日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PSKH1 kinase activity is differentially modulated via allosteric binding of Ca(2+) sensor proteins

PSKH1激酶活性受Ca(2+)传感器蛋白变构结合的差异性调节。

Horne, Christopher R; Dite, Toby A; Young, Samuel N; Mather, Lucy J; Dagley, Laura F; Johnson, Jared L; Yaron-Barir, Tomer M; Huntsman, Emily M; Daly, Leonard A; Byrne, Dominic P; Cadell, Antonia L; Ng, Boaz H; Yousef, Jumana; Multari, Dylan H; Shen, Lianju; McAloon, Luke M; Manning, Gerard; Febbraio, Mark A; Means, Anthony R; Cantley, Lewis C; Tanzer, Maria C; Croucher, David R; Eyers, Claire E; Eyers, Patrick A; Scott, John W; Murphy, James M

Unconventional binding of calmodulin to CHK2 kinase inhibits catalytic activity.

钙调蛋白与 CHK2 激酶的非常规结合抑制了其催化活性。

Horne Christopher R, Wang Tingting, Young Samuel N, Dite Toby A, Nyvall Hunter G, Suresh Sushant, Davies Katherine A, Gonzalez Castro Abner, Vaibhav Vineet, Mather Lucy J, Dagley Laura F, Belousoff Matthew J, Manning Gerard, Means Anthony R, Burke John E, Petersen Janni, Scott John W, Murphy James M

Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix

颗粒病毒PK-1激酶活性依赖于以调控αC螺旋为中心的侧向二聚化模式。

Oliver, Michael R; Horne, Christopher R; Shrestha, Safal; Keown, Jeremy R; Liang, Lung-Yu; Young, Samuel N; Sandow, Jarrod J; Webb, Andrew I; Goldstone, David C; Lucet, Isabelle S; Kannan, Natarajan; Metcalf, Peter; Murphy, James M

SMCHD1's ubiquitin-like domain is required for N-terminal dimerization and chromatin localization

SMCHD1的泛素样结构域是N端二聚化和染色质定位所必需的。

Gurzau, Alexandra D; Horne, Christopher R; Mok, Yee-Foong; Iminitoff, Megan; Willson, Tracy A; Young, Samuel N; Blewitt, Marnie E; Murphy, James M

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses

通过生化和结构分析,深入了解骨髓增生性肿瘤相关JAK2突变体的激活和SOCS3介导的抑制机制

Varghese, Leila N; Ungureanu, Daniela; Liau, Nicholas P D; Young, Samuel N; Laktyushin, Artem; Hammaren, Henrik; Lucet, Isabelle S; Nicola, Nicos A; Silvennoinen, Olli; Babon, Jeffrey J; Murphy, James M

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

一种基于核苷酸结合特性对假激酶进行亚分类的可靠方法

Murphy, James M; Zhang, Qingwei; Young, Samuel N; Reese, Michael L; Bailey, Fiona P; Eyers, Patrick A; Ungureanu, Daniela; Hammaren, Henrik; Silvennoinen, Olli; Varghese, Leila N; Chen, Kelan; Tripaydonis, Anne; Jura, Natalia; Fukuda, Koichi; Qin, Jun; Nimchuk, Zachary; Mudgett, Mary Beth; Elowe, Sabine; Gee, Christine L; Liu, Ling; Daly, Roger J; Manning, Gerard; Babon, Jeffrey J; Lucet, Isabelle S

Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity.

SOCS3 对细胞因子信号的抑制:抑制模式的特征及其特异性的基础

Babon Jeffrey J, Kershaw Nadia J, Murphy James M, Varghese Leila N, Laktyushin Artem, Young Samuel N, Lucet Isabelle S, Norton Raymond S, Nicola Nicos A