日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Cytotoxic Sesquiterpenoid Quinones and Quinols, and an 11-Membered Heterocycle, Kauamide, from the Hawaiian Marine Sponge Dactylospongia elegans

来自夏威夷海洋海绵 Dactylospongia elegans 的细胞毒性倍半萜醌类和醌类化合物，以及 11 元杂环化合物 Kauamide

期刊:Marine Drugs
影响因子:5.4
doi:10.3390/md17070423
Neupane, Ram P; Parrish, Stephen M; Neupane, Jayanti Bhandari; Yoshida, Wesley Y; Yip, M L Richard; Turkson, James; Harper, Mary Kay; Head, John D; Williams, Philip G
细胞生物学
毒理研究
C. elegans
发表日期：2019
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Glucocorticoid Signaling Enhances Expression of Glucose-Sensing Molecules in Immature Pancreatic Beta-Like Cells Derived from Murine Embryonic Stem Cells In Vitro

体外实验表明，糖皮质激素信号传导可增强小鼠胚胎干细胞衍生的未成熟胰岛β样细胞中葡萄糖感应分子的表达。

期刊:
影响因子:
doi:10.1089/scd.2017.0160
Ghazalli, Nadiah; Wu, Xiaoxing; Walker, Stephanie; Trieu, Nancy; Hsin, Li-Yu; Choe, Justin; Chen, Chialin; Hsu, Jasper; LeBon, Jeanne; Kozlowski, Mark T; Rawson, Jeffrey; Tirrell, David A; Yip, M L Richard; Ku, Hsun Teresa
发育与干细胞
信号转导
干细胞
细胞生物学
免疫/内分泌
发表日期：2018
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Bromotyrosine-derived metabolites from an Indonesian marine sponge in the family Aplysinellidae (Order Verongiida)

来自印度尼西亚海绵（属于 Aplysinellidae 科，Verongiida 目）的溴酪氨酸衍生的代谢物

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2015.11.086
Dai, Jingqiu; Parrish, Stephen M; Yoshida, Wesley Y; Yip, M L Richard; Turkson, James; Kelly, Michelle; Williams, Philip
代谢
发表日期：2016
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Baicalein upregulates DDIT4 expression which mediates mTOR inhibition and growth inhibition in cancer cells

黄芩苷上调DDIT4表达，从而介导mTOR抑制和癌细胞生长抑制。

期刊:Cancer Letters
影响因子:10.1
doi:10.1016/j.canlet.2014.12.033
Wang, Yujun; Han, Ernest; Xing, Quanhua; Yan, Jin; Arrington, Amanda; Wang, Charles; Tully, Dylan; Kowolik, Claudia M; Lu, David M; Frankel, Paul H; Zhai, Jing; Wen, Wei; Horne, David; Yip, M L Richard; Yim, John H
肿瘤
mTOR
DDIT4
肿瘤免疫
细胞生物学
发表日期：2015
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Bortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of AKT and NF-ĸB signaling, and synergizes with an ERK inhibitor

硼替佐米可诱导人髓母细胞瘤细胞凋亡并抑制其生长，这与AKT和NF-κB信号通路的抑制有关，并且与ERK抑制剂具有协同作用。

期刊:Cancer Biology & Therapy
影响因子:4.6
doi:10.4161/cbt.19239
Yang, Fan; Jove, Veronica; Chang, Shirley; Hedvat, Michael; Liu, Lucy; Buettner, Ralf; Tian, Yan; Scuto, Anna; Wen, Wei; Yip, M L Richard; Van Meter, Timothy; Yen, Yun; Jove, Richard
凋亡
表观遗传
信号转导
MAPK/ERK
细胞生物学
AKT
发表日期：2012
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Identification of anti-malarial compounds as novel antagonists to chemokine receptor CXCR4 in pancreatic cancer cells.

鉴定抗疟化合物为胰腺癌细胞中趋化因子受体 CXCR4 的新型拮抗剂

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0031004
Kim Joseph, Yip M L Richard, Shen Xiaoming, Li Hubert, Hsin Li-Yu Charlie, Labarge Samuel, Heinrich Eileen L, Lee Wendy, Lu Jianming, Vaidehi Nagarajan
细胞生物学
胰腺癌
发表日期：2012
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Identification of a natural compound by cell-based screening that enhances interferon regulatory factor-1 activity and causes tumor suppression.

通过基于细胞的筛选鉴定出一种天然化合物，该化合物可增强干扰素调节因子-1的活性并抑制肿瘤生长

期刊:Molecular Cancer Therapeutics
影响因子:5.5
doi:10.1158/1535-7163.MCT-11-0304
Gao Jinbo, Wang Yujun, Xing Quanhua, Yan Jin, Senthil Maheswari, Akmal Yasir, Kowolik Claudia M, Kang Julia, Lu David M, Zhao Ming, Lin Zhixiu, Cheng Christopher H K, Yip M L Richard, Yim John H
肿瘤
发表日期：2011
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Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking

利用高通量计算机模拟对接技术鉴定MDM2-p53蛋白-蛋白相互作用的破坏因子

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2009.04.124
Lawrence, Harshani R; Li, Zhenyu; Yip, M L Richard; Sung, Shen-Shu; Lawrence, Nicholas J; McLaughlin, Mark L; McManus, Gregory J; Zaworotko, Michael J; Sebti, Saïd M; Chen, Jiandong; Guida, Wayne C
MDM2
发表日期：2009
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