willis ,Fabian Sesterhenn ,Daniel W Kulp ,Xiaozhen Hu ,Christopher A Cottrell ,Xiaoya Zhou ,Jennifer Ruiz ,Xuesong Wang ,Usha Nair ,Kathrin H Kirsch ,Hwei-Ling Cheng ,Jillian Davis ,Oleksandr Kalyuzhniy ,Alessia Liguori ,Jolene K Diedrich ,Julia T Ngo ,Vanessa Lewis ,Nicole Phelps ,Ryan D Tingle ,Skye Spencer ,Erik Georgeson ,Yumiko Adachi ,Michael Kubitz ,Saman Eskandarzadeh ,Marc A Elsliger ,Rama R Amara ,Elise Landais ,Bryan Briney ,Dennis R Burton ,Diane G Carnathan ,Guido Silvestri ,Corey T Watson ,John R Yates 3rd ,James C Paulson ,Max Crispin ,Gevorg Grigoryan ,Andrew B Ward ,Devin Sok ,Frederick W Alt ,Ian A Wilson ,Facundo D Batista ,Shane Crotty ,William R Schief

Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses

初次体液免疫应答产生的抗体调节二次免疫应答期间幼稚B细胞的募集

Jeroen M J Tas ,Ja-Hyun Koo ,Ying-Cing Lin ,Zhenfei Xie ,Jon M Steichen ,Abigail M Jackson ,Blake M Hauser ,Xuesong Wang ,Christopher A Cottrell ,Jonathan L Torres ,John E Warner ,Kathrin H Kirsch ,Stephanie R Weldon ,Bettina Groschel ,Bartek Nogal ,Gabriel Ozorowski ,Sandhya Bangaru ,Nicole Phelps ,Yumiko Adachi ,Saman Eskandarzadeh ,Michael Kubitz ,Dennis R Burton ,Daniel Lingwood ,Aaron G Schmidt ,Usha Nair ,Andrew B Ward ,William R Schief ,Facundo D Batista

Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice

膜结合的mRNA免疫原降低了人源化小鼠体内激活HIV Env V2顶端导向的广谱中和B细胞前体的阈值。

Eleonora Melzi ,Jordan R Willis ,Krystal M Ma ,Ying-Cing Lin ,Sven Kratochvil ,Zachary T Berndsen ,Elise A Landais ,Oleksandr Kalyuzhniy ,Usha Nair ,John Warner ,Jon M Steichen ,Anton Kalyuzhniy ,Amber Le ,Simone Pecetta ,Manfredo Perez ,Kathrin Kirsch ,Stephanie R Weldon ,Samantha Falcone ,Sunny Himansu ,Andrea Carfi ,Devin Sok ,Andrew B Ward ,William R Schief ,Facundo D Batista

Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies

在人源化小鼠模型中接种疫苗可诱导产生针对 PfCSP 的高保护性抗疟抗体。

Sven Kratochvil ,Chen-Hsiang Shen ,Ying-Cing Lin ,Kai Xu ,Usha Nair ,Lais Da Silva Pereira ,Prabhanshu Tripathi ,Johan Arnold ,Gwo-Yu Chuang ,Eleonora Melzi ,Arne Schön ,Baoshan Zhang ,Marlon Dillon ,Brian Bonilla ,Barbara J Flynn ,Kathrin H Kirsch ,Neville K Kisalu ,Patience K Kiyuka ,Tracy Liu ,Li Ou ,Marie Pancera ,Reda Rawi ,Mateo Reveiz ,Kareen Seignon ,Lawrence T Wang ,Michael T Waring ,John Warner ,Yongping Yang ,Joseph R Francica ,Azza H Idris ,Robert A Seder ,Peter D Kwong ,Facundo D Batista

Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors

利用多重 CRISPR/Cas9 介导技术对携带天然人类 B 细胞受体的临床前小鼠模型进行基因编辑

Xuesong Wang ,Rashmi Ray ,Sven Kratochvil ,Eleonora Melzi ,Ying-Cing Lin ,Sophie Giguere ,Liling Xu ,John Warner ,Diane Cheon ,Alessia Liguori ,Bettina Groschel ,Nicole Phelps ,Yumiko Adachi ,Ryan Tingle ,Lin Wu ,Shane Crotty ,Kathrin H Kirsch ,Usha Nair ,William R Schief ,Facundo D Batista

Enhanced phosphocholine metabolism is essential for terminal erythropoiesis

增强的磷酸胆碱代谢对于终末红细胞生成至关重要

Nai-Jia Huang, Ying-Cing Lin, Chung-Yueh Lin, Novalia Pishesha, Caroline A Lewis, Elizaveta Freinkman, Colin Farquharson, José Luis Millán, Harvey Lodish

Syk mediates IL-17-induced CCL20 expression by targeting Act1-dependent K63-linked ubiquitination of TRAF6

Syk 通过靶向 Act1 依赖的 K63 连接的 TRAF6 泛素化来介导 IL-17 诱导的 CCL20 表达

Nan-Lin Wu, Duen-Yi Huang, Hsin-Ni Tsou, Ying-Cing Lin, Wan-Wan Lin

Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization

Syk 通过衔接子 ASC 磷酸化和增强寡聚化参与 NLRP3 炎症小体介导的 caspase-1 活化

Ying-Cing Lin, Duen-Yi Huang, Jang-Shiun Wang, Yi-Ling Lin, Shie-Liang Hsieh, Kuo-Chin Huang, Wan-Wan Lin