日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice

钙黏蛋白11促进免疫抑制和细胞外基质沉积,从而支持小鼠胰腺肿瘤的生长和对吉西他滨的耐药性

Peran, Ivana; Dakshanamurthy, Sivanesan; McCoy, Matthew D; Mavropoulos, Anastasia; Allo, Bedilu; Sebastian, Aimy; Hum, Nicholas R; Sprague, Sara C; Martin, Kelly A; Pishvaian, Michael J; Vietsch, Eveline E; Wellstein, Anton; Atkins, Michael B; Weiner, Louis M; Quong, Andrew A; Loots, Gabriela G; Yoo, Stephen S; Assefnia, Shahin; Byers, Stephen W

A high content clonogenic survival drug screen identifies mek inhibitors as potent radiation sensitizers for KRAS mutant non-small-cell lung cancer.

高含量克隆形成存活药物筛选发现,MEK 抑制剂是 KRAS 突变型非小细胞肺癌的有效放射增敏剂

Lin Steven H, Zhang Jing, Giri Uma, Stephan Clifford, Sobieski Mary, Zhong Ling, Mason Kathy A, Molkentine Jessica, Thames Howard D, Yoo Stephen S, Heymach John V

Mitigating the risk of radiation-induced cancers: limitations and paradigms in drug development

降低辐射诱发癌症风险:药物研发的局限性和范式

Yoo, Stephen S; Jorgensen, Timothy J; Kennedy, Ann R; Boice, John D Jr; Shapiro, Alla; Hu, Tom C-C; Moyer, Brian R; Grace, Marcy B; Kelloff, Gary J; Fenech, Michael; Prasanna, Pataje G S; Coleman, C Norman

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner

小分子GMX1778通过抑制烟酰胺磷酸核糖转移酶(NAMPT)活性,以p53和烟酸磷酸核糖转移酶1(NAPRT1)依赖的方式调节活性氧(ROS)介导的细胞毒性。

Cerna, David; Li, Hongyun; Flaherty, Siobhan; Takebe, Naoko; Coleman, C Norman; Yoo, Stephen S