日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Engineered dityrosine-bonding of the RSV prefusion F protein imparts stability and potency advantages

RSV 融合前 F 蛋白的工程化二酪氨酸键合赋予了稳定性和效力优势

Sonal V Gidwani, Devarshi Brahmbhatt, Aaron Zomback, Mamie Bassie, Jennifer Martinez, Jian Zhuang, John Schulze, Jason S McLellan, Roberto Mariani, Peter Alff, Daniela Frasca, Bonnie B Blomberg, Christopher P Marshall, Mark A Yondola

Lung ILC2s are activated in BALB/c mice born to immunized mothers despite complete protection against respiratory syncytial virus

尽管免疫母鼠所产的BALB/c小鼠对呼吸道合胞病毒具有完全保护作用,但其肺部ILC2细胞仍被激活。

Kosanovich, Jessica L; Eichinger, Katherine M; Lipp, Madeline A; Gidwani, Sonal V; Brahmbhatt, Devarshi; Yondola, Mark A; Chi, David H; Perkins, Timothy N; Empey, Kerry M

Prior respiratory syncytial virus infection reduces vaccine-mediated Th2-skewed immunity, but retains enhanced RSV F-specific CD8 T cell responses elicited by a Th1-skewing vaccine formulation

既往呼吸道合胞病毒感染会降低疫苗介导的Th2型免疫反应,但仍能维持由Th1型疫苗制剂诱导的增强的RSV F蛋白特异性CD8 T细胞反应。

Eichinger, Katherine M; Kosanovich, Jessica L; Perkins, Timothy N; Oury, Tim D; Petrovsky, Nikolai; Marshall, Christopher P; Yondola, Mark A; Empey, Kerry M

Prefusion RSV F Immunization Elicits Th2-Mediated Lung Pathology in Mice When Formulated With a Th2 (but Not a Th1/Th2-Balanced) Adjuvant Despite Complete Viral Protection

尽管病毒完全保护,但当使用 Th2 佐剂(而非 Th1/Th2 平衡佐剂)配制融合前 RSV F 免疫时,小鼠仍会诱发 Th2 介导的肺部病理。

Eichinger, Katherine M; Kosanovich, Jessica L; Gidwani, Sonal V; Zomback, Aaron; Lipp, Madeline A; Perkins, Timothy N; Oury, Tim D; Petrovsky, Nikolai; Marshall, Christopher P; Yondola, Mark A; Empey, Kerry M

Maternal immunization with adjuvanted RSV prefusion F protein effectively protects offspring from RSV challenge and alters innate and T cell immunity

母体接种佐剂型呼吸道合胞病毒(RSV)融合前F蛋白可有效保护后代免受RSV感染,并改变先天免疫和T细胞免疫。

Eichinger, Katherine M; Kosanovich, Jessica L; Lipp, Madeline A; Perkins, Timothy N; Petrovsky, Nikolai; Marshall, Christopher; Yondola, Mark A; Empey, Kerry M

Formulation of the prefusion RSV F protein with a Th1/Th2-balanced adjuvant provides complete protection without Th2-skewed immunity in RSV-experienced young mice

将RSV融合前F蛋白与Th1/Th2平衡佐剂配制,可在RSV感染过的幼鼠中提供完全保护,且不会引起Th2型免疫反应。

Kosanovich, Jessica L; Eichinger, Katherine M; Lipp, Madeline A; Yondola, Mark A; Perkins, Timothy N; Empey, Kerry M

Direct administration in the respiratory tract improves efficacy of broadly neutralizing anti-influenza virus monoclonal antibodies

直接在呼吸道给药可提高广谱中和抗流感病毒单克隆抗体的疗效

Leyva-Grado, Victor H; Tan, Gene S; Leon, Paul E; Yondola, Mark; Palese, Peter

Biophysical and functional analyses suggest that adenovirus E4-ORF3 protein requires higher-order multimerization to function against promyelocytic leukemia protein nuclear bodies

生物物理和功能分析表明,腺病毒E4-ORF3蛋白需要高级多聚化才能发挥对抗早幼粒细胞白血病蛋白核体的功能。

Patsalo, Vadim; Yondola, Mark A; Luan, Bowu; Shoshani, Ilana; Kisker, Caroline; Green, David F; Raleigh, Daniel P; Hearing, Patrick