日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi.

丁内酯 A 通过抑制抗药真菌中的翻转酶来增强卡泊芬净的疗效。

Chen Xuefei, Duan H Diessel, Hoy Michael J, Koteva Kalinka, Spitzer Michaela, Guitor Allison K, Puumala Emily, Fiebig Aline A, Hu Guanggan, Yiu Bonnie, Chou Sommer, Bian Zhuyun, Choi Yeseul, Guo Amelia Bing Ya, Wang Wenliang, Sun Sheng, Robbins Nicole, Averette Anna Floyd, Cook Michael A, Truant Ray, MacNeil Lesley T, Brown Eric D, Kronstad James W, Coombes Brian K, Cowen Leah E, Heitman Joseph, Li Huilin, Wright Gerard D

Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans

以Yck2为靶点的小分子结构导向优化作为对抗白色念珠菌的策略

Puumala, Emily; Nandakumar, Meganathan; Yiu, Bonnie; Stogios, Peter J; Strickland, Benjamin G; Zarnowski, Robert; Wang, Xiaoyu; Williams, Noelle S; Savchenko, Alexei; Andes, David R; Robbins, Nicole; Whitesell, Luke; Willson, Timothy M; Cowen, Leah E

Sterol-C4-methyl-oxidase Erg251 governs Candida albicans hypoxic growth, commensalism and virulence.

甾醇-C4-甲基氧化酶 Erg251 控制白色念珠菌的缺氧生长、共生和毒力。

Liu Zhongle, Yiu Bonnie, Basso Pauline, Chen Xuefei, Patel Disha, Davie Taylor, Hossain Saif, Fu Ci, Archambault Linda S, Duncan Dustin, Wright Gerard D, Noble Suzanne M, Robbins Nicole, Cowen Leah E

Expansion of the functional genomics GRACE library reveals genes relevant for temperature-dependent fitness in Candida albicans

功能基因组学GRACE文库的扩展揭示了与白色念珠菌温度依赖性适应性相关的基因

Fu, Ci; Xiong, Emily H; Kupczok, Livia; Archambault, Linda S; Wang, Timothy R W; Holleran, Caitlin; Carruthers-Lay, Duncan; Zhuang, Ting Xuan; Marcoccia, Sofia; Zhang, Haoyang; Chen, Kevin; Anderson, Daniel; Yiu, Bonnie; Liu, Zhongle; Herzel, Lydia; Robbins, Nicole; Cowen, Leah E

Chemoproteomic Profiling of C. albicans for Characterization of Antifungal Kinase Inhibitors.

念珠菌化学蛋白质组学分析用于鉴定抗真菌激酶抑制剂

Shirley David J, Nandakumar Meganathan, Cabrera Aurora, Yiu Bonnie, Puumala Emily, Liu Zhongle, Robbins Nicole, Whitesell Luke, Smith Jeffrey L, Lyons Scott, Mordant Angie L, Herring Laura E, Graves Lee M, Couñago Rafael M, Drewry David H, Cowen Leah E, Willson Timothy M

Characterizing antimicrobial activity of environmental Streptomyces spp. and oral bacterial and fungal isolates from Canis familiaris and Felis catus

对环境链霉菌属以及从家犬和猫口腔中分离的细菌和真菌进行抗菌活性表征

Cowen, Audrey; Yiu, Bonnie; Fallah, Sara; Meyer, Kirsten J; Puumala, Emily; Lee, Yunjin; Zubyk, Haley L; Robbins, Nicole; Nodwell, Justin R; MacAlpine, Jessie; Cowen, Leah E

Structure-guided optimization of small molecules targeting the yeast casein kinase, Yck2, as a therapeutic strategy to combat Candida albicans

以酵母酪蛋白激酶Yck2为靶点的小分子结构导向优化,作为对抗白色念珠菌的治疗策略

Cowen, Leah; Puumala, Emily; Nandakumar, Meganathan; Yiu, Bonnie; Stogios, Peter; Strickland, Benjamin; Zarnowski, Robert; Wang, Xiaoyu; Williams, Noelle; Savchenko, Alexei; Andes, David; Robbins, Nicole; Whitesell, Luke; Willson, Timothy

Chemoproteomic Profiling of C. albicans for Characterization of Anti-fungal Kinase Inhibitors

利用化学蛋白质组学分析白色念珠菌,以鉴定抗真菌激酶抑制剂

Shirley, David J; Nandakumar, Meganathan; Cabrera, Aurora; Yiu, Bonnie; Puumala, Emily; Liu, Zhongle; Robbins, Nicole; Whitesell, Luke; Smith, Jeffrey L; Lyons, Scott P; Mordant, Angie L; Herring, Laura E; Graves, Lee M; Couñago, Rafael M; Drewry, David H; Cowen, Leah E; Willson, Timothy M

Butyrolactol A potentiates caspofungin efficacy against resistant fungi via phospholipid flippase inhibition

丁内酯A通过抑制磷脂翻转酶增强卡泊芬净对耐药真菌的疗效

Chen, Xuefei; Diessel Duan, H; Hoy, Michael J; Koteva, Kalinka; Spitzer, Michaela; Guitor, Allison K; Puumala, Emily; Fiebig, Aline A; Hu, Guanggan; Yiu, Bonnie; Chou, Sommer; Bian, Zhuyun; Choi, Yeseul; Guo, Amelia Bing Ya; Wang, Wenliang; Sun, Sheng; Robbins, Nicole; Averette, Anna Floyd; Cook, Michael A; Truant, Ray; MacNeil, Lesley T; Brown, Eric D; Kronstad, James W; Coombes, Brian K; Cowen, Leah E; Heitman, Joseph; Li, Huilin; Wright, Gerard D

Structure-activity Relationship for Diarylpyrazoles as Inhibitors of the Fungal Kinase Yck2.

二芳基吡唑类化合物作为真菌激酶Yck2抑制剂的构效关系

Shirley David J, Yiu Bonnie, Mancera-Ortiz Ikeer, Stogios Peter J, Liu Zhongle, Robbins Nicole, Whitesell Luke, Cowen Leah E, Drewry David H, Willson Timothy M