Pathogenic variants of TUBB8 cause oocyte spindle defects by disrupting with EB1/CAKP5 interactions and potential treatment targeting microtubule acetylation through HDAC6 inhibition
TUBB8 的致病变异会破坏 EB1/CAKP5 相互作用,从而导致卵母细胞纺锤体缺陷,而通过抑制 HDAC6 可实现针对微管乙酰化的潜在治疗
期刊:Clinical and Translational Medicine
影响因子:7.9
doi:10.1002/ctm2.70193
Hui Luo, Jianhua Chen, Cao Li, Tian Wu, Siyue Yin, Guangping Yang, Yipin Wang, Zhihan Guo, Saifei Hu, Yanni He, Yingnan Wang, Yao Chen, Youqiang Su, Congxiu Miao, Yun Qian, Ruizhi Feng
免疫
细胞生物学
其它细胞
Most
Mouse
Pericentrin