Inhibiting KRAS with CD47 and immune checkpoint overcomes intrinsic resistance to combined KRAS and immune checkpoint inhibitor therapy
利用 CD47 和免疫检查点抑制剂抑制 KRAS 可克服对 KRAS 和免疫检查点抑制剂联合疗法的内在耐药性。
期刊:Cell Reports Medicine
影响因子:11.7
doi:10.1016/j.xcrm.2025.102317
Kentaro Hirade,Noritaka Tanaka,Taisuke Kajino,Yuta Adachi,Ryo Kimura,Hitomi Kasuya,Satoru Kisoda,Tze King Tan,Sho Hayakawa,Takahiko Sato,Shogo Yanase,Yoko Kitaura,Takamasa Yamamoto,Yuki Nishioka,Osamu Muto,Daisuke Muraoka,Teruaki Fujishita,Natsumi Kasuga,Kageaki Watanabe,Yoshihiko Sakata,Masahiro Aoki,Hirokazu Matsushita,Takaomi Sanda,Shinsuke Iida,Kohsuke Tsuchiya,Rui Yamaguchi,Hiromichi Ebi
免疫/内分泌
CD4
CD47
RAS
Checkpoint
