日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Modification of the VP1u region boosts transduction of adeno-associated virus vectors for ocular gene therapy.

VP1u 区域的修饰可增强腺相关病毒载体在眼部基因治疗中的转导。

Cui Mengtian, Cheng Shun-Yun, Liang Jialing, McGowan Jackson, Xu Meiyu, Xu Guangchao, Luo Li, Wu Joae, Harman Christine D, Jacobson Amanda L, Kapeller Lydia E, Mayes Melaney A, Namkung Suk, Sharma Tapan, Leland Thomas B, Zhang Fang, Yip Mitchell, Rossmiller Brian, Xue Thomas, Chen Xiupeng, Boonying Wassamon, Lotun Anoushka, Wang Dan, Su Qin, Xie Jun, Wei Yuquan, Rothstein Ann M, Gregory-Ksander Meredith S, Komaromy Andras, Tian Bo, Lin Haijiang, Punzo Claudio, Tai Phillip W L, Gao Guangping

Orthogonal characterization of rAAV reveals vector attributes that drive ITR repair, self-complementary genome formation, and transgene expression.

rAAV 的正交表征揭示了驱动 ITR 修复、自我互补基因组形成和转基因表达的载体属性。

Llinares Carla, Namkung Suk, Yip Mitchell, Vales África, Olagüe Cristina, Mauleón Itsaso, Isola Sergio, Moeini Pedram, González-Aseguinolaza Gloria, Tai Phillip W L, Unzu Carmen

A deep learning model trained on expressed transcripts across different tissue types reveals cell-type codon-optimization preferences.

利用不同组织类型中表达的转录本训练的深度学习模型揭示了细胞类型密码子优化偏好

Ravi Sandhiya, Sharma Tapan, Yip Mitchell, Yang Huiya, Xie Jun, Gao Guangping, Tai Phillip W L

Querying Recombination Junctions of Replication-Competent Adeno-Associated Viruses in Gene Therapy Vector Preparations with Single Molecule, Real-Time Sequencing

利用单分子实时测序技术查询基因治疗载体制备物中具有复制能力的腺相关病毒的重组连接点

Yip, Mitchell; Chen, Jing; Zhi, Yan; Tran, Ngoc Tam; Namkung, Suk; Pastor, Eric; Gao, Guangping; Tai, Phillip W L