日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation.

脑集合体中的人类小胶质细胞表现出区域特异性多样性,并对携带 SCN2A 突变的过度兴奋神经元做出反应。

Wu Jiaxiang, Chen Xiaoling, Zhang Jingliang, Wettschurack Kyle, Robinson Morgan, Li Weihao, Zhao Yuanrui, Yoo Ye-Eun, Deming Brody A, Shu Yue, Abeyaratna Akila D, Que Zhefu, Du Dongshu, Tegtmeyer Matthew, Yuan Chongli, Skarnes William C, Zhang Zhong-Yin, Rochet Jean-Christophe, Wu Long-Jun, Yang Yang

Single-nucleus transcriptomics reveal disrupted pathways in the prefrontal cortex of Scn2a -deficient mice

单核转录组学揭示了Scn2a缺陷小鼠前额叶皮层中受损的通路

Yoo, Ye-Eun; Mandal, Purba; Tang, Zhengkuan; Zhang, Zaiyang; Zhang, Jingliang; Chen, Xiaoling; Robinson, Morgan; Eaton, Muriel; Deming, Brody; Halurkar, Manasi; Kothandaraman, Harish; Dabin, Luke C; Jiang, Boyu; Gao, Hongyu; Yuan, Chongli; Lanman, Nadia; Liu, Yunlong; Kim, Jungsu; Baloni, Priyanka; Yang, Yang

Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation: Microglial diversity and response in assembloids.

脑集合体中的人类小胶质细胞表现出区域特异性多样性,并对携带 SCN2A 突变的过度兴奋神经元做出反应:集合体中的小胶质细胞多样性和反应

Wu Jiaxiang, Chen Xiaoling, Zhang Jingliang, Wettschurack Kyle, Robinson Morgan, Li Weihao, Zhao Yuanrui, Yoo Ye-Eun, Deming Brody A, Abeyaratna Akila D, Que Zhefu, Du Dongshu, Tegtmeyer Matthew, Yuan Chongli, Skarnes William C, Rochet Jean-Christophe, Wu Long-Jun, Yang Yang

Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated Scn2a-deficiency.

恢复兴奋/抑制平衡可提高神经元信噪比,并挽救自闭症相关 Scn2a 缺陷引起的社交缺陷

Zhang Jingliang, Eaton Muriel, Chen Xiaoling, Zhao Yuanrui, Kant Shivam, Deming Brody A, Harish Kothandaraman, Nguyen Huynhvi P, Shu Yue, Lai Shirong, Wu Jiaxiang, Que Zhefu, Wettschurack Kyle W, Zhang Zaiyang, Xiao Tiange, Halurkar Manasi S, Olivero-Acosta Maria I, Yoo Ye-Eun, Lanman Nadia A, Koss Wendy A, Skarnes William C, Yang Yang

Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids.

与自闭症相关的 SCN2A 缺陷会破坏人类大脑组装体中的皮质纹状体回路

Chen Xiaoling, Zhang Jingliang, Wu Jiaxiang, Robinson Morgan J, Kothandaraman Harish, Yoo Ye-Eun, Dopeso-Reyes Iria M Gonzalez, Buffenoir Thomas D, Halurkar Manasi S, Zhang Zaiyang, Wang Muhan, Creager Erin N, Zhao Yuanrui, Olivero-Acosta Maria I, Wettschurack Kyle W, Que Zhefu, Yuan Chongli, Schaser Allison J, Lanman Nadia A, Rochet Jean-Christophe, Skarnes William C, Kremer Eric J, Yang Yang

Age, brain region, and gene dosage-differential transcriptomic changes in Shank3-mutant mice

年龄、脑区和基因剂量——Shank3突变小鼠的差异性转录组变化

Yoo, Taesun; Yoo, Ye-Eun; Kang, Hyojin; Kim, Eunjoon

Brain region and gene dosage-differential transcriptomic changes in Shank2-mutant mice

Shank2突变小鼠脑区和基因剂量差异转录组变化

Yoo, Ye-Eun; Yoo, Taesun; Kang, Hyojin; Kim, Eunjoon

Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice

兴奋性突触和间隙连接协同作用,改善 Shank2 突变小鼠的 Pv 神经元爆发放电和皮质社会认知

Eunee Lee #, Seungjoon Lee #, Jae Jin Shin #, Woochul Choi #, Changuk Chung, Suho Lee, Jihye Kim, Seungmin Ha, Ryunhee Kim, Taesun Yoo, Ye-Eun Yoo, Jisoo Kim, Young Woo Noh, Issac Rhim, Soo Yeon Lee, Woohyun Kim, Taekyung Lee, Hyogeun Shin, Il-Joo Cho, Karl Deisseroth, Sang Jeong Kim, Joo Min Park, 

Early Chronic Memantine Treatment-Induced Transcriptomic Changes in Wild-Type and Shank2-Mutant Mice.

早期慢性美金刚治疗诱导野生型和 Shank2 突变小鼠的转录组变化

Yoo Ye-Eun, Lee Seungjoon, Kim Woohyun, Kim Hyosang, Chung Changuk, Ha Seungmin, Park Jinsu, Chung Yeonseung, Kang Hyojin, Kim Eunjoon

Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2(-/-) Mice

早期纠正N-甲基-D-天冬氨酸受体功能可改善成年Shank2(-/-)小鼠的自闭症样社交行为

Chung, Changuk; Ha, Seungmin; Kang, Hyojin; Lee, Jiseok; Um, Seung Min; Yan, Haidun; Yoo, Ye-Eun; Yoo, Taesun; Jung, Hwajin; Lee, Dongwon; Lee, Eunee; Lee, Seungjoon; Kim, Jihye; Kim, Ryunhee; Kwon, Yonghan; Kim, Woohyun; Kim, Hyosang; Duffney, Lara; Kim, Doyoun; Mah, Won; Won, Hyejung; Mo, Seojung; Kim, Jin Yong; Lim, Chae-Seok; Kaang, Bong-Kiun; Boeckers, Tobias M; Chung, Yeonseung; Kim, Hyun; Jiang, Yong-Hui; Kim, Eunjoon