Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation
由ERK5 S496磷酸化介导的聚（ADP-核糖）聚合酶激活形成的细胞核-线粒体正反馈环路，可诱发持续的促炎性衰老表型，并在化疗放疗后加速冠状动脉粥样硬化。
期刊:Redox Biology
影响因子:11.9
doi:10.1016/j.redox.2021.102132
Kotla, Sivareddy; Zhang, Aijun; Imanishi, Masaki; Ko, Kyung Ae; Lin, Steven H; Gi, Young Jin; Moczygemba, Margie; Isgandarova, Sevinj; Schadler, Keri L; Chung, Caroline; Milgrom, Sarah A; Banchs, Jose; Yusuf, Syed Wamique; Amaya, Diana N; Guo, Huifang; Thomas, Tamlyn N; Shen, Ying H; Deswal, Anita; Herrmann, Joerg; Kleinerman, Eugenie S; Entman, Mark L; Cooke, John P; Schifitto, Giovanni; Maggirwar, Sanjay B; McBeath, Elena; Gupte, Anisha A; Krishnan, Sunil; Patel, Zarana S; Yoon, Yisang; Burks, Jared K; Fujiwara, Keigi; Brookes, Paul S; Le, Nhat-Tu; Hamilton, Dale J; Abe, Jun-Ichi
信号转导
心血管
MAPK/ERK
线粒体
衰老
磷酸化
细胞生物学
动脉粥样硬化
